From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development

2010 ◽  
pp. 209-239 ◽  
Author(s):  
Saveur-Michel Maira ◽  
Peter Finan ◽  
Carlos Garcia-Echeverria
Keyword(s):  
Pi3k Pathway ◽  
Clinical Development

scholarly journals Current clinical development of PI3K pathway inhibitors in glioblastoma

2012 ◽  
Vol 14 (7) ◽  
pp. 819-829 ◽  
Author(s):  
P. Y. Wen ◽  
E. Q. Lee ◽  
D. A. Reardon ◽  
K. L. Ligon ◽  
W. K. Alfred Yung
Keyword(s):  
Pi3k Pathway ◽  
Clinical Development

scholarly journals L6.3 Molecular Characterization and Pre-Screening Process in Early Drug Clinical Development of PI3K-Pathway Inhibitors

2012 ◽  
Vol 23 ◽  
pp. v9-v10
Author(s):  
J. Rodon ◽  
R. Dienstmann ◽  
J. Cortes ◽  
C. Saura ◽  
C. Aura ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Pi3k Pathway ◽  
Clinical Development ◽  
Screening Process ◽  
Early Drug

scholarly journals Inhibitors in AKTion: ATP-competitive vs allosteric

2020 ◽  
Vol 48 (3) ◽  
pp. 933-943
Author(s):  
Glorianne Lazaro ◽  
Eleftherios Kostaras ◽  
Igor Vivanco
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Pi3k Pathway ◽  
Clinical Development ◽  
Future Prospects ◽  
Therapeutic Targeting ◽  
Human Tumours ◽  
Drug Classes ◽  
Context Specific ◽  
Oncogenic Function

Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly classified as either ATP-competitive or allosteric, are currently in various stages of clinical development. Herein, we review the evidence for AKT dependence in human tumours and focus on its therapeutic targeting by the two drug classes. We highlight the future prospects for the development and implementation of more effective context-specific AKT inhibitors aided by our increasing knowledge of both its regulation and some previously unrecognised non-canonical functions.

COVID-19 must catalyse changes to clinical development

2020 ◽  
Vol 19 (10) ◽  
pp. 653-654
Author(s):  
Rod MacKenzie ◽  
Peter Honig ◽  
Judy Sewards ◽  
Robert Goodwin ◽  
Marie-Pierre Hellio
Keyword(s):  
Clinical Development

Curcumin: New trends in the formulative and clinical development

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Morazzoni ◽  
A Riva ◽  
M Ronchi ◽  
G Petrangolini ◽  
W Cabri
Keyword(s):  
Clinical Development
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