Spinal Cord Mechanical Properties

2010 ◽  
pp. 25-40 ◽  
Author(s):  
Elizabeth C. Clarke
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord

Passive mechanical properties of the gastrocnemius after spinal cord injury

2012 ◽  
Vol 46 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Joanna H.L. Diong ◽  
Robert D. Herbert ◽  
Lisa A. Harvey ◽  
Li Khim Kwah ◽  
Jillian L. Clarke ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury

Course 510: Spinal cord injury: Changes of the Skin Mechanical Properties After Spinal Cord Injury

2008 ◽  
Vol 89 (11) ◽  
pp. e13-e14
Author(s):  
Ji Woong Park ◽  
Ki-Un Jang ◽  
Hyuck Lee ◽  
Ju Yun Lee ◽  
Yang Gyun Lee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury

Mechanical Properties of Dura Mater from the Rat Brain and Spinal Cord

2008 ◽  
Vol 25 (1) ◽  
pp. 38-51 ◽  
Author(s):  
Jason T. Maikos ◽  
Ragi A.I. Elias ◽  
David I. Shreiber
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Rat Brain ◽  
Dura Mater ◽  
Brain And Spinal Cord

scholarly journals Microstructure and Mechanical Properties of PU/PLDL Sponges Intended for Grafting Injured Spinal Cord

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2693
Author(s):  
Anna Lis-Bartos ◽  
Dariusz Szarek ◽  
Małgorzata Krok-Borkowicz ◽  
Krzysztof Marycz ◽  
Włodzimierz Jarmundowicz ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Young Modulus ◽  
In Vivo Studies ◽  
Polymer Composition ◽  
In Vitro Toxicity ◽  
Injured Spinal Cord ◽  
Degradation Rates

Highly porous, elastic, and degradable polyurethane and polyurethane/polylactide (PU/PLDL) sponges, in various shapes and sizes, with open interconnected pores, and porosity up to 90% have been manufactured. They have been intended for gap filling in the injured spinal cord. The porosity of the sponges depended on the content of polylactide, i.e., it decreased with the increase of polylactide content. The rise of polylactide content caused an increase of Young modulus and rigidity as well as a more complex morphology of the polyurethane/polylactide blends. The mechanical properties, in vitro toxicity, and degradation in artificial cerebrospinal fluid were tested. Sponges underwent continuous degradation with varying degradation rates depending on the polymer composition. In vitro cell studies with fibroblast cultures proved the biocompatibility of the polymers. Based on the obtained results, the designed PU/PLDL sponges appeared to be promising candidates for bridging gaps within injured spinal cord in further in vitro and in vivo studies.

Mechanical properties of spinal cord grey matter and white matter in confined compression

2020 ◽  
Vol 112 ◽  
pp. 104044
Author(s):  
Justin Yu ◽  
Neda Manouchehri ◽  
Shun Yamamoto ◽  
Brian K. Kwon ◽  
Thomas R. Oxland
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
White Matter ◽  
Grey Matter ◽  
Confined Compression

scholarly journals Pathophysiology of Cervical Myelopathy Related with Aging Mechanical Properties of the Spinal Cord

2014 ◽  
Vol 28 (3) ◽  
pp. 296-299
Author(s):  
Kazuhiko Ichihara ◽  
Itsuo Sakuramoto ◽  
Junji Ohgi ◽  
Tetsumi Fukumoto ◽  
Daigo Nakandakari ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Cervical Myelopathy

Changes in Material Classification of the Urinary Bladder Wall After Spinal Cord Injury

2002 ◽  
Author(s):  
D. Claire Gloeckner ◽  
Michael B. Chancellor ◽  
Michael S. Sacks
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Urinary Bladder ◽  
Constitutive Model ◽  
Bladder Wall ◽  
Material Classification ◽  
Cord Injury ◽  
Urinary Bladder Wall

Changes in the mechanical properties of the urinary bladder wall following neurogenic disease or trauma can result in bladder dysfunction. We have recently reported changes in the biaxial mechanical properties of the bladder wall 10 days after spinal cord injury in a rat model [1]. Development of a constitutive model to characterize these changes would facilitate quantitative comparisons and provide the necessary information for organ-level computational modeling. However, before an appropriate constitutive model of the bladder wall can be formulated, its material class must be identified. In the present study, we applied a generalized method for material classification of biaxial mechanical data to our previous data on the urinary bladder wall.

Directing Neurite Growth in 3D Collagen Scaffolds With Gradients of Mechanical Properties

2007 ◽  
Author(s):  
Harini G. Sundararaghavan ◽  
David I. Shreiber
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Crosslinking Agent ◽  
Collagen Gel ◽  
Neurite Growth ◽  
Cell Types ◽  
Spinal Cord Regeneration ◽  
3D Scaffold ◽  
Directional Bias ◽  
Order Of Magnitude

Biomaterial scaffolds for nerve and spinal cord regeneration must not only promote neurite re-growth but also direct it. Several cell types, including neurons, respond to the mechanical properties of the substrate on which they are grown. We believe that gradients of mechanical properties can be used to direct neurons. To spatially control the mechanical properties, gradients of genipin — a naturally occurring, cell-tolerated crosslinking agent — are created in 3D through a compliant collagen gel using microfluidics. Gradients of mechanical properties are evaluated by measuring genipin-induced fluorescence, which we have previously correlated to mechanical properties. Growth of neurites was evaluated in gels of uniform stiffness and a gradient generated by incubation in 0 to 1 mM genipin for 12hrs to produce approximately an order of magnitude change in the shear modulus. Neurite growth was evaluated 5 days after gradient formation. Neurites demonstrated a directional bias against the gradient of stiffness. These results demonstrate that neurites can respond to subtle gradients of mechanical properties within a 3D scaffold and point to opportunities to manipulate properties for directed nerve and spinal cord regeneration.

scholarly journals Manufacturing and analysis of carbon fiber knee ankle foot orthosis

2018 ◽  
Vol 7 (4) ◽  
pp. 2236 ◽  
Author(s):  
Ayad M. Takhakh ◽  
Saif M. Abbas
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Carbon Fiber ◽  
Tensile Tests ◽  
Foot Orthoses ◽  
Well Control ◽  
Ankle Foot Orthosis ◽  
Cord Injury ◽  
Ankle Foot Orthoses ◽  
Foot Orthosis

Knee ankle foot orthoses (KAFOs) are used by paraplegia patients with low level spinal cord injury and having well control of the stem muscles. Four layers of carbon fiber with C- orthocryl lamination resin are used for manufacturing the knee ankle foot orthoses in this work. The mechanical properties of most of the components materials were estimated with the aid of fatigue and tensile test machines. Results of the tensile tests showed that the mechanical properties: yield stress, ultimate strength and modulus of elasticity were 92MPa, 105.7MPa and 2GPa respectively. The value of amidst pressure between the patient limb and the manufactured KAFO was measured using (F-socket) Mat scan sensor and these values of pressure were (663kPa) and (316kPa) for the thigh and calf regions respectively. 

The Effects of Extracellular Matrix Proteins and Stiffness on Neuronal Cell Adhesion

2011 ◽  
Author(s):  
Ross Kleiman ◽  
Michelle Previtera ◽  
Sharan Parikh ◽  
Devendra Verma ◽  
Rene Schloss ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Spinal Cord Injuries ◽  
Neuronal Cell ◽  
Collagen Gels ◽  
Collagen Matrices ◽  
Spinal Cord Neurons ◽  
Cellular Environment ◽  
Proliferation And Differentiation ◽  
Neuronal Precursor Cell

Spinal cord injuries have spurred research interests in finding ways to repair or replace damaged neurons. We are looking to find novel ways to promote proliferation and differentiation of stem cells in order to replace damaged spinal cord neurons. While previous studies have shown that the mechanical properties of the cellular environment influence proliferation and differentiation, these studies have only been performed on polyacrylamide and agarose gels (1, 2). Collagen gels provide the opportunity to promote neuronal precursor cell (NPCs) proliferation and differentiation in a more natural environment by utilizing the mechanical properties of the gel. In this study, we examine the effects of 2D collagen matrices of varying stiffness on proliferation and differentiation of rat, spinal cord NPCs in order to create a more biocompatible tissue-engineered platform.

Sign in / Sign up

Export Citation Format

Share Document