scholarly journals Systematic Review and Meta-analysis of Intelligence Quotient in Early-Treated Individuals with Classical Galactosemia

2017 ◽  
pp. 115-123 ◽  
Author(s):  
Lindsey Welling ◽  
Susan E. Waisbren ◽  
Kevin M. Antshel ◽  
Hugh-Owen Colhoun ◽  
Matthias Gautschi ◽  
...  
Author(s):  
Alferes AR ◽  
◽  
Oliveiros B ◽  
Pereira C ◽  
◽  
...  

There is a deep-rooted correlation between refractory epilepsy in pediatric age and intelligence development. However, little is known about whether surgical procedures used in pediatric epilepsy treatment can affect Intelligence Quotient (IQ) or not. Factors that might influence postoperative IQ are also a matter of study in several articles. To tackle these issues, a systematic review with meta-analysis was conducted with the terms “epilepsy”, “epileptic”, “surgery”, “surgical”, “Wechsler Scale” and “intelligence tests” in PubMed, the Cochrane Library, EMBASE and Clinical Trials.gov. A descriptive data synthesis was carried out to address each of the objectives and then a metaanalysis using a random effects model was conducted. A meta-regression was performed to ascertain possible factors that could influence postoperative IQ. The meta-analysis of the studies included found a mean difference between postoperative and preoperative full-scale IQ values of 1.014 standardized points (p < 0.001). Among all the articles regarding curative surgeries, only three reported an overall significant improvement in IQ after surgery. Regarding palliative procedures, both studies with anterior corpus callosotomy reported a significant improvement in full-scale IQ values two years after surgery. The meta-regression performed did not find any predictors of change in full-scale IQ.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jose Alberto Martínez-Hortelano ◽  
Celia Álvarez-Bueno ◽  
Iván Cavero-Redondo ◽  
Ángel Herráiz-Adillo ◽  
Carlos Berlanga-Macías ◽  
...  

Abstract Background Gestational weight gain has been associated with some adverse perinatal outcomes, but few studies have examined the association between gestational weight gain and offspring’s cognition and their conclusions are inconsistent. Our systematic review and meta-analysis aimed to synthesize the evidence regarding the association between gestational weight gain and offspring’s cognitive skills. Methods In this systematic review and meta-analysis (PROSPERO number, CRD42017073266), we systematically searched MEDLINE, EMBASE, Web of Science and the Cochrane Library for studies examining association between gestational weight gain and offspring’s cognitive skills, without restriction in study design or language. Two reviewers extracted in an independent way the data. The Quality of Reporting of Observational Longitudinal Research scale was used to assess the quality of included studies. Effect size (ES) for adjusted models and their corresponding 95% confidence intervals were calculated for (i) intelligence quotient, (ii) language related skills and (iii) mathematic related skills comparing offspring’s cognitive skills when gestational weight gain was within recommendations (as reference) with those from mothers whose gestational weight gain was above or below the recommendations. Results Thirteen studies were included. There was a positive trend that associated gestational weight gain above recommendations with better offspring’s intelligence quotient, although not statistically significant (ES 0.02, 95% CI -0.00, 0.05; I2 = 0.00%). Conclusions There is a not significant positive association between gestational weight gain above recommendations and intelligence quotient and some studies reported associations between gestational weight gain and offspring’s cognitive skills. Our analyses confirm a wide variability in the results of studies published so far and highlights the need for conducting studies including specific samples of pregnant women by pre-pregnancy body mass index and trimester of pregnancy.


2021 ◽  
Vol 51 (2) ◽  
pp. 194-200
Author(s):  
Emmet Power ◽  
Sophie Sabherwal ◽  
Colm Healy ◽  
Aisling O’ Neill ◽  
David Cotter ◽  
...  

AbstractPrevious systematic reviews and meta-analyses of cross-sectional data assessing the effect of cannabis on cognitive functioning and intelligence show inconsistent results. We hypothesized that frequent and dependent cannabis use in youth would be associated with Intelligence Quotient (IQ) decline. This study is a systematic review and meta-analysis. We searched Embase, PubMed and PsychInfo from inception to 24 January 2020. We included studies with non-treatment seeking samples and pre- and post-exposure measures of IQ. We requested data from authors if summary data was not available from published work. We preregistered our review with PROSPERO (ID no. CRD42019125624). We found seven cohort studies including 808 cases and 5308 controls. We found a significant effect for the association between frequent or dependent cannabis use in youth and IQ change, Cohen's d = −0.132 (95% CI −0.198 to −0.066) p < 0.001. Statistical heterogeneity between studies was also low at I2 = 0.2%. Study quality was moderate to high. This translates to an average decline of approximately 2 IQ points following exposure to cannabis in youth. Future studies should have longer periods of follow up to assess the magnitude of developmental impact.


2021 ◽  
Author(s):  
Mariana Lima Corrêa ◽  
Pedro San Martin Soares ◽  
Bruna Gonçalves Cordeiro da Silva ◽  
Fernando Wehrmeister ◽  
Bernardo Lessa Horta ◽  
...  

2016 ◽  
Vol 58 (7) ◽  
pp. 672-679 ◽  
Author(s):  
Jamie M Kawadler ◽  
Jonathan D Clayden ◽  
Chris A Clark ◽  
Fenella J Kirkham

2019 ◽  
Vol 10 (1) ◽  
pp. 34
Author(s):  
Akram Sanagoo ◽  
Reza Chaman ◽  
Diana Sarokhani ◽  
Mandana Sarokhani ◽  
Parvin Angha ◽  
...  

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.


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