Preliminary studies on the effect of dothiepin and its metabolites on serotonin uptake by human blood platelets in vitro

1981 ◽  
pp. 155-160
Author(s):  
Trevor R. Norman ◽  
Henry Cheng ◽  
Graham D. Burrows
Keyword(s):  
Human Blood ◽  
Blood Platelets ◽  
Serotonin Uptake ◽  
Human Blood Platelets

The Active Serotonin Uptake and the Hypotonic Shock Response of Human Blood Platelets

1974 ◽  
Vol 32 (02/03) ◽  
pp. 391-404
Author(s):  
M. R Hardeman ◽  
Carina J. L. Heynens
Keyword(s):  
Human Blood ◽  
Blood Platelets ◽  
External Factors ◽  
Serotonin Uptake ◽  
Hypotonic Shock ◽  
Shock Response ◽  
Platelet Number ◽  
Ph Dependent ◽  
Human Blood Platelets

SummaryThe present paper is part of a study on the evaluation of the active serotonin uptake and the response to hypotonic shock as in vitro viability tests for human blood platelets.The extraction and fluorometric assay of serotonin in plasma and in platelets were further automated by the introduction of a dialyzer in the earlier described system. Furthermore, the influences of some external factors on both tests were investigated.The serotonin uptake as well as the hypotonic shock response were pH dependent and especially the latter was rather sensitive to small pH changes. Changes in the Na+ : K+ ratio were also found to influence both criteria significantly.The serotonin uptake appeared to be linearly dependent on the platelet number while, within a range of 200 X 103 - 450 X 103 platelets per fxl, the slope of the hypotonic shock response was the same.

scholarly journals Survival and recovery of human platelets stored for five days in a non- plasma medium

Blood ◽  
1986 ◽  
Vol 67 (3) ◽  
pp. 672-675 ◽  
Author(s):  
GA Adams ◽  
SD Swenson ◽  
G Rock
Keyword(s):  
Platelet Aggregation ◽  
Human Blood ◽  
Blood Platelets ◽  
Human Platelets ◽  
Plasma Medium ◽  
Release Reaction ◽  
In Vivo Recovery ◽  
Human Blood Platelets

Abstract Human blood platelets were stored for five days as concentrates in 60 mL of: (a) plasma; (b) non-plasma medium with anticoagulant; and (c) non-plasma medium without anticoagulant. All preparations were equally functional when tested for platelet aggregation and release reaction in response to single agonist or synergistic pairs of agonists in vitro. Platelets stored in non-plasma medium with anti-coagulant had lower kallikrein, fibrino(gen)peptide A, lactate, and beta-thromboglobulin than did plasma controls after five days. In vivo recovery and survival of platelets stored in non-plasma medium with anticoagulant were 51.2% +/- 4.3% and 8.7 +/- 0.3 days, respectively, which were not statistically different from plasma controls of 39.2% +/- 4.9% and 7.2 +/- 0.8 days, respectively. It is concluded that platelets can be stored for five days in a non-plasma medium and still have good in vivo recoveries and survivals.

Effects of ethanol and of other factors on ADP-induced aggregation of human blood platelets in vitro

1980 ◽  
Vol 20 (4) ◽  
pp. 405-415 ◽  
Author(s):  
Ronald P. Quintana ◽  
Andrew Lasslo ◽  
Marion Dugdale ◽  
Lisa L. Goodin ◽  
Eric F. Burkhardt
Keyword(s):  
Human Blood ◽  
Blood Platelets ◽  
Induced Aggregation ◽  
Human Blood Platelets

Physostigmine effects on serotonin uptake in human blood platelets

1985 ◽  
Vol 109 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Jeffrey L. Rausch ◽  
D.S. Janowsky ◽  
S.C. Risch ◽  
L.Y. Huey
Keyword(s):  
Human Blood ◽  
Blood Platelets ◽  
Serotonin Uptake ◽  
Human Blood Platelets

Adsorption of Carbon-14 Dextran to Human Blood Platelets and Red Blood Cells, in Vitro

Vox Sanguinis ◽  
1957 ◽  
Vol 2 (2) ◽  
pp. 104-109 ◽  
Author(s):  
S. ROTHMAN ◽  
E. ADELSON ◽  
A. SCHWEBEL ◽  
R. D. LANGDELL
Keyword(s):  
Red Blood Cells ◽  
Human Blood ◽  
Blood Cells ◽  
Blood Platelets ◽  
Carbon 14 ◽  
Human Blood Platelets

Effects of novel aggregation inhibitors on serotonin uptake by human blood platelets

1987 ◽  
Vol 923 (3) ◽  
pp. 443-450 ◽  
Author(s):  
Andrew Lasslo ◽  
Elwood O. Dillingham ◽  
Ramachander Gollamudi ◽  
Glarretter Carter-Burks
Keyword(s):  
Human Blood ◽  
Blood Platelets ◽  
Serotonin Uptake ◽  
Aggregation Inhibitors ◽  
Human Blood Platelets
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