Oncogenic Mutations of PIK3CA in Human Cancers

Current Topics in Microbiology and Immunology - Phosphoinositide 3-kinase in Health and Disease ◽

10.1007/82_2010_68 ◽

2010 ◽

pp. 21-41 ◽

Cited By ~ 37

Author(s):

Yardena Samuels ◽

Todd Waldman

Keyword(s):

Human Cancers ◽

Oncogenic Mutations

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Genetic Engineering of Zebrafish in Cancer Research

Cancers ◽

10.3390/cancers12082168 ◽

2020 ◽

Vol 12 (8) ◽

pp. 2168

Author(s):

Ludivine Raby ◽

Pamela Völkel ◽

Xuefen Le Bourhis ◽

Pierre-Olivier Angrand

Keyword(s):

Genetic Alterations ◽

Therapeutic Strategies ◽

Molecular Signatures ◽

Reverse Genetic ◽

Human Cancers ◽

Oncogenic Mutations ◽

Cancer Models ◽

Conditional Expression ◽

Cancer Initiation

Zebrafish (Danio rerio) is an excellent model to study a wide diversity of human cancers. In this review, we provide an overview of the genetic and reverse genetic toolbox allowing the generation of zebrafish lines that develop tumors. The large spectrum of genetic tools enables the engineering of zebrafish lines harboring precise genetic alterations found in human patients, the generation of zebrafish carrying somatic or germline inheritable mutations or zebrafish showing conditional expression of the oncogenic mutations. Comparative transcriptomics demonstrate that many of the zebrafish tumors share molecular signatures similar to those found in human cancers. Thus, zebrafish cancer models provide a unique in vivo platform to investigate cancer initiation and progression at the molecular and cellular levels, to identify novel genes involved in tumorigenesis as well as to contemplate new therapeutic strategies.

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Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB)

The Analyst ◽

10.1039/c5an01863c ◽

2016 ◽

Vol 141 (2) ◽

pp. 393-402 ◽

Cited By ~ 19

Author(s):

Michael Tu ◽

David Chia ◽

Fang Wei ◽

David Wong

Keyword(s):

Electric Field ◽

Liquid Biopsy ◽

Clinical Applications ◽

Human Cancers ◽

Oncogenic Mutations ◽

Analytical Strategies

This paper will review the analytical strategies used to assess oncogenic mutations from biofluid samples. Clinical applications will also be discussed.

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