Checkpoint and Coordinated Cellular Responses to DNA Damage

2006 ◽  
pp. 65-92 ◽  
Author(s):  
Xiaohong H. Yang ◽  
Lee Zou
Keyword(s):  
Dna Damage ◽  
Cellular Responses

scholarly journals The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage

2016 ◽  
Vol 27 (24) ◽  
pp. 3791-3799 ◽  
Author(s):  
Hafida Sellou ◽  
Théo Lebeaupin ◽  
Catherine Chapuis ◽  
Rebecca Smith ◽  
Anna Hegele ◽  
...  
Keyword(s):  
Dna Damage ◽  
Structural Changes ◽  
Cellular Responses ◽  
Dna Lesions ◽  
Fast Kinetics ◽  
Important Player ◽  
Chromatin Relaxation ◽  
Kinetics Of ◽  
Laser Microirradiation

Chromatin relaxation is one of the earliest cellular responses to DNA damage. However, what determines these structural changes, including their ATP requirement, is not well understood. Using live-cell imaging and laser microirradiation to induce DNA lesions, we show that the local chromatin relaxation at DNA damage sites is regulated by PARP1 enzymatic activity. We also report that H1 is mobilized at DNA damage sites, but, since this mobilization is largely independent of poly(ADP-ribosyl)ation, it cannot solely explain the chromatin relaxation. Finally, we demonstrate the involvement of Alc1, a poly(ADP-ribose)- and ATP-dependent remodeler, in the chromatin-relaxation process. Deletion of Alc1 impairs chromatin relaxation after DNA damage, while its overexpression strongly enhances relaxation. Altogether our results identify Alc1 as an important player in the fast kinetics of the NAD+- and ATP-dependent chromatin relaxation upon DNA damage in vivo.

scholarly journals Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells

2009 ◽  
Vol 37 (9) ◽  
pp. e68-e68 ◽  
Author(s):  
Xiangduo Kong ◽  
Samarendra K. Mohanty ◽  
Jared Stephens ◽  
Jason T. Heale ◽  
Veronica Gomez-Godinez ◽  
...  
Keyword(s):  
Dna Damage ◽  
Comparative Analysis ◽  
Mammalian Cells ◽  
Cellular Responses ◽  
Laser Systems

Cellular Responses to DNA Damage and Human Chromosome Instability Syndromes

1998 ◽  
pp. 395-442 ◽  
Author(s):  
KumKum Khanna ◽  
Richard Gatti ◽  
Patrick Concannon ◽  
Corry M. R. Weemaes ◽  
Merl F. Hoekstra ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Chromosome ◽  
Chromosome Instability ◽  
Cellular Responses

scholarly journals Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0170358 ◽  
Author(s):  
Tao Lu ◽  
Ye Zhang ◽  
Yared Kidane ◽  
Alan Feiveson ◽  
Louis Stodieck ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Damage ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Human Fibroblasts ◽  
Cellular Responses ◽  
Profile Changes

scholarly journals Deciphering MET‐dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics

2020 ◽  
Vol 14 (6) ◽  
pp. 1185-1206
Author(s):  
Ariel Bensimon ◽  
Jonas P. Koch ◽  
Paola Francica ◽  
Selina M. Roth ◽  
Rahel Riedo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cellular Responses ◽  
Quantitative Phosphoproteomics

The cellular responses to DNA damage

1995 ◽  
Vol 5 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Antony M. Carr ◽  
Merl F. Hoekstra
Keyword(s):  
Dna Damage ◽  
Cellular Responses
Sign in / Sign up

Export Citation Format

Share Document