The Role of BTB-Zinc Finger Transcription Factors During T Cell Development and in the Regulation of T Cell-mediated Immunity

2014 ◽  
pp. 21-49 ◽  
Author(s):  
Wilfried Ellmeier ◽  
Ichiro Taniuchi
Keyword(s):  
Transcription Factors ◽  
T Cell ◽  
Zinc Finger ◽  
T Cell Development ◽  
Cell Development ◽  
Cell Mediated Immunity

scholarly journals Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions

2018 ◽  
Vol 9 ◽  
Author(s):  
Ana Rosa Pérez ◽  
Alexandre Morrot ◽  
Vinicius Frias Carvalho ◽  
Juliana de Meis ◽  
Wilson Savino
Keyword(s):  
T Cell ◽  
Chagas Disease ◽  
T Cell Development ◽  
Cell Development

The role of Tec family kinases in T cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 119-138 ◽  
Author(s):  
Julie A. Lucas ◽  
Andrew T. Miller ◽  
Luana O. Atherly ◽  
Leslie J. Berg
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

1994 ◽  
Vol 14 (11) ◽  
pp. 7111-7123
Author(s):  
K Hahm ◽  
P Ernst ◽  
K Lo ◽  
G S Kim ◽  
C Turck ◽  
...  
Keyword(s):  
Amino Acid ◽  
T Cell ◽  
Dna Binding ◽  
Amino Acid Sequence ◽  
Zinc Finger ◽  
T Cell Development ◽  
Cell Development ◽  
Control Element ◽  
Early Stages ◽  
Alternatively Spliced

The lymphocyte-specific DNA-binding protein LyF-1 interacts with a critical control element in the terminal deoxynucleotidyltransferase (TdT) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. We have purified LyF-1 and have obtained a partial amino acid sequence from proteolytic peptides. The amino acid sequence suggests that LyF-1 is a zinc finger protein encoded by the Ikaros gene, which previously was implicated in T-cell development. Recombinant Ikaros expressed in Escherichia coli bound to the TdT promoter, and antisera directed against the recombinant protein specifically blocked the DNA-binding activity of LyF-1 in crude extracts. Further analysis revealed that at least six distinct mRNAs are derived from the Ikaros/LyF-1 gene by alternative splicing. Only two of the isoforms possess the N-terminal zinc finger domain that is necessary and sufficient for TdT promoter binding. Although both of these isoforms bound to similar sequences in the TdT, lambda 5, VpreB, and lck promoters, one isoform contains an additional zinc finger that resulted in altered recognition of some binding sites. At least four of the Ikaros/LyF-1 isoforms were detectable in extracts from B- and T-cell lines, with the relative amounts of the isoforms varying considerably. These data reveal that the LyF-1 protein is encoded by specific mRNAs derived from the alternatively-spliced Ikaros gene, suggesting that this gene may be important for the early stages of both B- and T-lymphocyte development.

scholarly journals Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134100 ◽  
Author(s):  
Heather L. Evans-Marin ◽  
Anthony T. Cao ◽  
Suxia Yao ◽  
Feidi Chen ◽  
Chong He ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Regulatory Role

scholarly journals The TCF-1 and LEF-1 Transcription Factors Have Cooperative and Opposing Roles in T Cell Development and Malignancy

Immunity ◽  
2014 ◽  
Vol 40 (1) ◽  
pp. 166
Author(s):  
Shuyang Yu ◽  
Xinyuan Zhou ◽  
Farrah C. Steinke ◽  
Chengyu Liu ◽  
Shann-Ching Chen ◽  
...  
Keyword(s):  
Transcription Factors ◽  
T Cell ◽  
T Cell Development ◽  
Cell Development

scholarly journals Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Mark Engel ◽  
Tom Sidwell ◽  
Ajithkumar Vasanthakumar ◽  
George Grigoriadis ◽  
Ashish Banerjee
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
T Cell ◽  
Regulatory T Cells ◽  
Immune Tolerance ◽  
Regulatory T Cell ◽  
T Cell Development ◽  
Signalling Pathways ◽  
Treg Development

Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.

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