Antiischemic effects of trimetazidine: 31P-NMR spectroscopy study in the isolated rat heart

1990 ◽  
Vol 4 (S4) ◽  
pp. 812-813 ◽  
Author(s):  
A. Rossi ◽  
N. Lavanchy ◽  
J. Martin
Keyword(s):  
Nmr Spectroscopy ◽  
Rat Heart ◽  
31P Nmr ◽  
Isolated Rat Heart ◽  
31P Nmr Spectroscopy ◽  
Spectroscopy Study ◽  
Isolated Rat

Evaluation by 31P NMR of the effects of acebutolol on the ischaemic isolated rat heart

1986 ◽  
Vol 125 (3) ◽  
pp. 341-351 ◽  
Author(s):  
Nicole Lavanchy ◽  
Jean Martin ◽  
Martine Giacomelli ◽  
André Rossi
Keyword(s):  
Rat Heart ◽  
31P Nmr ◽  
Isolated Rat Heart ◽  
Isolated Rat

scholarly journals A General Protocol for the Synthesis of H-α-Hydroxyphosphinates

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 421-432 ◽  
Author(s):  
Julia Deschamp ◽  
Marc Lecouvey ◽  
Jade Dussart ◽  
Maelle Monteil ◽  
Olivier Gager ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
31P Nmr ◽  
31P Nmr Spectroscopy ◽  
Spectroscopy Study ◽  
Aromatic Substrates ◽  
Silylating Agent ◽  
Synthetic Procedure ◽  
Complementary Study

A general synthetic procedure was developed for H-α-hydroxyphosphinates via Abramov reaction. The present work is a complementary study to those reported till now. This methodology has the advantage that it can be applied to various aliphatic and (hetero)aromatic substrates. The H-α-hydroxyphosphinates were easily purified and obtained in good to excellent yields in shorter times. A 31P NMR spectroscopy study has shown that only 2 equivalents of a silylating agent were required.

Effect of age on phosphorylated compounds and mechanical activity of isolated rat heart: a 31P-NMR study

1993 ◽  
Vol 27 (11) ◽  
pp. 1978-1982 ◽  
Author(s):  
C Finelli ◽  
J Aussedat ◽  
A Ray ◽  
S Lortet ◽  
N Lavanchy ◽  
...  
Keyword(s):  
Rat Heart ◽  
31P Nmr ◽  
Isolated Rat Heart ◽  
Mechanical Activity ◽  
Nmr Study ◽  
Phosphorylated Compounds ◽  
Effect Of Age ◽  
Isolated Rat

Magnesium and reperfusion of ischemic rat heart as assessed by 31P-NMR

1989 ◽  
Vol 256 (1) ◽  
pp. H195-H204 ◽  
Author(s):  
P. C. Borchgrevink ◽  
A. S. Bergan ◽  
O. E. Bakoy ◽  
P. Jynge
Keyword(s):  
Rat Heart ◽  
31P Nmr ◽  
Creatine Phosphate ◽  
Isolated Rat Heart ◽  
31P Nmr Spectroscopy ◽  
Physiological Concentration ◽  
Reperfusion Period ◽  
Ischemic Period ◽  
Rate Of Recovery ◽  
And Function

Isolated rat heart perfusion and high-resolution phosphate-31 nuclear magnetic resonance (31P-NMR) spectroscopy were used to elucidate the effects of Mg during reperfusion of the ischemic myocardium. After an ischemic period of 9 min, the hearts were reperfused with 0, 0.6, or 2.4 mM Mg during the entire 24-min reperfusion period or with 15 mM Mg during the first 12 min before returning to the physiological concentration of 0.6 mM during the last 12 min. Free intracellular Mg calculated by 31P-NMR rose during ischemia and fell gradually during reperfusion. The two groups reperfused with 15 mM Mg exhibited a significantly enhanced rate of recovery of adenosine triphosphate, creatine phosphate, intracellular pH, and coronary flow rate than the three other groups. Myocardial potassium was significantly higher, and inorganic phosphate was significantly lower at the end of the reperfusion period in these groups. The hearts reperfused with 0 mM Mg presented a significantly higher frequency of ventricular fibrillation (VF) than the other groups. It is concluded that reperfusion with high Mg improves the postischemic recovery of metabolism and function in the rat heart, whereas a Mg-free reperfusion solution increases the frequency of VF.

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