Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms

2016 ◽  
pp. 31-44 ◽  
Author(s):  
Lucile Capuron ◽  
Nathalie Castanon
Keyword(s):  
Neuropsychiatric Symptom ◽  
Symptom Domains

scholarly journals Executive Dysfunction and Language Deficits in a Pediatric Patient with OCD and MDD with Suicidality

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Melissa Yuan
Keyword(s):  
Executive Function ◽  
Psychiatric Disorders ◽  
Pediatric Patient ◽  
Executive Dysfunction ◽  
Language Deficits ◽  
Suicidal Thoughts ◽  
Neuropsychological Measures ◽  
Symptom Domains

The role of neuropsychiatric testing in psychiatric disorders is becoming more prominent. Neuropsychological measures that are similar across symptom domains and phenomena such as suicidality may help clinicians guide treatment and tailor therapies to the patient in the most effective way possible. We report the case of a 16-year-old girl who presented with bizarre, intrusive suicidal thoughts in the setting of OCD and MDD. This case is unusual in that we have accurate neuropsychological determination of our patient’s language and executive function deficits, and we propose a link between them and her expression of suicidality in the context of OCD and MDD.

scholarly journals Aging as a Context for the Role of Inflammation in Depressive Symptoms

2021 ◽  
Vol 11 ◽  
Author(s):  
Kelci Straka ◽  
Mai-Lan Tran ◽  
Summer Millwood ◽  
James Swanson ◽  
Kate Ryan Kuhlman
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Inflammatory Markers ◽  
Community Sample ◽  
Depression Scale ◽  
Interpersonal Problems ◽  
Well Being ◽  
Somatic Complaints ◽  
Symptom Domains

Inflammation has been implicated in the pathogenesis and maintenance of depressive symptoms. The role of inflammation in depressive symptomatology may be complex, varying within endophenotypes and across the lifespan. Aging is associated with myriad changes in the structure and function of the brain. Yet, little attention has been given to the role of inflammation in depressive symptoms within a lifespan developmental framework. In this study, we examined whether the association between inflammation and depressive symptom domains varied by age. Participants were a community sample of individuals (N = 2,077, Range = 30–84) who participated in the Biomarker projects of the MIDUS2, MIDUS Refresher, or the MIDJA study. Inflammation was indexed by two inflammatory markers consistently implicated in depressed individuals, interleukin 6 (IL-6) and C-reactive protein (CRP), measured in blood. Depressive symptom domains, including depressed affect, anhedonia, somatic complaints, and interpersonal problems, were reported via the Center for Epidemiologic Studies—Depression Scale (CES-D). Inflammatory markers were associated with more somatic complaints, more interpersonal problems, and less anhedonia. Age moderated the relationship between inflammatory markers and two depressive symptom subscales. Specifically, the positive association between inflammation and somatic complaints and the negative association between inflammation and anhedonia increased with age. These observations offer preliminary evidence from a large community sample that aging may be an important context for the role of inflammatory signaling in different aspects of psychological and behavioral well-being.

Psychopathology and friendship in children and adolescents: disentangling the role of co-occurring symptom domains with serial mediation models

2017 ◽  
Vol 26 (11) ◽  
pp. 1377-1386
Author(s):  
Arthur Gus Manfro ◽  
Pedro M. Pan ◽  
Ary Gadelha ◽  
Marcelo Fleck ◽  
Maria C. do Rosário ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Symptom Domains ◽  
Serial Mediation ◽  
Mediation Models

scholarly journals P1-279: THE ROLE OF NEUROPSYCHIATRIC SYMPTOM IN PREDICTING THE CONVERSION FROM MILD COGNITIVE IMPAIRMENT TO ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P348-P349
Author(s):  
Tsz Wai Bentley Lo ◽  
Wael K. Karameh ◽  
Joseph Barfett ◽  
David G. Munoz ◽  
Tom A. Schweizer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychiatric Symptom

Inflammatory Bases of Neuropsychiatric Symptom Domains: Mechanisms and Specificity

2021 ◽  
pp. 335-353
Author(s):  
Bruno Aouizerate ◽  
Sylvie Vancassel ◽  
Nathalie Castanon ◽  
Lucile Capuron
Keyword(s):  
Neuropsychiatric Symptom ◽  
Symptom Domains

RESPONSIBILITY ATTITUDES AND DIFFERENT TYPES OF OBSESSIVE-COMPULSIVE SYMPTOMS IN A STUDENT POPULATION

2003 ◽  
Vol 31 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Jakob Smári ◽  
Thórhildur Gylfadóttir ◽  
Gudrún Lind Halldórsdóttir
Keyword(s):  
Partial Correlation ◽  
Cognitive Theory ◽  
Cognitive Factor ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Symptom ◽  
Symptom Domains ◽  
Different Types ◽  
Obsessive Compulsive Symptom

Excessive responsibility has been proposed as a cognitive factor in obsessive-compulsive symptoms. In the present study the relationships of Salkovskis' measure of Responsibility Attitudes (RAS) (Salkovskis et al., 2000) with the total scale and the subscales of the PI-WSUR (Burns, Koertge, Formea, & Sternberger, 1996) measure of obsessive compulsive symptoms, as well as with a measure of depression (CES-D), were studied with a sample of 356 students (108 males and 248 females). As expected, the correlation between RAS and PI-WSUR was stronger than the correlation between RAS and CES-D, supporting the specific role of excessive responsibility in obsessive-compulsive symptoms. Among the subscales of PI-SWUR the strongest correlation of RAS was with Obsessional Thoughts About Harm to Self/Others (OTAHSO) and then with Checking. The OTAHSO was the only PI-WSUR subscale to show a significant partial correlation with RAS when other subscales and CES-D scores were taken into consideration. These results indicate that responsibility attitudes may play quite different roles in relation to different obsessive-compulsive symptom domains and that cognitive theory should take this more explicitly into account.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management
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