The functional significance of amylase polymorphism in Drosophila melanogaster I. Properties of two amylase variants

Genetica ◽  
1978 ◽  
Vol 49 (2-3) ◽  
pp. 173-180 ◽  
Author(s):  
A. J. W. Hoorn ◽  
W. Scharloo
Keyword(s):  
Drosophila Melanogaster ◽  
Functional Significance ◽  
Amylase Polymorphism

Genetic and Developmental Characterization of Dmca1D, a Calcium Channel α1 Subunit Gene in Drosophila melanogaster

Genetics ◽  
1998 ◽  
Vol 148 (3) ◽  
pp. 1159-1169
Author(s):  
Daniel F Eberl ◽  
Dejian Ren ◽  
Guoping Feng ◽  
Lori J Lorenz ◽  
David Van Vactor ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Calcium Channel ◽  
Functional Significance ◽  
Transmembrane Domain ◽  
Vital Role ◽  
Subunit Gene ◽  
Channel Diversity ◽  
Domain I ◽  
Α1 Subunit

Abstract To begin unraveling the functional significance of calcium channel diversity, we identified mutations in Dmca1D, a Drosophila calcium channel α1 subunit cDNA that we recently cloned. These mutations constitute the l(2)35Fa lethal locus, which we rename Dmca1D. A severe allele, Dmca1DX10, truncates the channel after the IV-S4 transmembrane domain. These mutants die as late embryos because they lack vigorous hatching movements. In the weaker allele, Dmca1DAR66, a cysteine in transmembrane domain I-S1 is changed to tyrosine. Dmca1DAR66 embryos hatch but pharate adults have difficulty eclosing. Those that do eclose have difficulty in fluid-filling of the wings. These studies show that this member of the calcium channel α1 subunit gene family plays a nonredundant, vital role in larvae and adults.

scholarly journals Analysis of the Functional Significance of Linkage Group Conservation in Drosophila

Genetics ◽  
1987 ◽  
Vol 117 (2) ◽  
pp. 233-244
Author(s):  
Arthur J Hilliker ◽  
Silvija N Trusis-Coulter
Keyword(s):  
Drosophila Melanogaster ◽  
Linkage Group ◽  
Functional Significance ◽  
Linkage Groups ◽  
Interphase Chromosome ◽  
Chromosome Arrangement ◽  
Functional Interactions ◽  
Linear Continuity ◽  
Per Se ◽  
Fertility Analysis

ABSTRACT Linkage groups, as defined by chromosome arms in Drosophila melanogaster, appear to have remained largely intact within the genus Drosophila and, possibly, within the higher Diptera per se. We hypothesized that linkage group conservation might have a functional basis (possibly related to interphase chromosome arrangement). To test this hypothesis, a series of autosomal 2-3 translocations were synthesized, creating many new linkage groups. A total of 167 2-3 translocations were recovered, cytologically analyzed to determine their polytene chromosome breakpoints, and tested for homozygous viability and fertility. The breakpoints associated with homozygous viable translocations were randomly distributed throughout the genome, indicating that the linear continuity of the linkage groups could be disrupted quite extensively. Inter se complementation crosses between homozygous lethal translocations having similar breakpoints further confirmed this result, documenting that, at least with respect to homozygous viability, the linear integrity of the autosomal linkage groups was not of major functional significance. Fertility analysis of the homozygous translocations also indicated that sterility could not be a single major factor. Having concluded that linkage group conservation is not based on important functional interactions between specific linked chromosomal segments, or due principally to the sterility of new linkages, the problem of linkage group conservation remains unsolved. Several possible selective factors are discussed, principally segregational load and inbreeding depression, which may contribute to the elimination of new linkage rearrangements.

scholarly journals Functional significance of regulatory map and structural Amy variants in Drosophila melanogaster

Heredity ◽  
1987 ◽  
Vol 58 (3) ◽  
pp. 383-389 ◽  
Author(s):  
A J Klarenberg ◽  
K Sikkema ◽  
W Scharloo
Keyword(s):  
Drosophila Melanogaster ◽  
Functional Significance
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