ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?

2017 ◽  
pp. 131-157 ◽  
Author(s):  
Felipe Cabral-Miranda ◽  
Claudio Hetz
Keyword(s):  
Er Stress ◽  
Neurodegenerative Disease ◽  
Effect Relationship

scholarly journals “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 756
Author(s):  
Aaron Lerner ◽  
Carina Benzvi
Keyword(s):  
Side Effects ◽  
Autoimmune Diseases ◽  
Neurodegenerative Disease ◽  
Potential Role ◽  
Molecular Mimicry ◽  
Narrative Review ◽  
Major Protein ◽  
Staple Food ◽  
Effect Relationship ◽  
Systemic Side Effects

Wheat is a most favored staple food worldwide and its major protein is gluten. It is involved in several gluten dependent diseases and lately was suggested to play a role in non-celiac autoimmune diseases. Its involvement in neurodegenerative conditions was recently suggested but no cause-and-effect relationship were established. The present narrative review expands on various aspects of the gluten-gut-brain axes events, mechanisms and pathways that connect wheat and gluten consumption to neurodegenerative disease. Gluten induced dysbiosis, increased intestinal permeabillity, enteric and systemic side effects, cross-reactive antibodies, and the sequence of homologies between brain antigens and gluten are highlighted. This combination may suggest molecular mimicry, alluding to some autoimmune aspects between gluten and neurodegenerative disease. The proverb of Hippocrates coined in 400 BC, “let food be thy medicine,” is critically discussed in the frame of gluten and potential neurodegeneration evolvement.

Iron and ER stress in neurodegenerative disease

BioMetals ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 837-845 ◽  
Author(s):  
Yiting Liu ◽  
James R. Connor
Keyword(s):  
Er Stress ◽  
Neurodegenerative Disease

Memory Processes, Aging, Cognitive Decline, and Neurodegenerative Diseases

2006 ◽  
Vol 11 (4) ◽  
pp. 304-311 ◽  
Author(s):  
Lars-Göran Nilsson
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Neurodegenerative Disease ◽  
Genetic Markers ◽  
Brain Activity ◽  
Memory Performance ◽  
Modeling And Simulations ◽  
Aging And Health ◽  
Explained Variance ◽  
Different Levels

This paper presents four domains of markers that have been found to predict later cognitive impairment and neurodegenerative disease. These four domains are (1) data patterns of memory performance, (2) cardiovascular factors, (3) genetic markers, and (4) brain activity. The critical features of each domain are illustrated with data from the longitudinal Betula Study on memory, aging, and health ( Nilsson et al., 1997 ; Nilsson et al., 2004 ). Up to now, early signs regarding these domains have been examined one by one and it has been found that they are associated with later cognitive impairment and neurodegenerative disease. However, it was also found that each marker accounts for only a very small part of the total variance, implying that single markers should not be used as predictors for cognitive decline or neurodegenerative disease. It is discussed whether modeling and simulations should be used as tools to combine markers at different levels to increase the amount of explained variance.

Induction of ER stress by variants of the prohormone convertase 1 (PCSK1)-gene

2013 ◽  
Vol 8 (S 01) ◽  
Author(s):  
S Behrendt ◽  
D Löffler ◽  
R Tauscher ◽  
A Körner
Keyword(s):  
Er Stress ◽  
Prohormone Convertase ◽  
Prohormone Convertase 1 ◽  
Pcsk1 Gene
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