Transcriptional Control of the Development and Function of Vα14i NKT Cells

2014 ◽  
pp. 51-81 ◽  
Author(s):  
Isaac Engel ◽  
Mitchell Kronenberg
Keyword(s):  
Transcriptional Control ◽  
Nkt Cells ◽  
And Function

Mesencephalic GABA neuronal development: no more on the other side of oblivion

2014 ◽  
Vol 5 (5) ◽  
pp. 371-382 ◽  
Author(s):  
Suyan Li ◽  
Sampada Joshee ◽  
Anju Vasudevan
Keyword(s):  
Transcriptional Control ◽  
Neuronal Development ◽  
Developmental Regulation ◽  
Molecular Characteristics ◽  
Psychiatric Illnesses ◽  
Neuronal Populations ◽  
Gaba Neurons ◽  
Recent Developments ◽  
And Function ◽  
The Brain

AbstractMidbrain GABA neurons, endowed with multiple morphological, physiological and molecular characteristics as well as projection patterns are key players interacting with diverse regions of the brain and capable of modulating several aspects of behavior. The diversity of these GABA neuronal populations based on their location and function in the dorsal, medial or ventral midbrain has challenged efforts to rapidly uncover their developmental regulation. Here we review recent developments that are beginning to illuminate transcriptional control of GABA neurons in the embryonic midbrain (mesencephalon) and discuss its implications for understanding and treatment of neurological and psychiatric illnesses.

scholarly journals Transcriptional Control of Brown and Beige Fat Development and Function

Obesity ◽  
2018 ◽  
Vol 27 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Suzanne N. Shapira ◽  
Patrick Seale
Keyword(s):  
Transcriptional Control ◽  
Beige Fat ◽  
And Function

scholarly journals TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 71001-71012 ◽  
Author(s):  
Yan Li ◽  
Qing Yu ◽  
Zhengguo Zhang ◽  
Jian Wang ◽  
Simin Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Autoimmune Diseases ◽  
Transcriptional Control ◽  
And Function ◽  
Th9 Cell

scholarly journals CD1d-Independent NKT Cells in β2-Microglobulin-Deficient Mice Have Hybrid Phenotype and Function of NK and T Cells

2004 ◽  
Vol 172 (10) ◽  
pp. 6115-6122 ◽  
Author(s):  
Motoi Maeda ◽  
Ashleen Shadeo ◽  
Anna M. MacFadyen ◽  
Fumio Takei
Keyword(s):  
T Cells ◽  
Nkt Cells ◽  
Β2 Microglobulin ◽  
And Function ◽  
Deficient Mice

scholarly journals Divergence of Eukaryotic Secretory Components: the Candida albicans Homolog of the Saccharomyces cerevisiae Sec20 Protein Is N Terminally Truncated, and Its Levels Determine Antifungal Drug Resistance and Growth

2001 ◽  
Vol 183 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Yvonne Weber ◽  
Uwe J. Santore ◽  
Joachim F. Ernst ◽  
Rolf K. Swoboda
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Transcriptional Control ◽  
Secretory Pathway ◽  
Sodium Dodecyl ◽  
Fungal Species ◽  
Gene Encoding ◽  
Vesicle Traffic ◽  
Antifungal Drug Resistance ◽  
And Function

ABSTRACT Sec20p is a component of the yeast Saccharomyces cerevisiae secretory pathway that does not have a close homolog in higher eukaryotic cells. To verify the function of Sec20p in other fungal species, we characterized the gene encoding a Sec20p homolog in the human fungal pathogen Candida albicans. The deduced protein has 27% identity with, but is missing about 100 N-terminal residues compared to S. cerevisiae Sec20p, which is part of the cytoplasmic tail interacting with the cytoplasmic protein Tip20p. Because a strain lacking both C. albicans SEC20alleles could not be constructed, we placed SEC20 under transcriptional control of two regulatable promoters, MET3pand PCK1p. Repression of SEC20 expression in these strains prevented (MET3p-SEC20 allele) or retarded (PCK1p-SEC20 allele) growth and led to the appearance of extensive intracellular membranes, which frequently formed stacks. Reduced SEC20 expression in the PCK1p-SEC20strain did not affect morphogenesis but led to a series of hypersensitivity phenotypes including supersensitivity to aminoglycoside antibiotics, to nystatin, to sodium dodecyl sulfate, and to cell wall inhibitors. These results demonstrate the occurrence and function of Sec20p in a fungal species other than S. cerevisiae, but the lack of the N-terminal domain and the apparent absence of a close TIP20 homolog in the C. albicans genome also indicate a considerable diversity in mechanisms of retrograde vesicle traffic in eukaryotes.

Abstract 217: Quaking Post-Transcriptionally Guides Monocyte Adhesion and Differentiation into the Pro-Inflammatory Macrophage

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Ruben G de Bruin ◽  
Lily Shiue ◽  
Anjana Djarmshi ◽  
Hetty C de Boer ◽  
Wai Yi Leung ◽  
...  
Keyword(s):  
Transcriptional Control ◽  
Rna Binding ◽  
Inflammatory Diseases ◽  
Human Monocyte ◽  
Human Macrophage ◽  
Monocyte Adhesion ◽  
Sequence Elements ◽  
Bound Sequence ◽  
Novel Target ◽  
And Function

A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce new transcription necessary for macrophage identity, but post-transcriptional control of human macrophage differentiation is less well understood. Here, we detail our discovery that levels of the RNA-binding protein Quaking (QKI) are low in monocytes of early atherosclerotic lesions, but abundant in macrophages of advanced plaques. Specific depletion of QKI protein impaired monocyte adhesion, migration and differentiation into macrophages, and lesion formation. RNA-seq and microarray analysis of human monocyte and macrophage transcriptomes, including those of a unique QKI haploinsufficient patient, reveal developmental changes in RNA levels and alternative splicing of RNA transcripts enriched in QKI-bound sequence elements. The importance of these transcripts and requirement for QKI during differentiation illustrates a central role for QKI in post-transcriptionally guiding macrophage identity and function. These studies implicate QKI as a novel target for therapeutic intervention in inflammatory diseases.

Frequency and function of circulating invariant NKT cells in autoimmune diabetes mellitus and thyroid diseases in Colombian patients

2009 ◽  
Vol 70 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Alejandro Roman-Gonzalez ◽  
Maria Eugenia Moreno ◽  
Juan Manuel Alfaro ◽  
Federico Uribe ◽  
Guillermo Latorre-Sierra ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Autoimmune Diabetes ◽  
Nkt Cells ◽  
Thyroid Diseases ◽  
Invariant Nkt Cells ◽  
And Function ◽  
Autoimmune Diabetes Mellitus
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