Multiscale Modeling in Vascular Disease and Tissue Engineering

2012 ◽  
pp. 241-258 ◽  
Author(s):  
Houman Zahedmanesh ◽  
Caitríona Lally
Keyword(s):  
Tissue Engineering ◽  
Vascular Disease ◽  
Multiscale Modeling

scholarly journals Generating vascular conduits: from tissue engineering to three-dimensional bioprinting

2018 ◽  
Vol 3 (3) ◽  
pp. 203-213 ◽  
Author(s):  
Renee M. Maina ◽  
Maria J. Barahona ◽  
Michele Finotti ◽  
Taras Lysyy ◽  
Peter Geibel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Disease ◽  
De Novo ◽  
Three Dimensional ◽  
Steady Increase ◽  
3D Bioprinting ◽  
Vascular Intervention ◽  
Mammary Arteries ◽  
Artery Disease ◽  
Autologous Grafts

AbstractVascular disease – including coronary artery disease, carotid artery disease, and peripheral vascular disease – is a leading cause of morbidity and mortality worldwide. The standard of care for restoring patency or bypassing occluded vessels involves using autologous grafts, typically the saphenous veins or internal mammary arteries. Yet, many patients who need life- or limb-saving procedures have poor outcomes, and a third of patients who need vascular intervention have multivessel disease and therefore lack appropriate vasculature to harvest autologous grafts from. Given the steady increase in the prevalence of vascular disease, there is great need for grafts with the biological and mechanical properties of native vessels that can be used as vascular conduits. In this review, we present an overview of methods that have been employed to generate suitable vascular conduits, focusing on the advances in tissue engineering methods and current three-dimensional (3D) bioprinting methods. Tissue-engineered vascular grafts have been fabricated using a variety of approaches such as using preexisting scaffolds and acellular organic compounds. We also give an extensive overview of the novel use of 3D bioprinting as means of generating new vascular conduits. Different strategies have been employed in bioprinting, and the use of cell-based inks to create de novo structures offers a promising solution to bridge the gap of paucity of optimal donor grafts. Lastly, we provide a glimpse of our work to create scaffold-free, bioreactor-free, 3D bioprinted vessels from a combination of rat vascular smooth muscle cells and fibroblasts that remain patent and retain the tensile and mechanical strength of native vessels.

MULTISCALE MODELING ON BONE TISSUE ENGINEERING

2008 ◽  
Vol 41 ◽  
pp. S501
Author(s):  
J.A. Sanz-Herrera ◽  
J.M. García-Aznar ◽  
M. Doblaré
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Multiscale Modeling

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Abstract #234 High Prevalence of Systemic Collagen Vascular Disease in Women with T1DM

2018 ◽  
Vol 24 ◽  
pp. 45-46
Author(s):  
Yicheng Bao ◽  
Jing Hughes ◽  
Maamoun Salam ◽  
Janet McGill
Keyword(s):  
Vascular Disease ◽  
Collagen Vascular Disease ◽  
High Prevalence
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