Regulatory Genomics

2005 ◽  
Keyword(s):  
2020 ◽  
Vol 24 ◽  
pp. 153-154
Author(s):  
Ziv Bar-Joseph ◽  
Itamar Simon

2003 ◽  
Vol 31 (1) ◽  
pp. 55-57 ◽  
Author(s):  
C. Dieterich
Keyword(s):  

2012 ◽  
Vol 19 (2) ◽  
pp. 101-101 ◽  
Author(s):  
Andrea Califano ◽  
Manolis Kellis ◽  
Gustavo Stolovitzky

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 121 ◽  
Author(s):  
Enrico Ferrero

The identification of therapeutic targets is a critical step in the research and developement of new drugs, with several drug discovery programmes failing because of a weak linkage between target and disease. Genome-wide association studies and large-scale gene expression experiments are providing insights into the biology of several common and complex diseases, but the complexity of transcriptional regulation mechanisms often limit our understanding of how genetic variation can influence changes in gene expression. Several initiatives in the field of regulatory genomics are aiming to close this gap by systematically identifying and cataloguing regulatory elements such as promoters and enhacers across different tissues and cell types. In this Bioconductor workflow, we will explore how different types of regulatory genomic data can be used for the functional interpretation of disease-associated variants and for the prioritisation of gene lists from gene expression experiments.


2009 ◽  
Vol 10 (1) ◽  
pp. 202 ◽  
Author(s):  
Martin Vingron ◽  
Alvis Brazma ◽  
Richard Coulson ◽  
Jacques van Helden ◽  
Thomas Manke ◽  
...  

2008 ◽  
Vol 149 (1) ◽  
pp. 171-180 ◽  
Author(s):  
Alper Yilmaz ◽  
Milton Y. Nishiyama ◽  
Bernardo Garcia Fuentes ◽  
Glaucia Mendes Souza ◽  
Daniel Janies ◽  
...  
Keyword(s):  

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