Fungal Immunology

2005 ◽  
Keyword(s):  
Fungal Immunology

scholarly journals Fungal immunology in clinical practice: Magical realism or practical reality?

2019 ◽  
Vol 57 (Supplement_3) ◽  
pp. S294-S306 ◽  
Author(s):  
Christina C Chang ◽  
Stuart M Levitz
Keyword(s):  
Immune Responses ◽  
Magical Realism ◽  
Fungal Infections ◽  
Innate Immune ◽  
Signaling Cascades ◽  
Fungal Cell ◽  
Adaptive Immune ◽  
Immune Defect ◽  
Practical Reality ◽  
Fungal Immunology

AbstractInvasive fungal infections (IFIs) occur predominantly in immunocompromised individuals but can also be seen in previously well persons. The human innate immune system recognizes key components of the fungal cell wall as foreign resulting in a myriad of signaling cascades. This triggers release of antifungal molecules as well as adaptive immune responses, which kill or at least contain the invading fungi. However, these defences may fail in hosts with primary or secondary immunodeficiencies resulting in IFIs. Knowledge of a patient's immune status enables the clinician to predict the fungal infections most likely to occur. Moreover, the occurrence of an opportunistic mycosis in a patient without known immunocompromise usually should prompt a search for an occult immune defect. A rapidly expanding number of primary and secondary immunodeficiencies associated with mycoses has been identified. An investigative approach to determining the nature of these immunodeficiencies is suggested to help guide clinicians encountering patients with IFI. Finally, promising adjunctive immunotherapy measures are currently being investigated in IFI.

scholarly journals Medical mycology and fungal immunology: new research perspectives addressing a major world health challenge

2016 ◽  
Vol 371 (1709) ◽  
pp. 20150462 ◽  
Author(s):  
Neil A. R. Gow ◽  
Mihai G. Netea
Keyword(s):  
Human Health ◽  
Vaccine Development ◽  
Fungal Infections ◽  
Animal Health ◽  
Basic Research ◽  
World Health ◽  
Medical Mycology ◽  
Health Food ◽  
Research Perspectives ◽  
Fungal Immunology

Fungi cause more than a billion skin infections, more than 100 million mucosal infections, 10 million serious allergies and more than a million deaths each year. Global mortality owing to fungal infections is greater than for malaria and breast cancer and is equivalent to that owing to tuberculosis (TB) and HIV. These statistics evidence fungal infections as a major threat to human health and a major burden to healthcare budgets worldwide. Those patients who are at greatest risk of life-threatening fungal infections include those who have weakened immunity or have suffered trauma or other predisposing infections such as HIV. To address these global threats to human health, more research is urgently needed to understand the immunopathology of fungal disease and human disease susceptibility in order to augment the advances being made in fungal diagnostics and drug development. Here, we highlight some recent advances in basic research in medical mycology and fungal immunology that are beginning to inform clinical decisions and options for personalized medicine, vaccine development and adjunct immunotherapies. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.

From bench to bedside - translational approaches in anti-fungal immunology

2020 ◽  
Vol 58 ◽  
pp. 153-159
Author(s):  
Michelle Seif ◽  
Antje Häder ◽  
Jürgen Löffler ◽  
Oliver Kurzai
Keyword(s):  
Fungal Immunology ◽  
Anti Fungal
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