Collagen Biosynthesis

Intracellular enzymes of collagen biosynthesis in rat kidney in streptozotocin diabetes

Diabetes ◽

10.2337/diabetes.25.11.1066 ◽

1976 ◽

Vol 25 (11) ◽

pp. 1066-1070 ◽

Cited By ~ 25

Author(s):

J. Risteli ◽

V. A. Koivisto ◽

H. K. Akerblom ◽

K. I. Kivirikko

Keyword(s):

Rat Kidney ◽

Streptozotocin Diabetes ◽

Collagen Biosynthesis ◽

Intracellular Enzymes

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Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis

Pharmaceutical Biology ◽

10.1080/13880209.2020.1861029 ◽

2020 ◽

Vol 59 (1) ◽

pp. 1-10

Author(s):

Mohammad Reza Farahpour ◽

Sara Sheikh ◽

Elham Kafshdooz ◽

Ali Sonboli

Keyword(s):

Essential Oil ◽

Collagen Biosynthesis ◽

Infected Wound ◽

Zataria Multiflora ◽

Wound Model

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Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy

Amino Acids ◽

10.1007/s00726-021-02968-y ◽

2021 ◽

Author(s):

Jerzy Palka ◽

Ilona Oscilowska ◽

Lukasz Szoka

Keyword(s):

Cell Metabolism ◽

Underlying Mechanism ◽

Collagen Biosynthesis ◽

Proline Metabolism ◽

Proline Dehydrogenase ◽

Histone Demethylases ◽

Proline Oxidase ◽

Prolyl Hydroxylases ◽

Transport Chain ◽

And Control

AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C). During this process, electrons are transferred to electron transport chain producing ATP for survival or they directly reduce oxygen, producing reactive oxygen species (ROS) inducing apoptosis/autophagy. However, the mechanism for switching survival/apoptosis mode is unknown. Although PRODH/POX activity and energetic metabolism were suggested as an underlying mechanism for the survival/apoptosis switch, proline availability for this enzyme is also important. Proline availability is regulated by prolidase (proline supporting enzyme), collagen biosynthesis (proline utilizing process) and proline synthesis from glutamine, glutamate, α-ketoglutarate (α-KG) and ornithine. Proline availability is dependent on the rate of glycolysis, TCA and urea cycles, proline metabolism, collagen biosynthesis and its degradation. It is well established that proline synthesis enzymes, P5C synthetase and P5C reductase as well as collagen prolyl hydroxylases are up-regulated in most of cancer types and control rates of collagen biosynthesis. Up-regulation of collagen prolyl hydroxylase and its exhaustion of ascorbate and α-KG may compete with DNA and histone demethylases (that require the same cofactors) to influence metabolic epigenetics. This knowledge led us to hypothesize that up-regulation of prolidase and PRODH/POX with inhibition of collagen biosynthesis may represent potential pharmacotherapeutic approach to induce apoptosis or autophagic death in cancer cells. These aspects of proline metabolism are discussed in the review as an approach to understand complex regulatory mechanisms driving PRODH/POX-dependent apoptosis/survival.

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