Distribution of polylactosamines and vinculin in macrophages and foreign body giant cells colonizing the cellophane implant surface

1995 ◽  
Vol 6 (2) ◽  
pp. 110-112 ◽  
Author(s):  
K. Smetana ◽  
J. Fischer
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Implant Surface ◽  
Foreign Body Giant Cells

scholarly journals Fibrin Polymer on the Surface of Biomaterial Implants Drives the Foreign Body Reaction

2021 ◽  
Author(s):  
Arnat Balabiyev ◽  
Nataly P. Podolnikova ◽  
Jacquelyn A. Kilbourne ◽  
D. Page Baluch ◽  
David Lowry ◽  
...  
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Giant Cells ◽  
The Body ◽  
Fibrous Capsule ◽  
Host Proteins ◽  
Implant Surface ◽  
Foreign Body Giant Cells ◽  
Biological Substrate

ABSTRACTImplantation of biomaterials and medical devices in the body triggers the foreign body reaction (FBR) which is characterized by macrophage fusion at the implant surface leading to the formation of foreign body giant cells and the development of the fibrous capsule enveloping the implant. While adhesion of macrophages to the surface is an essential step in macrophage fusion and implanted biomaterials are known to rapidly acquire a layer of host proteins, a biological substrate that is responsible for this process in vivo is unknown. Here we show that mice with genetically-imposed fibrinogen deficiency display a dramatic reduction of macrophage fusion on implanted biomaterials and are protected from the formation of fibrin-containing granulation tissue, a precursor of the fibrous capsule. Furthermore, macrophage fusion on biomaterials implanted in FibAEK mice that express a mutated form of fibrinogen incapable of thrombin-mediated polymerization was strongly reduced. Surprisingly, despite the lack of fibrin, the capsule was formed in FibAEK mice, although it had a different composition and distinct mechanical properties than that in wild-type mice. Specifically, while mononuclear α-SMA-expressing macrophages embedded in the capsule of both strains of mice secreted collagen, the amount of collagen and its density in the tissue of FibAEK mice was reduced. These data identify fibrin polymer as a key biological substrate driving the development of the FBR.

Pulmonary hair embolism in a rescued free-ranging Eurasian otter Lutra lutra in Kinmen, Taiwan

2020 ◽  
Vol 142 ◽  
pp. 55-61
Author(s):  
WT Li ◽  
YL Chiang ◽  
TY Chen ◽  
CL Lai
Keyword(s):  
Foreign Body ◽  
Traumatic Injury ◽  
Lung Parenchyma ◽  
Giant Cells ◽  
Hair Shaft ◽  
Lutra Lutra ◽  
Lung Lobe ◽  
Eurasian Otter ◽  
Foreign Body Giant Cells ◽  
Free Ranging

Eurasian otters Lutra lutra are listed as Near Threatened on the IUCN Red List and are imperiled by habitat loss, water pollution, and poaching. Harassment and attacks by stray animals are also recognized threats to the health of wild Eurasian otters. Pulmonary hair embolism is a possible complication in animals with deep traumatic injury, but to date no cases have been reported in wildlife. A free-ranging, adult male Eurasian otter was rescued due to severe emaciation and multiple bite wounds. The otter died 3 d after rescue and was necropsied. Grossly, a 1.5 × 1.5 × 1.5 cm firm nodule was observed in the left cranial lung lobe. Histologically, a fragment of hair shaft surrounded by multinucleated foreign body giant cells was observed in a medium-sized vein, and extensive eosinophilic infiltration was noted in the adjacent vascular wall and lung parenchyma. Based on the gross and histological findings, the pulmonary lesion was consistent with eosinophilic pneumonia and vasculitis induced by hair embolism. The presence of well-formed multinucleated foreign body giant cells and eosinophils may imply a late stage of foreign body reaction, and thus the presumptive source of hair embolism is an animal bite. This is the first report of pulmonary hair embolism associated with animal bite in a rescued free-ranging Eurasian otter.

Comparison of bone wax and chitosan usage on post-sternotomy bone healing

2020 ◽  
pp. 021849232098409
Author(s):  
Ihsanul Amal ◽  
Heroe Soebroto ◽  
Puruhito
Keyword(s):  
Foreign Body ◽  
Bone Healing ◽  
Postoperative Bleeding ◽  
Giant Cells ◽  
Operative Field ◽  
Inflammatory Reactions ◽  
Foreign Body Giant Cells ◽  
New Zealand White Rabbits ◽  
Affect Bone Healing ◽  
Chitosan Powder

Background Sternotomy is a standard approach performed in almost every surgical procedure on the heart and mediastinum. Effective hemostasis of the sternum is required to keep the operative field dry, avoid excessive blood transfusions during surgery, and prevent reoperation due to massive postoperative bleeding, which can further increase morbidity and mortality in patients. Bone wax is a mechanical hemostat commonly used after sternotomy and has been known to affect bone healing, trigger chronic inflammatory reactions, and increase the rate of infection. The application of chitosan, which has intrinsic hemostat ability, as hemostatic material is believed to improve bone healing following sternotomy. This study aimed to compare the effectiveness of bone wax and chitosan on bone healing after sternotomy. Methods Median sternotomies were performed on 2 groups of New Zealand White rabbits. Each group of 16 animals received either bone wax or chitosan powder as hemostatic material. The degree of bone healing, the number of foreign-body giant cells, and the number of osteoblasts were evaluated after 6 weeks. Results Radiographs showed that significantly more animals in the chitosan group had total sternal healing ( p = 0.033). Histopathology revealed that the number of foreign-body giant cells was significantly less ( p = 0.036) and the number of osteoblasts was significantly greater ( p < 0.0001) in the group of animals that received chitosan. Conclusion The use of chitosan as hemostatic material can promote better bone healing compared to bone wax.

Are Langhans giant cells precursors of foreign-body giant cells?

1978 ◽  
Vol 263 (1) ◽  
pp. 13-21 ◽  
Author(s):  
H. J. van der Rhee ◽  
W. Hillebrands ◽  
W. Th. Daems
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

The transformation of langhans giant cells into foreign body giant cells

1979 ◽  
Vol 4 (1) ◽  
pp. 147
Author(s):  
H.J. van der Rhee ◽  
C.P.M. van der Burgh-de Winter ◽  
W.Th. Daems
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells

1991 ◽  
Vol 96 (2) ◽  
pp. 169-176 ◽  
Author(s):  
J. M. W. Quinn ◽  
N. A. Athanasou ◽  
J.O'D McGee
Keyword(s):  
Extracellular Matrix ◽  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

scholarly journals REACTIONS OF NORMAL AND TUBERCULOUS ANIMALS TO TUBERCULO-PROTEIN AND TUBERCULO-PHOSPHATIDE

1938 ◽  
Vol 68 (5) ◽  
pp. 641-658 ◽  
Author(s):  
Kenneth C. Smithburn ◽  
Florence R. Sabin
Keyword(s):  
Foreign Body ◽  
Skin Test ◽  
Guinea Pigs ◽  
Cellular Response ◽  
Giant Cells ◽  
Epithelioid Cells ◽  
Tissue Degeneration ◽  
Foreign Body Giant Cells ◽  
Microscopic Reaction

Prior observations on the cellular reactions to tuberculo-phosphatide are confirmed and compared with reactions induced by this material in tuberculous animals. In the latter the response is accelerated and augmented and simulates the Koch phenomenon. Tuberculo-protein produces no macroscopic reaction in normal animals. The microscopic reaction of neutrophiles and monocytes regresses in less than a week. The same material in tuberculous animals causes a response characterized by more or less hemorrhage and necrosis, tissue degeneration, and infiltration of neutrophiles and monocytes. Late in the reaction there may be a few epithelioid cells and foreign body giant cells. Preparations of tuberculo-phosphatide which contain no tubercle bacilli, or only a few, induce the typical cellular response but do not induce hypersensitiveness to tuberculin. Repeated intradermal skin-test injections of tuberculo-protein MA-100 in normal guinea pigs may be followed by a mild hypersensitiveness to subsequent injections.

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