Variations in biochemical parameters of Heterocapsa sp. and Olisthodiscus luteus grown in 12:12 light:dark cycles I. Cell cycle and nucleic acid composition

Hydrobiologia ◽  
1992 ◽  
Vol 238 (1) ◽  
pp. 139-147 ◽  
Author(s):  
E. Berdalet ◽  
M. Latasa ◽  
M. Estrada
Keyword(s):  
Cell Cycle ◽  
Nucleic Acid ◽  
Acid Composition ◽  
Biochemical Parameters ◽  
Olisthodiscus Luteus

scholarly journals The Effect of L-Asparaginase on the Nucleic Acid Metabolism and Cell Cycle of Human Leukemia Cells

Blood ◽  
1972 ◽  
Vol 39 (4) ◽  
pp. 575-580 ◽  
Author(s):  
E. Fred Saunders
Keyword(s):  
Cell Cycle ◽  
Nucleic Acid ◽  
Dna Synthesis ◽  
Rna Synthesis ◽  
Lymphoblastic Leukemia ◽  
Buffy Coat ◽  
Leukemic Cells ◽  
Nucleic Acid Metabolism ◽  
Rapid Decline ◽  
Human Leukemia

Abstract The effect of L-asparaginase on the cell cycle and nucleic acid synthesis of leukemic cells was studied in five children with acute lymphoblastic leukemia. Following an intravenous infusion of the drug, serial marrow samples were obtained for buffy coat volume, mitotic index, and autoradiographic assessment of DNA and RNA synthesis using tritiated thymidine and tritiated uridine, respectively. A rapid decline in buffy coat volume indicated a lytic effect on lymphoblasts. There was a greater kill of proliferative (blasts in the cell cycle) than nonproliferative (G0) leukemic cells. Mitotic indices changed little until 24 hr; in contrast, thymidine labeling indices decreased markedly to less than 50% of control by 6 hr. The changes in labeling indices prior to changes in mitotic indices indicated that L-asparaginase blocked the entrance of cells into the DNA synthesis period of the cell cycle. Cells already in DNA synthesis appeared to continue into mitosis. Uridine labeling indices decreased progressively in all patients. Uridine uptake was inhibited equally in both proliferative and nonproliferative blasts. Therefore, inhibition of RNA synthesis by L-asparaginase was independent of the proliferative activity of the marrow.

scholarly journals EFFECT OF STORAGE ON THE NUCLEIC ACID COMPOSITION OF BAKER'S YEAST*

1974 ◽  
Vol 80 (3) ◽  
pp. 271-277 ◽  
Author(s):  
E. Parkkinen ◽  
E. Oura ◽  
H. Suomalainen
Keyword(s):  
Nucleic Acid ◽  
Acid Composition ◽  
Baker’S Yeast ◽  
Baker's Yeast

Human Desoxypentose Nucleic Acid: Composition of Human Desoxypentose Nucleic Acid

Nature ◽  
1950 ◽  
Vol 165 (4202) ◽  
pp. 756-757 ◽  
Author(s):  
ERWIN CHARGAFF ◽  
STEPHEN ZAMENHOF ◽  
CHARLOTTE GREEN
Keyword(s):  
Nucleic Acid ◽  
Acid Composition

scholarly journals Portable sequencer in the fight against infectious disease

2019 ◽  
Vol 65 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Arthur Elia Mongan ◽  
Josef Sem Berth Tuda ◽  
Lucky Ronald Runtuwene
Keyword(s):  
Infectious Disease ◽  
Polymerase Chain Reaction ◽  
Nucleic Acid ◽  
Disease Management ◽  
Acid Composition ◽  
Molecular Techniques ◽  
Chain Reaction ◽  
Major Threat ◽  
The World ◽  
Polymerase Chain

Abstract Infectious disease is still a major threat in the world today. Five decades ago, it was considered soon to be eradicated, but the adaptation of pathogens to environmental pressure, such as antimicrobials, encouraged the emergence and reemergence of infectious disease. The fight with infectious disease starts with prevention, diagnosis, and treatment. Diagnosis can be upheld by observing the cause of disease under the microscope or detecting the presence of nucleic acid and proteins of the pathogens. The molecular techniques span from classical polymerase chain reaction (PCR) to sequencing the nucleic acid composition. Here, we are reviewing the works have been undertaken to utilize a portable sequencer, MinION, in various aspects of infectious disease management.

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