Chemokine Decoy Receptors: Structure–Function and Biological Properties

2010 ◽  
pp. 15-36 ◽  
Author(s):  
Raffaella Bonecchi ◽  
Benedetta Savino ◽  
Elena M. Borroni ◽  
Alberto Mantovani ◽  
Massimo Locati
Keyword(s):  
Structure Function ◽  
Biological Properties ◽  
Decoy Receptors

Review: Structure–function and biological properties of the atypical chemokine receptor D6

2013 ◽  
Vol 55 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Cinzia Cancellieri ◽  
Nicoletta Caronni ◽  
Alessandro Vacchini ◽  
Benedetta Savino ◽  
Elena M. Borroni ◽  
...  
Keyword(s):  
Structure Function ◽  
Chemokine Receptor ◽  
Biological Properties

Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains

2005 ◽  
Vol 289 (5) ◽  
pp. L777-L787 ◽  
Author(s):  
Pedro Faisca ◽  
Dao Bui Tran Anh ◽  
Daniel J.-M. Desmecht
Keyword(s):  
Structure Function ◽  
Positional Cloning ◽  
Sendai Virus ◽  
Laboratory Mouse ◽  
Inbred Strains ◽  
Biological Properties ◽  
Mouse Strains ◽  
Viral Loads ◽  
Lung Structure ◽  
Inbred Strains Of Mice

The Paramyxoviridae family includes some of the most important and ubiquitous disease-causing viruses of infants and children, most of which cause significant infections of the respiratory tract. Evidence is accumulating in humans that genetic factors are involved in the severity of clinical presentation. As a first step toward the identification of the genes involved, this study was undertaken to establish whether laboratory mouse strains differ in susceptibility to Sendai virus, the murine counterpart of human type-1 parainfluenza virus which, historically, has been used extensively in studies that have defined the basic biological properties of paramyxoviruses in general. With this purpose in mind, double-chamber plethysmography data were collected daily for 7 days after inoculation of Sendai virus in six inbred strains of mice. In parallel, histological examinations and lung viral titration were carried out from day 5 to day 7 after inoculation. Pulmonary structure/function values closely reflected the success of viral replication in the lungs and revealed a pattern of continuous variation with resistant, intermediate, and susceptible strains. The results unambiguously suggest that BALB/c (resistant) and 129Sv (susceptible) strains should be used in crossing experiments aimed at identifying the genes involved in resistance to Paramyxoviridae by the positional cloning approach.

scholarly journals Chemo-enzymatic synthesis of 3-O- (β-d-glycopyranosyl)-sn-glycerols and their evaluation as preservative in cosmetics

2017 ◽  
Vol 89 (9) ◽  
pp. 1295-1304 ◽  
Author(s):  
Laure Guillotin ◽  
Perrine Cancellieri ◽  
Pierre Lafite ◽  
Ludovic Landemarre ◽  
Richard Daniellou
Keyword(s):  
Economic Development ◽  
Natural Products ◽  
Chemical Synthesis ◽  
Structure Function ◽  
Enzymatic Synthesis ◽  
Challenge Test ◽  
Biological Properties ◽  
Test Method ◽  
Dictyoglomus Thermophilum

Abstractd-Glycopyranosyl glycerols are common natural products and exhibit strong biological properties, notably as moisturizing agents in cosmetics. Their chemical synthesis remains tedious thus decreasing their potential industrial and economic development, as well as the study of their structure-function relationships. In this work, the chemo-enzymatic synthesis of three enantiopure 3-O-(β-d-glycopyranosyl)-sn-glycerols was efficiently performed using an original glycosidase from Dictyoglomus thermophilum and their preservatives properties were assessed using a challenge test method. Amongst them, the 3-O-(β-d-glucopyranosyl)-sn-glycerol exhibited a specific anti-fungus activity.

scholarly journals Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 505 ◽  
Author(s):  
Tatiana V. Ovchinnikova
Keyword(s):  
Product Development ◽  
Structure Function ◽  
Bioactive Peptides ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Marine Organisms

In recent years, bioactive peptides from marine organisms have gained increasing attention in the field of pharmaceutical, cosmeceutical, and nutraceutical product development owing to their interesting biological properties [...]

Three Dimensional structure and organization of diploid chromosomes by optical section microscopy

1987 ◽  
Vol 45 ◽  
pp. 633-635
Author(s):  
David A. Agard ◽  
Yasushi Hiraoka ◽  
John W. Sedat
Keyword(s):  
Dimensional Space ◽  
Three Dimensional ◽  
Developmental State ◽  
Mitotic Cell ◽  
Biological Properties ◽  
Dimensional Structure ◽  
Specific Gene ◽  
Three Dimensional Structure ◽  
Complementary Techniques ◽  
Dynamic Structures

In an effort to understand the complex relationship between structure and biological function within the nucleus, we have embarked on a program to examine the three-dimensional structure and organization of Drosophila melanogaster embryonic chromosomes. Our overall goal is to determine how DNA and proteins are organized into complex and highly dynamic structures (chromosomes) and how these chromosomes are arranged in three dimensional space within the cell nucleus. Futher, we hope to be able to correlate structual data with such fundamental biological properties as stage in the mitotic cell cycle, developmental state and transcription at specific gene loci.Towards this end, we have been developing methodologies for the three-dimensional analysis of non-crystalline biological specimens using optical and electron microscopy. We feel that the combination of these two complementary techniques allows an unprecedented look at the structural organization of cellular components ranging in size from 100A to 100 microns.

Membrane–cytoskeleton interactions in cholesterol-dependent domain formation

2015 ◽  
Vol 57 ◽  
pp. 177-187 ◽  
Author(s):  
Jennifer N. Byrum ◽  
William Rodgers
Keyword(s):  
Biological Properties ◽  
Membrane Rafts ◽  
Membrane Domains ◽  
Biological Functions ◽  
Membrane Cytoskeleton ◽  
Heterogeneous Structures ◽  
Integral Role ◽  
Model Cell ◽  
Actomyosin Cytoskeleton ◽  
Dependent Domain

Since the inception of the fluid mosaic model, cell membranes have come to be recognized as heterogeneous structures composed of discrete protein and lipid domains of various dimensions and biological functions. The structural and biological properties of membrane domains are represented by CDM (cholesterol-dependent membrane) domains, frequently referred to as membrane ‘rafts’. Biological functions attributed to CDMs include signal transduction. In T-cells, CDMs function in the regulation of the Src family kinase Lck (p56lck) by sequestering Lck from its activator CD45. Despite evidence of discrete CDM domains with specific functions, the mechanism by which they form and are maintained within a fluid and dynamic lipid bilayer is not completely understood. In the present chapter, we discuss recent advances showing that the actomyosin cytoskeleton has an integral role in the formation of CDM domains. Using Lck as a model, we also discuss recent findings regarding cytoskeleton-dependent CDM domain functions in protein regulation.

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