Spinal Cord Mechanical Properties

Author(s):  
Elizabeth C. Clarke
2012 ◽  
Vol 46 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Joanna H.L. Diong ◽  
Robert D. Herbert ◽  
Lisa A. Harvey ◽  
Li Khim Kwah ◽  
Jillian L. Clarke ◽  
...  

2008 ◽  
Vol 89 (11) ◽  
pp. e13-e14
Author(s):  
Ji Woong Park ◽  
Ki-Un Jang ◽  
Hyuck Lee ◽  
Ju Yun Lee ◽  
Yang Gyun Lee ◽  
...  

2008 ◽  
Vol 25 (1) ◽  
pp. 38-51 ◽  
Author(s):  
Jason T. Maikos ◽  
Ragi A.I. Elias ◽  
David I. Shreiber

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2693
Author(s):  
Anna Lis-Bartos ◽  
Dariusz Szarek ◽  
Małgorzata Krok-Borkowicz ◽  
Krzysztof Marycz ◽  
Włodzimierz Jarmundowicz ◽  
...  

Highly porous, elastic, and degradable polyurethane and polyurethane/polylactide (PU/PLDL) sponges, in various shapes and sizes, with open interconnected pores, and porosity up to 90% have been manufactured. They have been intended for gap filling in the injured spinal cord. The porosity of the sponges depended on the content of polylactide, i.e., it decreased with the increase of polylactide content. The rise of polylactide content caused an increase of Young modulus and rigidity as well as a more complex morphology of the polyurethane/polylactide blends. The mechanical properties, in vitro toxicity, and degradation in artificial cerebrospinal fluid were tested. Sponges underwent continuous degradation with varying degradation rates depending on the polymer composition. In vitro cell studies with fibroblast cultures proved the biocompatibility of the polymers. Based on the obtained results, the designed PU/PLDL sponges appeared to be promising candidates for bridging gaps within injured spinal cord in further in vitro and in vivo studies.


Author(s):  
Justin Yu ◽  
Neda Manouchehri ◽  
Shun Yamamoto ◽  
Brian K. Kwon ◽  
Thomas R. Oxland

2014 ◽  
Vol 28 (3) ◽  
pp. 296-299
Author(s):  
Kazuhiko Ichihara ◽  
Itsuo Sakuramoto ◽  
Junji Ohgi ◽  
Tetsumi Fukumoto ◽  
Daigo Nakandakari ◽  
...  

Author(s):  
D. Claire Gloeckner ◽  
Michael B. Chancellor ◽  
Michael S. Sacks

Changes in the mechanical properties of the urinary bladder wall following neurogenic disease or trauma can result in bladder dysfunction. We have recently reported changes in the biaxial mechanical properties of the bladder wall 10 days after spinal cord injury in a rat model [1]. Development of a constitutive model to characterize these changes would facilitate quantitative comparisons and provide the necessary information for organ-level computational modeling. However, before an appropriate constitutive model of the bladder wall can be formulated, its material class must be identified. In the present study, we applied a generalized method for material classification of biaxial mechanical data to our previous data on the urinary bladder wall.


Author(s):  
Harini G. Sundararaghavan ◽  
David I. Shreiber

Biomaterial scaffolds for nerve and spinal cord regeneration must not only promote neurite re-growth but also direct it. Several cell types, including neurons, respond to the mechanical properties of the substrate on which they are grown. We believe that gradients of mechanical properties can be used to direct neurons. To spatially control the mechanical properties, gradients of genipin — a naturally occurring, cell-tolerated crosslinking agent — are created in 3D through a compliant collagen gel using microfluidics. Gradients of mechanical properties are evaluated by measuring genipin-induced fluorescence, which we have previously correlated to mechanical properties. Growth of neurites was evaluated in gels of uniform stiffness and a gradient generated by incubation in 0 to 1 mM genipin for 12hrs to produce approximately an order of magnitude change in the shear modulus. Neurite growth was evaluated 5 days after gradient formation. Neurites demonstrated a directional bias against the gradient of stiffness. These results demonstrate that neurites can respond to subtle gradients of mechanical properties within a 3D scaffold and point to opportunities to manipulate properties for directed nerve and spinal cord regeneration.


2018 ◽  
Vol 7 (4) ◽  
pp. 2236 ◽  
Author(s):  
Ayad M. Takhakh ◽  
Saif M. Abbas

Knee ankle foot orthoses (KAFOs) are used by paraplegia patients with low level spinal cord injury and having well control of the stem muscles. Four layers of carbon fiber with C- orthocryl lamination resin are used for manufacturing the knee ankle foot orthoses in this work. The mechanical properties of most of the components materials were estimated with the aid of fatigue and tensile test machines. Results of the tensile tests showed that the mechanical properties: yield stress, ultimate strength and modulus of elasticity were 92MPa, 105.7MPa and 2GPa respectively. The value of amidst pressure between the patient limb and the manufactured KAFO was measured using (F-socket) Mat scan sensor and these values of pressure were (663kPa) and (316kPa) for the thigh and calf regions respectively. 


Author(s):  
Ross Kleiman ◽  
Michelle Previtera ◽  
Sharan Parikh ◽  
Devendra Verma ◽  
Rene Schloss ◽  
...  

Spinal cord injuries have spurred research interests in finding ways to repair or replace damaged neurons. We are looking to find novel ways to promote proliferation and differentiation of stem cells in order to replace damaged spinal cord neurons. While previous studies have shown that the mechanical properties of the cellular environment influence proliferation and differentiation, these studies have only been performed on polyacrylamide and agarose gels (1, 2). Collagen gels provide the opportunity to promote neuronal precursor cell (NPCs) proliferation and differentiation in a more natural environment by utilizing the mechanical properties of the gel. In this study, we examine the effects of 2D collagen matrices of varying stiffness on proliferation and differentiation of rat, spinal cord NPCs in order to create a more biocompatible tissue-engineered platform.


Sign in / Sign up

Export Citation Format

Share Document