scholarly journals The selective bradycardic effects of zatebradine (UL-FS 49) do not adversely affect left ventricular function in conscious pigs with chronic coronary artery occlusion

1992 ◽  
Vol 6 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Leon J. van Woerkens ◽  
Willem J. van der Giessen ◽  
Pieter D. Verdouw
2010 ◽  
Vol 55 (3) ◽  
pp. 255-261
Author(s):  
Fernanda D Olea ◽  
Andrea De Lorenzi ◽  
Claudia Cortés ◽  
Patricia Cabeza Meckert ◽  
Oscar Cendoya ◽  
...  

1990 ◽  
Vol 20 (1) ◽  
pp. 98
Author(s):  
Bong Kwan Seo ◽  
Mun Hong Doh ◽  
Joong Hyeon Cho ◽  
Sun Il Chung ◽  
Hyeon Ok Lim ◽  
...  

1981 ◽  
Vol 59 (3) ◽  
pp. 287-292
Author(s):  
Z. J. Bosnjak ◽  
J. L. Seacard ◽  
E. J. Zuperku ◽  
R. L. Coon ◽  
H. M. Singh ◽  
...  

The changes in left ventricular segmental contractile force induced by brief periods of ischemia (15 – 90 s) and subsequent reperfusions were analyzed in anesthetized dogs. Segmental coronary artery occlusion (left anterior descending or left circumflex) produced a decrease in segmental ventricular function in the occluded area and an increase in contractile force in the myocardial segment away from the occluded area. With reperfusion, a transient overshoot in contractile force above preischemic control levels was observed in the occluded segment. This overshoot was shown not to be dependent on adrenergic mechanisms but appears to indicate changes in calcium permeability.


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