TIM-3 and Its Regulatory Role in Immune Responses

2010 ◽  
pp. 1-15 ◽  
Author(s):  
Chen Zhu ◽  
Ana C. Anderson ◽  
Vijay K. Kuchroo
Keyword(s):  
Immune Responses ◽  
Regulatory Role

Dendritic cells and macrophages in the pituitary and the gonads. Evidence for their role in the fine regulation of the reproductive endocrine response

1997 ◽  
Vol 136 (1) ◽  
pp. 8-24 ◽  
Author(s):  
A Hoek ◽  
W Allaerts ◽  
PJM Leenen ◽  
J Schoemaker ◽  
HA Drexhage
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Endocrine Cells ◽  
Regulatory Role ◽  
Blood Monocytes ◽  
Endocrine Response ◽  
Signalling Molecules ◽  
Reproductive Endocrine ◽  
Fine Regulation

Abstract Blood monocytes are able to mature into macrophages as well as into dendritic cells. Dendritic cells and macrophages have mainly been studied for their function in the immune response, e.g. in the presentation of antigens to lymphocytes and in the phagocytosis/degradation of unwanted material. The cells are also, however, important producers of a variety of signalling molecules and hormones and are thus involved in other physiological functions such as wound healing, the regulation of the microcirculation and the regulation of the function and growth of endocrine cells. This review summarizes the existing evidence for a regulatory role of dendritic cells and macrophages in the function and growth of hormone-producing cells of the pituitary–gonadal axis. It focusses on the presence, localization and phenotype of dendritic cells and macrophages in the anterior pituitary and the gonads, the endocrine regulatory role of cytokines produced by these cells and the existence of putative feedback mechanisms between endocrine cells of the pituitary–gonadal axis and dendritic cells and macrophages. The recognition of a 'floating endocrine-regulatory force' of monocyte-derived cells that also plays a role in the initiation of immune responses has implications for our understanding of the pathogenesis of gonadal and pituitary autoimmune reactions. European Journal of Endocrinology 136 8–24

scholarly journals Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Samanta Melgar-Rodríguez ◽  
Emilio A. Cafferata ◽  
Nicolás I. Díaz ◽  
Miguel A. Peña ◽  
Luis González-Osuna ◽  
...  
Keyword(s):  
Immune Responses ◽  
Natural Killer ◽  
Inflammatory Diseases ◽  
Nkt Cells ◽  
Regulatory Role ◽  
Th17 Lymphocytes ◽  
Antigen Presenting ◽  
Potential Regulatory Role ◽  
Natural Killer T

Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocytes, respectively. Recently, a new subgroup of NKT cells termed NKT10 has been described, which cooperates and interacts with other immune cells to promote immunoregulatory responses. Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.

Essential regulatory role of NOX2 in RIG-I-mediated innate immune responses

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 19
Author(s):  
Nathalie Grandvaux ◽  
Anton Soucy-Faulkner ◽  
Karin Fink ◽  
Alexis Martel ◽  
Loubna Jouan ◽  
...  
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Regulatory Role ◽  
Innate Immune Responses

THE REGULATORY ROLE OF ACUTE PHASE REACTANTS ON HUMAN IMMUNE RESPONSES

1982 ◽  
Vol 389 (1 C-Reactive Pr) ◽  
pp. 456-456 ◽  
Author(s):  
J. J. Li ◽  
K. P. W. J. McAdam ◽  
L. L. Bausserman
Keyword(s):  
Immune Responses ◽  
Acute Phase ◽  
Regulatory Role ◽  
Acute Phase Reactants ◽  
Human Immune

Specific humoral immune responses in 12 cases of food sensitization to sesame seed

1997 ◽  
Vol 27 (11) ◽  
pp. 1285-1291 ◽  
Author(s):  
M. N. KOLOPP-SARDA ◽  
D. A. MONERET-VAUTRIN ◽  
B. GOBERT ◽  
G. KANNY ◽  
M. BRODSCHII ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sesame Seed ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Food Sensitization
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