Helminth Therapy for MS

2014 ◽  
pp. 195-220 ◽  
Author(s):  
Radu Tanasescu ◽  
Cris S. Constantinescu
Keyword(s):  
Helminth Therapy

Special issue: Translatability of helminth therapy

2013 ◽  
Vol 43 (3-4) ◽  
pp. 189 ◽  
Author(s):  
David Artis ◽  
Edward J. Pearce
Keyword(s):  
Special Issue ◽  
Helminth Therapy

Helminth therapy for autism under gut-brain axis- hypothesis

2019 ◽  
Vol 125 ◽  
pp. 110-118 ◽  
Author(s):  
Celia Arroyo-López
Keyword(s):  
Helminth Therapy

Helminth Therapy – From the Parasite Perspective

2019 ◽  
Vol 35 (7) ◽  
pp. 501-515 ◽  
Author(s):  
Kateřina Sobotková ◽  
William Parker ◽  
Jana Levá ◽  
Jiřina Růžková ◽  
Julius Lukeš ◽  
...  
Keyword(s):  
Helminth Therapy

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

2014 ◽  
Vol 14 (11) ◽  
pp. 1150-1162 ◽  
Author(s):  
Linda J Wammes ◽  
Harriet Mpairwe ◽  
Alison M Elliott ◽  
Maria Yazdanbakhsh
Keyword(s):  
Clinical Considerations ◽  
Helminth Therapy

Helminth therapy for organic diseases?

2015 ◽  
Vol 166 (6) ◽  
pp. 586-601 ◽  
Author(s):  
Irina Leonardi ◽  
Isabelle Frey ◽  
Gerhard Rogler
Keyword(s):  
Helminth Therapy

2042 A Therapeutic Misadventure With Helminth Therapy for IBD

2019 ◽  
Vol 114 (1) ◽  
pp. S1144-S1144
Author(s):  
Lee Meluban ◽  
Mitchell K. Spinnell
Keyword(s):  
Helminth Therapy

scholarly journals Rapidly progressive respiratory failure after helminth larvae ingestion

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anahit A. Zeynalyan ◽  
Balaji Kolasani ◽  
Chetan Naik ◽  
Christopher J. G. Sigakis ◽  
Leann Silhan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Respiratory Failure ◽  
Right Heart Failure ◽  
Laboratory Evaluation ◽  
Heart Catheterization ◽  
Self Administration ◽  
High Resolution Computed Tomography ◽  
Right Heart ◽  
Progressive Respiratory Failure ◽  
Helminth Therapy

Abstract Background Self-administration of helminths has gained attention among patients as a potential but unproven therapy for autoimmune disease. We present a case of rapidly progressive respiratory failure in a patient with systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH) as a result of self-administration of parasitic organisms. Case A 45-year-old woman with a history of interstitial lung disease and PAH due to limited cutaneous SSc presented to pulmonary clinic with worsening dyspnea, cough, and new onset hypoxemia. Three months prior to presentation she started oral helminth therapy with Necator americanus as an alternative treatment for SSc. Laboratory evaluation revelaed eosinophilia and elevated IgE levels. IgG antibodies to Strongyloides were detected. High resolution computed tomography of the chest revealed progressive ILD and new diffuse ground glass opacities. Transthoracic echocardiogram and right heart catheterization illustrated worsening PAH and right heart failure. The patient was admitted to the hospital and emergently evaluated for lung transplantation but was not a candidate for transplantation due to comorbidities. Despite aggressive treatment for PAH and right heart failure, her respiratory status deteriorated, and the patient transitioned to comfort-focused care. Conclusion Although ingestion of helminths poses a risk of infection, helminth therapy has been investigated as a potential treatment for autoimmune diseases. In this case, self-prescribed helminth ingestion precipitated fatal acute worsening of lung inflammation, hypoxemia, and right heart dysfunction, highlighting the risk of experimental helminth therapy in patients, especially those with underlying respiratory disease.

scholarly journals Socio-Medical Studies of Individuals Self-Treating with Helminths Suggest That Most Clinical Trials Assessing Helminth Therapy May Be Designed to Fail

2020 ◽  
Author(s):  
Aarushi Venkatakrishnan ◽  
Joshua Hames ◽  
Kateřina Jirků-Pomajbíková ◽  
William Parker
Keyword(s):  
Clinical Trials ◽  
Immune Function ◽  
Therapeutic Efficacy ◽  
Complete Loss ◽  
Western Society ◽  
Medical Studies ◽  
Therapeutic Dosage ◽  
Mainstream Medicine ◽  
Intestinal Worms ◽  
Helminth Therapy

The virtually complete loss of intestinal worms, known as helminths, from Western society has resulted in elimination of a range of helminth-induced morbidities. Unfortunately, that loss has also led to inflammation-associated deficiencies in immune function, ultimately contributing to widespread pandemics of allergies, autoimmunity, and neuropsychiatric disorders. Several socio-medical studies have examined the effects of intentional reworming, or self-treatment with helminths, on a variety of inflammation-related disorders. In this study, the latest results from ongoing socio-medical studies are described. The results point toward two important factors that appear to be overlooked in some if not most clinical trials. Specifically, (a) the method of preparation of the helminth can have a profound effect on its therapeutic efficacy, and (b) variation between individuals in the effective therapeutic dosage apparently covers a 10-fold range, regardless of the helminth used. These results highlight current limits in our understanding of the biology of both hosts and helminths, and suggest that information from self-treatment may be critical in moving the field forward into mainstream medicine.

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