scholarly journals Management of Life-Threatening Tracheal Stenosis and Tracheomalacia in Patients with Mucopolysaccharidoses

2016 ◽  
pp. 33-39 ◽  
Author(s):  
Christoph Kampmann ◽  
Christiane M. Wiethoff ◽  
Ralf G. Huth ◽  
Gundula Staatz ◽  
Eugen Mengel ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Life Threatening

scholarly journals Computational Evaluation of Surgical Design for Multisegmental Complex Congenital Tracheal Stenosis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Limin Zhu ◽  
Xiaolei Gong ◽  
Jinlong Liu ◽  
Youjin Li ◽  
Yumin Zhong ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Computer Aided Design ◽  
Surgical Correction ◽  
Patient Specific ◽  
Congenital Tracheal Stenosis ◽  
Computational Evaluation ◽  
Life Threatening ◽  
Computational Fluid Dynamics Cfd ◽  
Aerodynamic Parameters ◽  
Aided Design

Multisegmental complex congenital tracheal stenosis (CTS) is an uncommon but potentially life-threatening malformation of the airway. Staged surgery is indicated for the complex pathophysiology of the abnormal trachea. Surgical intervention to fix the stenotic segments may result in different postoperative outcomes. However, only few studies reported the design of surgical correction for multisegmental CTS. We used computer-aided design (CAD) to simulate surgical correction under different schemes to develop a patient-specific tracheal model with two segmental stenoses. Computational fluid dynamics (CFD) was used to compare the outcomes of different designs. Aerodynamic parameters of the trachea were evaluated. An obvious interaction was found between the two segments of stenosis in different surgical designs. The surgical corrective order of stenotic segments greatly affected the aerodynamic parameters and turbulence flows downstream of tracheal stenosis and upstream of the bronchus. Patient-specific studies using CAD and CFD minimize the risk of staged surgical correction and facilitate quantitative evaluation of surgical design for multiple segments of complex CTS.

scholarly journals Life-threatening giant esophageal neurofibroma with severe tracheal stenosis: a case report

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Eisuke Booka ◽  
Mitsuhide Kitano ◽  
Yutaka Nakano ◽  
Koki Mihara ◽  
Shin Nishiya ◽  
...  
Keyword(s):  
Case Report ◽  
Tracheal Stenosis ◽  
Life Threatening

Management of Severe Congenital Tracheal Stenosis

1994 ◽  
Vol 103 (5) ◽  
pp. 351-356 ◽  
Author(s):  
Michael E. Dunham ◽  
Lauren D. Holinger ◽  
Carl L. Backer ◽  
Constantine Mavroudis
Keyword(s):  
Cardiopulmonary Bypass ◽  
Tracheal Stenosis ◽  
Preoperative Diagnosis ◽  
Surgical Repair ◽  
Pericardial Patch ◽  
Congenital Tracheal Stenosis ◽  
Life Threatening ◽  
The Mean

We have managed 23 infants and children with severe tracheal stenosis due to congenital complete tracheal rings producing a long-segment stenosis of the trachea. Nineteen (83%) have survived this life-threatening cause of airway obstruction, 7 of whom also had pulmonary artery slings. Pericardial patch tracheoplasty facilitated by partial cardiopulmonary bypass is currently our preferred technique for surgical repair. Eighteen patients (78%) underwent operative intervention, 3 of whom (17%) have died since surgery. The mean follow-up is 4.5 years. Bronchoscopy is essential for preoperative diagnosis and accurate intraoperative incision of the trachea, and is critical for long-term postoperative airway management. The more distal lesions are associated with increased complications and a higher mortality rate.

scholarly journals Surgical treatment of a female patient with tracheomalacia and expiratory tracheal stenosis

2018 ◽  
Vol 28 (5) ◽  
pp. 626-631
Author(s):  
V. D. Parshin ◽  
S. N. Avdeev ◽  
M. A. Rusakov ◽  
V. A. Titov ◽  
A. V. Parshin
Keyword(s):  
Surgical Treatment ◽  
Tracheal Stenosis ◽  
Inflammatory Diseases ◽  
Tracheobronchial Tree ◽  
Treatment Results ◽  
Chronic Inflammatory Diseases ◽  
Clear Explanation ◽  
Life Threatening ◽  
Membranous Part ◽  
Membranous Wall

Abnormal mobility of the posterior membranous wall of the trachea and large bronchi is seen in many bronchopulmonary chronic inflammatory diseases. Currently, clear explanation of a mechanism of the expiratory tracheal stenosis (ETS) is absent. The advanced ETS is associated with severe ventilation abnormalities including asphyxia and syncope. The latter conditions are considered as indications for surgical treatment. Results of the surgical treatment are controversial and are not fully acceptable. For this reason, the surgical treatment for ETS is not routinely used and any successive case of such treatment is of great interest. Strict indications, such as life-threatening conditions or failure of optimal medical treatment, are required for surgical treatment of patients with tracheomalacia and ETS. Surgical treatment for tracheomalacia and ETS is contraindicated in the case of lobar bronchial lesion impeding stabilization the membranous part of the tracheobronchial tree. 

Relapsing polychondritis—two cases with tracheal stenosis and inner ear involvement

1992 ◽  
Vol 106 (9) ◽  
pp. 841-844 ◽  
Author(s):  
L. J. Clark ◽  
R. A. Wakeel ◽  
A. D. Ormerod
Keyword(s):  
Side Effects ◽  
Rare Disease ◽  
Tracheal Stenosis ◽  
Early Treatment ◽  
Surgical Intervention ◽  
Young Patients ◽  
Relapsing Polychondritis ◽  
The Other ◽  
Life Threatening ◽  
Nose And Throat

AbstractRelapsing polychondritis is a rare disease which often presents firstly to ear, nose and throat (ENT) departments. Its complications, respiratory, cardiovascular, renal and neurological are life-threatening; thus it is important to recognize the disease and its complications early. Treatment for relapsing polychondritis may have serious side-effects which should be taken into account when managing these patients. We report two young patients with relapsing polychondritis and their treatments; both had severe tracheal stenosis responding in one case to pharmacological and in the other to surgical intervention.

scholarly journals Successful Treatment of Life-threatening Tracheal Stenosis Caused by Malignancy with a Self-expanding Hybrid Stent

2018 ◽  
Vol 57 (2) ◽  
pp. 259-263 ◽  
Author(s):  
Daisuke Himeji ◽  
Takeshi Kawaguchi ◽  
Kensuke Setoguchi ◽  
Sakuya Koreishi
Keyword(s):  
Tracheal Stenosis ◽  
Successful Treatment ◽  
Life Threatening

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

1743: Risk Count Assessment: A New Concept for Detection of Life Threatening Prostate Cancer During a Window of Curability

2007 ◽  
Vol 177 (4S) ◽  
pp. 579-580 ◽  
Author(s):  
H. Ballentine Carter ◽  
Anna E. Kettermann ◽  
Luigi Ferrucci ◽  
Patricia Landis ◽  
E. Jeffrey Metter
Keyword(s):  
Prostate Cancer ◽  
Life Threatening
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