Na channel density in extrajunctional sarcolemma of fast and slow twitch mouse skeletal muscle fibres: functional implications and plasticity after fast motoneuron transplantation on to a slow muscle

1995 ◽  
Vol 16 (4) ◽  
pp. 430-439 ◽  
Author(s):  
Richard L. Milton ◽  
Michael A. Behforouz
2008 ◽  
Vol 586 (2) ◽  
pp. 441-457 ◽  
Author(s):  
Claude Legrand ◽  
Emiliana Giacomello ◽  
Christine Berthier ◽  
Bruno Allard ◽  
Vincenzo Sorrentino ◽  
...  

1994 ◽  
Vol 125 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Fredrik Vult von Steyern ◽  
Rolf Libelius ◽  
Grace Lawoko ◽  
Sven Tågerud

2021 ◽  
Author(s):  
Sue M Ronaldson ◽  
George D Stephenson ◽  
Stewart I Head

The single skinned muscle fibre technique was used to investigate Ca2+- and Sr2+- activation properties of skeletal muscle fibres from elderly women (66-90 years). Muscle biopsies were obtained from the vastus lateralis muscle. Three populations of muscle fibres were identified according to their specific Sr2+- activation properties: slow-twitch (type I) fast-twitch (type II) and hybrid (type I/II) fibres. All three fibre types were sampled from the biopsies of 66 to 72 years old women, but the muscle biopsies of women older than 80 years yielded only slow-twitch (type I) fibres. The proportion of hybrid fibres in the vastus lateralis muscle of women of circa 70 years of age (24%) was several-fold greater than in the same muscle of adults (<10%), suggesting that muscle remodelling occurs around this age. There were no differences between the Ca2+- and Sr2+- activation properties of slow-twitch fibres from the two groups of elderly women, but there were differences compared with muscle fibres from adults with respect to sensitivity to Ca2+, steepness of the activation curves, and characteristics of the fibre-type dependent phenomenon of spontaneous force oscillations (SOMO) occurring at sub-maximal levels of activation. The maximal Ca2+ activated specific force from all the fibres collected from the seven old women use in the present study was significantly lower by 20% than in the same muscle of adults. Taken together these results show there are qualitative and quantitative changes in the activation properties of the contractile apparatus of muscle fibres from the vastus lateralis muscle of women with advancing age, and that these changes need to be considered when explaining observed changes in womens mobility with aging.


2006 ◽  
pp. 33-34
Author(s):  
John Capote ◽  
Pura Bolaños ◽  
Carlo Caputo

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