A monochromosomal hybrid cell assay for evaluating the genotoxicity of environmental chemicals

1988 ◽  
Vol 4 (4) ◽  
pp. 495-506 ◽  
Author(s):  
Shahbeg S. Sandhu ◽  
Rama D. Gudi ◽  
Raghbir S. Athwal
Keyword(s):  
Hybrid Cell ◽  
Environmental Chemicals ◽  
Cell Assay ◽  
Monochromosomal Hybrid

Chromosomal Assignment of HepG2 3′-Directed Partial cDNA Sequences by Southern Blot Hybridization Using Monochromosomal Hybrid Cell Panels

Genomics ◽  
1994 ◽  
Vol 22 (1) ◽  
pp. 127-136 ◽  
Author(s):  
Atsushi Fukushima ◽  
Kousaku Okubo ◽  
Hidehiko Sugino ◽  
Naohiro Hori ◽  
Ryo Matoba ◽  
...  
Keyword(s):  
Southern Blot ◽  
Hybrid Cell ◽  
Blot Hybridization ◽  
Southern Blot Hybridization ◽  
Chromosomal Assignment ◽  
Cdna Sequences ◽  
Partial Cdna ◽  
Monochromosomal Hybrid

PET in patients with clear-cut multiple chemical sensitivity (MCS)

2002 ◽  
Vol 41 (06) ◽  
pp. 233-239 ◽  
Author(s):  
C. Hausteiner ◽  
A. Drzezga ◽  
P. Bartenstein ◽  
M. Schwaiger ◽  
H. Förstl ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Multiple Chemical Sensitivity ◽  
Environmental Chemicals ◽  
Chemical Sensitivity ◽  
Clear Cut ◽  
Positron Emission ◽  
Symptom Complex ◽  
Brain Changes ◽  
Multiple Chemical

SummaryAim: Multiple chemical sensitivity (MCS) is a controversially discussed symptom complex. Patients afflicted by MCS react to very low and generally nontoxic concentrations of environmental chemicals. It has been suggested that MCS leads to neurotoxic damage or neuroimmunological alteration in the brain detectable by positron emission tomography (PET) and single photon emission computer tomography (SPECT). These methods are often applied to MCS patients for diagnosis, although they never proved appropriate. Method: We scanned 12 MCS patients with PET, hypothesizing that it would reveal abnormal findings. Results: Mild glucose hypometabolism was present in one patient. In comparison with normal controls, the patient group showed no significant functional brain changes. Conclusion: This first systematic PET study in MCS patients revealed no hint of neurotoxic or neuroimmuno-logical brain changes of functional significance.

HAZARD: An Expert System for Risk Assessment of Environmental Chemicals

1987 ◽  
Vol 26 (01) ◽  
pp. 13-23 ◽  
Author(s):  
H. W. Gottinger
Keyword(s):  
Expert System ◽  
Structural Information ◽  
Chemical Carcinogenesis ◽  
Structural Features ◽  
Environmental Chemicals ◽  
Chemical Carcinogens ◽  
Carcinogenic Activity ◽  
Current State ◽  
Structure Activity ◽  
Carcinogenic Potential

AbstractThe purpose of this paper is to report on an expert system in design that screens for potential hazards from environmental chemicals on the basis of structure-activity relationships in the study of chemical carcinogenesis, particularly with respect to analyzing the current state of known structural information about chemical carcinogens and predicting the possible carcinogenicity of untested chemicals. The structure-activity tree serves as an index of known chemical structure features associated with carcinogenic activity. The basic units of the tree are the principal recognized classes of chemical carcinogens that are subdivided into subclasses known as nodes according to specific structural features that may reflect differences in carcinogenic potential among chemicals in the class. An analysis of a computerized data base of known carcinogens (knowledge base) is proposed using the structure-activity tree in order to test the validity of the tree as a classification scheme (inference engine).

A cost-effective quasi single-cell assay for deciphering of clonal architecture of leukemic cells

2020 ◽  
Author(s):  
A Komkov ◽  
A Miroshnichenkova ◽  
A Smirnova ◽  
E Komech ◽  
E Atapina ◽  
...  
Keyword(s):  
Single Cell ◽  
Cost Effective ◽  
Leukemic Cells ◽  
Clonal Architecture ◽  
Cell Assay

Development of an Easy and High-Throughput Cell Assay System with a Culture Chip and an Assay Chip

2010 ◽  
Vol 130 (10) ◽  
pp. 471-475 ◽  
Author(s):  
Kanako Sugiura ◽  
Noritada Kaji ◽  
Yukihiro Okamoto ◽  
Manabu Tokeshi ◽  
Yoshinobu Baba
Keyword(s):  
High Throughput ◽  
Assay System ◽  
Cell Assay

The Molecular Recognition Paradigm of Environmental Chemicals with Biomacromolecules

2016 ◽  
Vol 18 (1) ◽  
pp. 41-47
Author(s):  
Wenjing Zhang ◽  
Liumeng Pan ◽  
Haifei Wang ◽  
Xuan Lv ◽  
Keke Ding
Keyword(s):  
Molecular Recognition ◽  
Environmental Chemicals
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