Design of Alternative Live Attenuated Influenza Virus Vaccines

Author(s):  
Courtney Finch ◽  
Weizhong Li ◽  
Daniel R. Perez
2013 ◽  
Vol 87 (17) ◽  
pp. 9895-9903 ◽  
Author(s):  
C. L. Loving ◽  
K. M. Lager ◽  
A. L. Vincent ◽  
S. L. Brockmeier ◽  
P. C. Gauger ◽  
...  

2019 ◽  
Vol 90 (4) ◽  
Author(s):  
Shahinul Islam ◽  
Fan Zhou ◽  
Sarah Lartey ◽  
Kristin G. I. Mohn ◽  
Florian Krammer ◽  
...  

2015 ◽  
Vol 6 ◽  
Author(s):  
YanChun Peng ◽  
Beibei Wang ◽  
Kawsar Talaat ◽  
Ruth Karron ◽  
Timothy J. Powell ◽  
...  

2014 ◽  
Vol 89 (6) ◽  
pp. 3421-3426 ◽  
Author(s):  
Andrew Cox ◽  
Steven F. Baker ◽  
Aitor Nogales ◽  
Luis Martínez-Sobrido ◽  
Stephen Dewhurst

The live attenuated influenza virus vaccine (LAIV) is preferentially recommended for use in persons 2 through 49 years of age but has not been approved for children under 2 or asthmatics due to safety concerns. Therefore, increasing safety is desirable. Here we describe a murine LAIV with reduced pathogenicity that retains lethality at high doses and further demonstrate that we can enhance safetyin vivothrough mutations within NS1. This model may permit preliminary safety analysis of improved LAIVs.


Author(s):  
Yelvi Levani ◽  
Ayu Lidya Paramita

Influenza is an acute respiratory disease caused by influenza virus. Influenza can affect million people in every year and causing morbidity. Some of cases can be severe and need hospitalized, especially in elderly people. Influenza is an airborne disease and can spread rapidly. Every seasonal flu can be different because Influenza virus do mutation. Influenza vaccine can reduce morbidity and mortality. There are two types of influenza vaccine; live attenuated influenza virus (LAIV) and inactivated influenza virus (IIV). The newest type of influenza vaccine consists four types of virus (quadrivalent), therefore it gives more protection compared to the older one. Influeza vaccine is still recommended during pandemic COVID-19 because it can prevent co-infection between Influenza and COVID-19. In addition, it can reduce the morbidity and mortality during pandemic COVID-19.


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