Mitochondrial tRNA editing

2004 ◽  
pp. 81-96 ◽  
Author(s):  
Jens Schuster ◽  
Mario Mörl
Keyword(s):  
Mitochondrial Trna ◽  
Trna Editing

scholarly journals A single editing event is a prerequisite for efficient processing of potato mitochondrial phenylalanine tRNA.

1996 ◽  
Vol 16 (7) ◽  
pp. 3504-3510 ◽  
Author(s):  
L Marechal-Drouard ◽  
A Cosset ◽  
C Remacle ◽  
D Ramamonjisoa ◽  
A Dietrich
Keyword(s):  
Plant Mitochondria ◽  
Pcr Amplification ◽  
Mitochondrial Trna ◽  
Processing Efficiency ◽  
Editing Event ◽  
Tertiary Structures ◽  
Reverse Transcription Pcr ◽  
Efficient Processing ◽  
Trna Editing

In bean, potato, and Oenothera plants, the C encoded at position 4 (C4) in the mitochondrial tRNA Phe GAA gene is converted into a U in the mature tRNA. This nucleotide change corrects a mismatched C4-A69 base pair which appears when the gene sequence is folded into the cloverleaf structure. C-to-U conversions constitute the most common editing events occurring in plant mitochondrial mRNAs. While most of these conversions introduce changes in the amino acids specified by the mRNA and appear to be essential for the synthesis of functional proteins in plant mitochondria, the putative role of mitochondrial tRNA editing has not yet been defined. Since the edited form of the tRNA has the correct secondary and tertiary structures compared with the nonedited form, the two main processes which might be affected by a nucleotide conversion are aminoacylation and maturation. To test these possibilities, we determined the aminoacylation properties of unedited and edited potato mitochondrial tRNAPhe in vitro transcripts, as well as the processing efficiency of in vitro-synthesized potato mitochondrial tRNAPhe precursors. Reverse transcription-PCR amplification of natural precursors followed by cDNA sequencing was also used to investigate the influence of editing on processing. Our results show that C-to-U conversion at position 4 in the potato mitochondrial tRNA Phe GAA is not required for aminoacylation with phenylalanine but is likely to he essential for efficient processing of this tRNA.

scholarly journals Extensive and Evolutionarily Persistent Mitochondrial tRNA Editing in Velvet Worms (Phylum Onychophora)

2011 ◽  
Vol 28 (10) ◽  
pp. 2873-2881 ◽  
Author(s):  
Romulo Segovia ◽  
Walker Pett ◽  
Steve Trewick ◽  
Dennis V. Lavrov
Keyword(s):  
Mitochondrial Trna ◽  
Velvet Worms ◽  
Trna Editing

The Possible Common Origin of tRNA and 5S rRNA

1983 ◽  
Vol 38 (5-6) ◽  
pp. 501-504 ◽  
Author(s):  
Mária Ujhelyi
Keyword(s):  
Common Ancestor ◽  
Common Origin ◽  
5S Rrna ◽  
Mitochondrial Trna ◽  
Trna Molecule ◽  
The Common

Seryl tRNA (anticodon GCU) from mammalian mito­chondria shows in comparison to other mitochondrial tRNAs additional special features differing from the generalized tRNA model. When arranged in the tradi­tional cloverleaf form, eight bases fall within the TΨC loop, and the entire dihydrouridine loop is lacking. This seryl tRNA molecule is therefore shorter than other tRNAs. It was originally thought to represent a mito­chondrial analogon of 5 S rRNA and its precise classifica­tion is still disputed. The present studies suggest that this mitochondrial tRNA represents a fossil molecule which is related to the common ancestor of the present tRNA and 5 S rRNA molecules.

scholarly journals Heterogenous Point Mutations in the Mitochondrial tRNA Ser(UCN) Precursor Coexisting with the A1555G Mutation in Deaf Students from Mongolia

1999 ◽  
Vol 65 (6) ◽  
pp. 1803-1806 ◽  
Author(s):  
Arti Pandya ◽  
Xia-Juan Xia ◽  
Raadnabazar Erdenetungalag ◽  
Michael Amendola ◽  
Barbara Landa ◽  
...  
Keyword(s):  
Point Mutations ◽  
Mitochondrial Trna ◽  
Deaf Students ◽  
A1555g Mutation

A novel point mutation in the mitochondrial tRNA(Trp) gene produces late-onset encephalomyopathy, plus additional features

2010 ◽  
Vol 297 (1-2) ◽  
pp. 105-108 ◽  
Author(s):  
Edoardo Malfatti ◽  
Elena Cardaioli ◽  
Carla Battisti ◽  
Paola Da Pozzo ◽  
Alessandro Malandrini ◽  
...  
Keyword(s):  
Point Mutation ◽  
Late Onset ◽  
Mitochondrial Trna
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