Systems Biology Approach for New Target and Biomarker Identification

Current Topics in Microbiology and Immunology - Systems Biology ◽

10.1007/82_2012_252 ◽

2012 ◽

pp. 169-199

Author(s):

I-Ming Wang ◽

David J. Stone ◽

David Nickle ◽

Andrey Loboda ◽

Oscar Puig ◽

...

Keyword(s):

Systems Biology ◽

Biomarker Identification

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Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for clinical response biomarker identification

Journal for ImmunoTherapy of Cancer ◽

10.1186/2051-1426-1-s1-p257 ◽

2013 ◽

Vol 1 (S1) ◽

Author(s):

Drew Hotson ◽

Ryan Alvarado ◽

Andrew Conroy ◽

Santosh Putta ◽

Ester Simeone ◽

...

Keyword(s):

Systems Biology ◽

Clinical Response ◽

Peripheral Blood Mononuclear Cells ◽

Peripheral Blood ◽

Mononuclear Cells ◽

Peripheral Blood Mononuclear ◽

Biomarker Identification ◽

Blood Mononuclear Cells ◽

Response Biomarker ◽

Melanoma Patients

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Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification

Biomarker Research ◽

10.1186/s40364-016-0077-0 ◽

2016 ◽

Vol 4 (1) ◽

Cited By ~ 10

Author(s):

Protus Arrey Tarkang ◽

Regina Appiah-Opong ◽

Michael F. Ofori ◽

Lawrence S. Ayong ◽

Alexander K. Nyarko

Keyword(s):

Systems Biology ◽

Drug Discovery ◽

Biomarker Identification

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Psychiatric Disorders Biomarker Identification: from Proteomics to Systems Biology

Pharmacopsychiatry ◽

10.1055/s-2008-1081483 ◽

2008 ◽

Vol 41 (S 01) ◽

pp. S70-S77 ◽

Cited By ~ 13

Author(s):

S. Reckow ◽

P. Gormanns ◽

F. Holsboer ◽

C. Turck

Keyword(s):

Systems Biology ◽

Psychiatric Disorders ◽

Biomarker Identification

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Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for response biomarker identification

Journal of Translational Medicine ◽

10.1186/1479-5876-12-s1-o13 ◽

2014 ◽

Vol 12 (Suppl 1) ◽

pp. O13 ◽

Cited By ~ 1

Author(s):

Drew Hotson ◽

Ryan Alvarado ◽

Andy Conroy ◽

Santosh Putta ◽

Ester Simeone ◽

...

Keyword(s):

Systems Biology ◽

Peripheral Blood Mononuclear Cells ◽

Peripheral Blood ◽

Mononuclear Cells ◽

Peripheral Blood Mononuclear ◽

Immune Signaling ◽

Biomarker Identification ◽

Blood Mononuclear Cells ◽

Response Biomarker ◽

Melanoma Patients

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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

Behavioral and Brain Sciences ◽

10.1017/s0140525x18002911 ◽

2019 ◽

Vol 42 ◽

Author(s):

J. Alfredo Blakeley-Ruiz ◽

Carlee S. McClintock ◽

Ralph Lydic ◽

Helen A. Baghdoyan ◽

James J. Choo ◽

...

Keyword(s):

Systems Biology ◽

High Resolution ◽

Experimental Design ◽

Integrated Systems ◽

Microbiome Research ◽

Constructive Criticism

Abstract The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

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