Disease Profiling Arrays: Reverse Format cDNA Arrays Complimentary to Microarrays

2003 ◽  
pp. 191-213 ◽  
Author(s):  
B. Zhumabayeva ◽  
A. Chenchik ◽  
P. D. Siebert ◽  
M. Herrler
Keyword(s):  
Cdna Arrays ◽  
Disease Profiling

Custom-Built CDNA Arrays for the Study of Neuronal Differentiation and Disease: The Smart Chip

ChemInform ◽  
2003 ◽  
Vol 34 (25) ◽  
Author(s):  
Lilian W. Chiang ◽  
Dave Ficenec ◽  
Jill M. Grenier
Keyword(s):  
Neuronal Differentiation ◽  
Cdna Arrays

scholarly journals Comparison of the Predictive Accuracy of DNA Array-Based Multigene Classifiers across cDNA Arrays and Affymetrix GeneChips

2005 ◽  
Vol 7 (3) ◽  
pp. 357-367 ◽  
Author(s):  
James Stec ◽  
Jing Wang ◽  
Kevin Coombes ◽  
Mark Ayers ◽  
Sebastian Hoersch ◽  
...  
Keyword(s):  
Predictive Accuracy ◽  
Dna Array ◽  
Cdna Arrays ◽  
Affymetrix Genechips

scholarly journals Gene Expression Profiling on Global cDNA Arrays Gives Hints Concerning Potential Signal Transduction Pathways Involved in Cardiac Fibrosis of Renal Failure

2003 ◽  
Vol 4 (6) ◽  
pp. 571-583 ◽  
Author(s):  
Kerstin Amann ◽  
Heidrun Ridinger ◽  
Christiane Rutenberg ◽  
Eberhard Ritz ◽  
Gerhard Mall ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Failure ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Cardiac Remodelling ◽  
Cardiomyocyte Hypertrophy ◽  
Specific Gene ◽  
Interstitial Tissue ◽  
Sham Operation ◽  
Cdna Arrays

Cardiac remodelling with interstitial fibrosis in renal failure, which so far is only poorly understood on the molecular level, was investigated in the rat model by a global gene expression profiling analysis. Sprague–Dawley rats were subjected to subtotal nephrectomy (SNX) or sham operation (sham) and followed for 2 and 12 weeks, respectively. Heart-specific gene expression profiling, with RZPD Rat Unigene-1 cDNA arrays containing about 27 000 gene and EST sequences revealed substantial changes in gene expression in SNX compared to sham animals. Motor protein genes, growth and differentiation markers, and extracellular matrix genes were upregulated in SNX rats. Obviously, not only genes involved in cardiomyocyte hypertrophy, but also genes involved in the expansion of non-vascular interstitial tissue are activated very early in animals with renal failure. Together with earlier findings in the SNX model, the present data suggest the hypothesis that the local renin–angiotensin system (RAS) may be activated by at least two pathways: (a) via second messengers and Gproteins (short-term signalling); and (b) via motor proteins, actins and integrins (longterm signalling). The study documents that complex hybridization analysis yields reproducible and promising results of patterns of gene activation pointing to signalling pathways involved in cardiac remodelling in renal failure. The complete array data are available via http://www.rzpd.de/cgi-bin/services/exp/viewExpressionData.pl.cgi

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays

2005 ◽  
Vol 4 (3) ◽  
pp. 399-412 ◽  
Author(s):  
Noriyuki Nakatsu ◽  
Yoko Yoshida ◽  
Kanami Yamazaki ◽  
Tomoki Nakamura ◽  
Shingo Dan ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Cdna Arrays

cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches

2005 ◽  
pp. 1597-1610
Author(s):  
RS Gooch ◽  
TJ Worst ◽  
WM Freeman ◽  
KE Vrana
Keyword(s):  
Cdna Arrays

CNS myeloid cell heterogeneity at the single-cell level

Neuroforum ◽  
2019 ◽  
Vol 25 (3) ◽  
pp. 195-204
Author(s):  
Chotima Böttcher ◽  
Roman Sankowski ◽  
Josef Priller ◽  
Marco Prinz
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Myeloid Cell ◽  
Cellular Heterogeneity ◽  
Cell Heterogeneity ◽  
Mass Cytometry ◽  
Dynamic Regulation ◽  
The Central Nervous System ◽  
Disease Profiling ◽  
The Brain

Abstract The cellular composition of the central nervous system (CNS) is highly complex and dynamic. Regulation of this complexity is increasingly recognized to be spatially and temporally dependent during development, homeostasis and disease. Context-dependent cellular heterogeneity was shown for neuroectodermal cells as well as the myeloid compartment of the CNS. The brain myeloid compartment comprises microglia and other CNS-associated macrophages. These are brain-resident cells with critical roles in brain development, maintenance, and immune responses during states of disease. Profiling of CNS myeloid cell heterogeneity has been greatly facilitated in the past years by development of high-throughput technologies for single-cell analysis. This review summarizes current insights into heterogeneity of the CNS myeloid cell population determined by single-cell RNA sequencing and mass cytometry. The results offer invaluable insights into CNS biology and will facilitate the development of therapies for neurodegenerative and neuroinflammatory pathologies.

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