Revisiting Old Questions and New Approaches to Investigate the Fungal Cell Wall Construction

2020 ◽  
pp. 331-369
Author(s):  
Michael Blatzer ◽  
Anne Beauvais ◽  
Bernard Henrissat ◽  
Jean-Paul Latgé
Keyword(s):  
Cell Wall ◽  
Fungal Cell Wall ◽  
Fungal Cell ◽  
New Approaches ◽  
Wall Construction

Interactions of proteins with other wall components: a pivotal step in fungal cell wall construction

1995 ◽  
Vol 73 (S1) ◽  
pp. 384-387 ◽  
Author(s):  
R. Sentandreu ◽  
M. Sentandreu ◽  
M. V. Elorza ◽  
M. Iranzo ◽  
S. Mormeneo
Keyword(s):  
Cell Wall ◽  
Protein Interactions ◽  
Cell Walls ◽  
Noncovalent Interactions ◽  
Fungal Cell Wall ◽  
Fungal Cell ◽  
Covalent Bonds ◽  
Viscoelastic Composite ◽  
Wall Construction ◽  
Wall Components

Following synthesis of its individual components, the cell wall of Candida albicans is assembled extracellularly in two steps. First, a viscoelastic composite is formed by noncovalent interactions between mannoproteins and other wall components. Second, the initial network is consolidated by formation of covalent cross-linkages among the wall polymers. In both processes, specific proteins may regulate the final yeast or mycelial morphology. These proteins might carry out part of what could be called a morphogenetic code. Experimental results have shown that some mannoproteins form supramolecular complexes. They are secreted independently, but released together from cell walls by hydrolases. In C. albicans cell walls a transglutaminase activity has been detected that could be responsible for the formation of covalent bonds between structural proteins. Key words: fungal cell wall, construction, morphogenesis, protein interactions, noncovalent linkages, covalent linkages.

Recent Status and Advancements in the Development of Antifungal Agents: Highlights on Plant and Marine Based Antifungals

2019 ◽  
Vol 19 (10) ◽  
pp. 812-830 ◽  
Author(s):  
P. Marie Arockianathan ◽  
Monika Mishra ◽  
Rituraj Niranjan
Keyword(s):  
Cell Wall ◽  
Antifungal Agents ◽  
Fungal Diseases ◽  
Fungal Cell Wall ◽  
Fungal Resistance ◽  
Ergosterol Biosynthesis ◽  
Fungal Cell ◽  
Ergosterol Synthesis ◽  
Glucan Synthesis ◽  
Anti Fungal

The developing resistance in fungi has become a key challenge, which is being faced nowadays with the available antifungal agents in the market. Further search for novel compounds from different sources has been explored to meet this problem. The current review describes and highlights recent advancement in the antifungal drug aspects from plant and marine based sources. The current available antifungal agents act on specific targets on the fungal cell wall, like ergosterol synthesis, chitin biosynthesis, sphingolipid synthesis, glucan synthesis etc. We discuss some of the important anti-fungal agents like azole, polyene and allylamine classes that inhibit the ergosterol biosynthesis. Echinocandins inhibit β-1, 3 glucan synthesis in the fungal cell wall. The antifungals poloxins and nikkomycins inhibit fungal cell wall component chitin. Apart from these classes of drugs, several combinatorial therapies have been carried out to treat diseases due to fungal resistance. Recently, many antifungal agents derived from plant and marine sources showed potent activity. The renewed interest in plant and marine derived compounds for the fungal diseases created a new way to treat these resistant strains which are evident from the numerous literature publications in the recent years. Moreover, the compounds derived from both plant and marine sources showed promising results against fungal diseases. Altogether, this review article discusses the current antifungal agents and highlights the plant and marine based compounds as a potential promising antifungal agents.

Fungal Cell Wall‐Graphene Oxide Microcomposite Membrane for Organic Solvent Nanofiltration

2021 ◽  
pp. 2100110
Author(s):  
Liyuan Zhang ◽  
Mengchen Zhang ◽  
Gongping Liu ◽  
Wanqin Jin ◽  
Xiaoyan Li
Keyword(s):  
Cell Wall ◽  
Graphene Oxide ◽  
Organic Solvent ◽  
Fungal Cell Wall ◽  
Fungal Cell ◽  
Organic Solvent Nanofiltration

The Fungal Cell Wall

2020 ◽  
pp. 3-29
Author(s):  
Vladimir Farkaš
Keyword(s):  
Cell Wall ◽  
Fungal Cell Wall ◽  
Fungal Cell
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