The Role and Contributions of Systems Biology to the Non-Human Primate Model of Influenza Pathogenesis and Vaccinology

2012 ◽  
pp. 69-85
Author(s):  
Carole Baskin
Keyword(s):  
Systems Biology ◽  
Primate Model ◽  
Human Primate

Cardiac Pacing in a Chronically Instrumented Non-Human Primate Model During Centrifuge,

1996 ◽  
Author(s):  
S. C. Koenig ◽  
Craig Reister ◽  
J. Schtaub ◽  
Gary Muniz ◽  
Tim Fergusan
Keyword(s):  
Cardiac Pacing ◽  
Primate Model ◽  
Human Primate

Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model

Life Sciences ◽  
2021 ◽  
Vol 276 ◽  
pp. 119374
Author(s):  
Roghayeh Navabi ◽  
Babak Negahdari ◽  
Ensiyeh Hajizadeh-Saffar ◽  
Mostafa Hajinasrollah ◽  
Yaser Jenab ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Receptor Agonist ◽  
Combined Therapy ◽  
Primate Model ◽  
Human Primate

scholarly journals Neonatal Immune System Ontogeny: The Role of Maternal Microbiota and Associated Factors. How Might the Non-Human Primate Model Enlighten the Path?

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 584
Author(s):  
Natalia Nunez ◽  
Louis Réot ◽  
Elisabeth Menu
Keyword(s):  
Immune System ◽  
Mode Of Delivery ◽  
Microbial Colonization ◽  
Therapeutic Interventions ◽  
Primate Model ◽  
Neonatal Immune System ◽  
Gastrointestinal Colonization ◽  
The Impact ◽  
Human Primate

Interactions between the immune system and the microbiome play a crucial role on the human health. These interactions start in the prenatal period and are critical for the maturation of the immune system in newborns and infants. Several factors influence the composition of the infant’s microbiota and subsequently the development of the immune system. They include maternal infection, antibiotic treatment, environmental exposure, mode of delivery, breastfeeding, and food introduction. In this review, we focus on the ontogeny of the immune system and its association to microbial colonization from conception to food diversification. In this context, we give an overview of the mother–fetus interactions during pregnancy, the impact of the time of birth and the mode of delivery, the neonate gastrointestinal colonization and the role of breastfeeding, weaning, and food diversification. We further review the impact of the vaccination on the infant’s microbiota and the reciprocal case. Finally, we discuss several potential therapeutic interventions that might help to improve the newborn and infant’s health and their responses to vaccination. Throughout the review, we underline the main scientific questions that are left to be answered and how the non-human primate model could help enlighten the path.

scholarly journals Combination therapy protects macaques against advanced Marburg virus disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Robert W. Cross ◽  
Zachary A. Bornholdt ◽  
Abhishek N. Prasad ◽  
Viktoriya Borisevich ◽  
Krystle N. Agans ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Rhesus Monkeys ◽  
Viral Infections ◽  
Virus Disease ◽  
Marburg Virus ◽  
Therapeutic Window ◽  
Post Inoculation ◽  
Primate Model ◽  
Lethal Infection ◽  
Human Primate

AbstractMonoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2. One of the major challenges of acute viral infections is the treatment of advanced disease. Thus, extending the window of therapeutic intervention is critical. Here, we explore the benefit of combination therapy with a mAb and remdesivir in a non-human primate model of Marburg virus (MARV) disease. While rhesus monkeys are protected against lethal infection when treatment with either a human mAb (MR186-YTE; 100%), or remdesivir (80%), is initiated 5 days post-inoculation (dpi) with MARV, no animals survive when either treatment is initiated alone beginning 6 dpi. However, by combining MR186-YTE with remdesivir beginning 6 dpi, significant protection (80%) is achieved, thereby extending the therapeutic window. These results suggest value in exploring combination therapy in patients presenting with advanced filovirus disease.

scholarly journals Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations

2017 ◽  
Vol 140 ◽  
pp. 95-105 ◽  
Author(s):  
Géraldine Piorkowski ◽  
Frédéric Jacquot ◽  
Gilles Quérat ◽  
Caroline Carbonnelle ◽  
Delphine Pannetier ◽  
...  
Keyword(s):  
Primate Model ◽  
Cynomolgus Macaques ◽  
Human Primate

Direct activation of natural killer T cells induces airway hyperreactivity in a non-human primate model of asthma

2007 ◽  
Vol &NA; ◽  
pp. S8
Author(s):  
Ponpan Matangkasombut ◽  
Muriel Pichavant ◽  
Takahiro Yasumi ◽  
Carrie Hendricks ◽  
Rosemarie H. DeKruyff ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
Airway Hyperreactivity ◽  
Primate Model ◽  
Direct Activation ◽  
Killer T Cells ◽  
Human Primate ◽  
Natural Killer T

scholarly journals Evaluation of a Sustained-Release Prednisolone Acetate Biodegradable Subconjunctival Implant in a Non-Human Primate Model

2017 ◽  
Vol 6 (5) ◽  
pp. 9 ◽  
Author(s):  
Yu-Chi Liu ◽  
Anthony Herr Cheun Ng ◽  
Xu Wen Ng ◽  
Peng Yan ◽  
Subbu S. Venkatraman ◽  
...  
Keyword(s):  
Sustained Release ◽  
Prednisolone Acetate ◽  
Primate Model ◽  
Human Primate

P1-235: Effects of the novel histamine H3 receptor antagonist S 38093 in a non-human primate model of cognitive dysfunction

2009 ◽  
Vol 5 (4S_Part_8) ◽  
pp. P245-P245
Author(s):  
Jay S. Schneider ◽  
Emmanuel Decamp ◽  
Michael Hill ◽  
Erwan Bezard ◽  
Alan Crossman ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
The Novel ◽  
Primate Model ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Primate ◽  
Histamine H3
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