Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. III. Antiviral activity

Hydrobiologia ◽  
1987 ◽  
Vol 151-152 (1) ◽  
pp. 497-500 ◽  
Author(s):  
Alejandro M. S. Mayer ◽  
Alberto Diaz ◽  
Analia Pesce ◽  
Marcelo Criscuolo ◽  
Jose F. Groisman ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Sodium Alginate ◽  
Macrocystis Pyrifera

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. III. Antiviral activity

1987 ◽  
pp. 497-500
Author(s):  
Alejandro M. S. Mayer ◽  
Alberto Diaz ◽  
Analia Pesce ◽  
Marcelo Criscuolo ◽  
Jose F. Groisman ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Sodium Alginate ◽  
Macrocystis Pyrifera

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. I. Antitumor, cytotoxicity and humoral immune response

Hydrobiologia ◽  
1987 ◽  
Vol 151-152 (1) ◽  
pp. 483-489 ◽  
Author(s):  
Alejandro M. S. Mayer ◽  
Liliana Krotz ◽  
R. Daniel Bonfil ◽  
Oscar D. Bustuobad ◽  
Jose F. Groisman ◽  
...  
Keyword(s):  
Immune Response ◽  
Biological Activity ◽  
Sodium Alginate ◽  
Humoral Immune Response ◽  
Macrocystis Pyrifera ◽  
Humoral Immune

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. II. Genotoxicity

Hydrobiologia ◽  
1987 ◽  
Vol 151-152 (1) ◽  
pp. 491-496 ◽  
Author(s):  
Irene B. Larripa ◽  
Marta Mudry de Pargament ◽  
Mabel Labal de Vinuesa ◽  
Alejandro M. S. Mayer
Keyword(s):  
Biological Activity ◽  
Sodium Alginate ◽  
Macrocystis Pyrifera

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. II. Genotoxicity

1987 ◽  
pp. 491-496
Author(s):  
Irene B. Larripa ◽  
Marta Mudry de Pargament ◽  
Mabel Labal de Vinuesa ◽  
Alejandro M. S. Mayer
Keyword(s):  
Biological Activity ◽  
Sodium Alginate ◽  
Macrocystis Pyrifera

scholarly journals Blastocysts depict sex-specific signalling of IFNT transcription, translation and activity

Reproduction ◽  
2018 ◽  
Author(s):  
Corina Isabel Schanzenbach ◽  
Sandra Milena Bernal-Ulloa ◽  
Vera Anna van der Weijden ◽  
Michael W. Pfaffl ◽  
Mathias Büttner ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Protein Concentration ◽  
Limit Of Detection ◽  
Activity Level ◽  
Enzyme Linked Immunosorbent Assay ◽  
Protein Activity ◽  
Interferon Tau ◽  
Endometrial Stroma ◽  
Gene And Protein Expression

Preimplantation bovine blastocyst supernatants exhibit sex-dependent antiviral activity, due to the ruminant pregnancy recognition signal Interferon tau (IFNT). Differing potencies of IFNT variants have been supposed as cause, although evidence remains scarce. Here, we aimed at quantifying the sex-dependent IFNT production on transcriptional, translational, and biological activity level in bovine blastocysts, to elucidate the origin of differences in antiviral activity between male and female blastocysts. Day 8 bovine blastocysts were co-cultured with endometrial stroma cells for 48 hours. The embryonic IFNT mRNA expression was determined by quantitative reverse transcription followed by polymerase chain reaction (RT-qPCR). Additionally, the IFNT protein concentration was determined using a sensitive in-house developed IFNT-specific Enzyme-linked-immunosorbent Assay (ELISA). The biological activity was assessed by quantifying the response of Interferon stimulated gene (ISG) expression in endometrial stroma cells. While the IFNT specific ELISA displayed a limit of detection of 7.3 pg/mL, the stroma cell culture system showed to react to as little as 0.1 pg/mL IFNT in RT-qPCR analysis. The female blastocysts had a significant, 5.6-fold, 3.6-fold, and 5.2-fold higher IFNT production than male blastocysts as determined by transcript abundance, protein concentration and, protein activity, respectively. Additionally, all parameters correlated positively, and therefore, we conclude that female blastocysts most likely have an increased IFNT gene and protein expression rather than expressing more potent IFNT variants.

Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity

2018 ◽  
Vol 42 (9) ◽  
pp. 7096-7104 ◽  
Author(s):  
Nataša Perin ◽  
Jasna Alić ◽  
Sandra Liekens ◽  
Arthur Van Aerschot ◽  
Peter Vervaeke ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Side Chains

Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.

scholarly journals The analysis of structure-anticancer and antiviral activity relationships for macrocyclic pyridinophanes and their analogues on the basis of 4D QSAR models (simplex representation of molecular structure).

2002 ◽  
Vol 49 (1) ◽  
pp. 157-168 ◽  
Author(s):  
Victor E Kuz'min ◽  
Anatoly G Artemenko ◽  
Victor P Lozitsky ◽  
Eugene N Muratov ◽  
Alla S Fedtchouk ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Biological Activity ◽  
Antiviral Activity ◽  
Direct Synthesis ◽  
Antiviral Agents ◽  
Structural Models ◽  
Fourth Dimension ◽  
Molecular Fragments ◽  
Qsar Models ◽  
Fixed Structure

A new 4D-QSAR approach has been considered. For all investigated molecules the 3D structural models have been created and the set of conformers (fourth dimension) have been used. Each conformer is represented as a system of different simplexes (tetratomic fragments of fixed structure, chirality and symmetry). The investigation of influence of molecular structure of macrocyclic pyridinophanes, their analogues and certain other compounds on anticancer and antiviral (anti-influenza, antiherpes and antiadenovirus) activity has been carried out by means of the 4D-QSAR. Statistic characteristics for QSAR of PLS (partial least squares) models are satisfactory (R = 0.92-0.97; CVR = 0.63-0.83). Molecular fragments increasing and decreasing biological activity were defined. This information may be useful for design, and direct synthesis of novel anticancer and antiviral agents.

Synthesis and biological activity of adamantane derivatives. III. Antiviral activity of l-(4'-aminophenyl)adamantane derivatives

1976 ◽  
Vol 10 (5) ◽  
pp. 602-605
Author(s):  
G. I. Danilenko ◽  
V. I. Votyakov ◽  
O. T. Andreeva ◽  
M. M. Timofeeva ◽  
M. N. Shashikhina ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Adamantane Derivatives

scholarly journals Synthesis and Antiviral Activity of Hydrogenated Ferulic Acid Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Can Cui ◽  
Zhi-Peng Wang ◽  
Xiu-jiang Du ◽  
Li-Zhong Wang ◽  
Shu-Jing Yu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Ferulic Acid ◽  
Acid Amide ◽  
Molecular Structures ◽  
Amide Derivatives ◽  
Protection Activity

A series of hydrogenated ferulic acid amide derivatives4were synthesized. The molecular structures of the synthesized compounds were analyzed byH1NMR and HRMS. The biological activity study showed that some of them displayed excellent protection activity and curative activity against TMV at 500 μg/mL.

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