The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease

2016 ◽  
pp. 265-277 ◽  
Author(s):  
Darin J. Knapp ◽  
George R. Breese
Keyword(s):  
Rodent Model ◽  
6 Hydroxydopamine

scholarly journals Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Janet Barroso-Flores ◽  
Marco A. Herrera-Valdez ◽  
Violeta Gisselle Lopez-Huerta ◽  
Elvira Galarraga ◽  
José Bargas
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Voltage ◽  
Rodent Model ◽  
Inhibitory Synapses ◽  
Projection Neurons ◽  
Striatal Neurons ◽  
Dopamine Depletion ◽  
Short Term ◽  
6 Hydroxydopamine

Most neurons in the striatum are projection neurons (SPNs) which make synapses with each other within distances of approximately 100 µm. About 5% of striatal neurons are GABAergic interneurons whose axons expand hundreds of microns. Short-term synaptic plasticity (STSP) between fast-spiking (FS) interneurons and SPNs and between SPNs has been described with electrophysiological and optogenetic techniques. It is difficult to obtain pair recordings from some classes of interneurons and due to limitations of actual techniques, no other types of STSP have been described on SPNs. Diverse STSPs may reflect differences in presynaptic release machineries. Therefore, we focused the present work on answering two questions: Are there different identifiable classes of STSP between GABAergic synapses on SPNs? And, if so, are synapses exhibiting different classes of STSP differentially affected by dopamine depletion? Whole-cell voltage-clamp recordings on SPNs revealed three classes of STSPs: depressing, facilitating, and biphasic (facilitating-depressing), in response to stimulation trains at 20 Hz, in a constant ionic environment. We then used the 6-hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease to show that synapses with different STSPs are differentially affected by dopamine depletion. We propose a general model of STSP that fits all the dynamics found in our recordings.

Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease

2011 ◽  
Vol 133 (2) ◽  
pp. 773-779 ◽  
Author(s):  
Harquin Simplice Foyet ◽  
Lucian Hritcu ◽  
Alin Ciobica ◽  
Marius Stefan ◽  
Pierre Kamtchouing ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Methanolic Extract ◽  
Memory Deficits ◽  
Rodent Model ◽  
6 Hydroxydopamine

Adolescent Amphetamine Conditioned Place Preference in a Rodent Model of Psychosis

2010 ◽  
Author(s):  
Daniel M. Noel ◽  
Tammy J. Sluder ◽  
Julia Lehmann ◽  
Jamie D. Whittemore ◽  
Russell W. Brown
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Rodent Model

Nicotine sensitization and its effects on dopamine overflow in a rodent model of schizophrenia

2011 ◽  
Author(s):  
Marla K. Perna ◽  
Meredith L. Smith ◽  
Russell W. Brown
Keyword(s):  
Rodent Model
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