Adult-Born Neurons in the Olfactory Bulb: Integration and Functional Consequences

2012 ◽  
pp. 49-72 ◽  
Author(s):  
Gilles Gheusi ◽  
Gabriel Lepousez ◽  
Pierre-Marie Lledo
Keyword(s):  
Olfactory Bulb ◽  
Functional Consequences ◽  
Adult Born Neurons

scholarly journals Adult-born neurons facilitate olfactory bulb pattern separation during task engagement

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Wankun L Li ◽  
Monica W Chu ◽  
An Wu ◽  
Yusuke Suzuki ◽  
Itaru Imayoshi ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Adult Neurogenesis ◽  
Task Engagement ◽  
Pattern Separation ◽  
Inhibitory Neurons ◽  
Dependent Manner ◽  
Genetic Method ◽  
Two Photon ◽  
Passive Exposure ◽  
Adult Born Neurons

The rodent olfactory bulb incorporates thousands of newly generated inhibitory neurons daily throughout adulthood, but the role of adult neurogenesis in olfactory processing is not fully understood. Here we adopted a genetic method to inducibly suppress adult neurogenesis and investigated its effect on behavior and bulbar activity. Mice without young adult-born neurons (ABNs) showed normal ability in discriminating very different odorants but were impaired in fine discrimination. Furthermore, two-photon calcium imaging of mitral cells (MCs) revealed that the ensemble odor representations of similar odorants were more ambiguous in the ablation animals. This increased ambiguity was primarily due to a decrease in MC suppressive responses. Intriguingly, these deficits in MC encoding were only observed during task engagement but not passive exposure. Our results indicate that young olfactory ABNs are essential for the enhancement of MC pattern separation in a task engagement-dependent manner, potentially functioning as a gateway for top-down modulation.

scholarly journals GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits

2012 ◽  
Vol 32 (36) ◽  
pp. 12603-12611 ◽  
Author(s):  
W. Kelsch ◽  
Z. Li ◽  
M. Eliava ◽  
C. Goengrich ◽  
H. Monyer
Keyword(s):  
Olfactory Bulb ◽  
Nmda Receptors ◽  
Adult Born Neurons

scholarly journals Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit

2011 ◽  
Vol 1 (1) ◽  
pp. 6 ◽  
Author(s):  
Hiroyuki Katagiri ◽  
Marta Pallotto ◽  
Antoine Nissant ◽  
Kerren Murray ◽  
Marco Sassoè-Pognetto ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Dynamic Development ◽  
Adult Born Neurons

Regulation of survival and death of adult-born neurons in the local area of the olfactory bulb by local sensory input

2010 ◽  
Vol 68 ◽  
pp. e368
Author(s):  
Daisuke Mochimaru ◽  
Ko Kobayakawa ◽  
Reiko Kobayakawa ◽  
Hitoshi Sakano ◽  
Kensaku Mori ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Sensory Input ◽  
Local Area ◽  
Adult Born Neurons

scholarly journals The Role of Adult-Born Neurons in the Constantly Changing Olfactory Bulb Network

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sarah Malvaut ◽  
Armen Saghatelyan
Keyword(s):  
Olfactory Bulb ◽  
Synapse Formation ◽  
Daily Basis ◽  
Mammalian Brain ◽  
Neuronal Progenitors ◽  
Neuronal Precursors ◽  
Continuous Progress ◽  
Adult Born Neurons ◽  
Migratory Stream

The adult mammalian brain is remarkably plastic and constantly undergoes structurofunctional modifications in response to environmental stimuli. In many regions plasticity is manifested by modifications in the efficacy of existing synaptic connections or synapse formation and elimination. In a few regions, however, plasticity is brought by the addition of new neurons that integrate into established neuronal networks. This type of neuronal plasticity is particularly prominent in the olfactory bulb (OB) where thousands of neuronal progenitors are produced on a daily basis in the subventricular zone (SVZ) and migrate along the rostral migratory stream (RMS) towards the OB. In the OB, these neuronal precursors differentiate into local interneurons, mature, and functionally integrate into the bulbar network by establishing output synapses with principal neurons. Despite continuous progress, it is still not well understood how normal functioning of the OB is preserved in the constantly remodelling bulbar network and what role adult-born neurons play in odor behaviour. In this review we will discuss different levels of morphofunctional plasticity effected by adult-born neurons and their functional role in the adult OB and also highlight the possibility that different subpopulations of adult-born cells may fulfill distinct functions in the OB neuronal network and odor behaviour.

Postnatal Neurogenesis in the Olfactory Bulb

2016 ◽  
Author(s):  
Aleksandra Polosukhina ◽  
Pierre-Marie Lledo
Keyword(s):  
Olfactory Bulb ◽  
Granule Cells ◽  
Sensory Information ◽  
Adult Brain ◽  
Sensory Function ◽  
The Other ◽  
Forthcoming Article ◽  
Adult Born Neurons ◽  
Newborn Neurons ◽  
The Brain

This is an advance summary of a forthcoming article in the Oxford Research Encyclopedia of Neuroscience. Please check back later for the full article. In adult mammals, the olfactory bulb and the hippocampus are the regions in the brain that undergo continuous neurogenesis (production and recruitment of newborn neurons). While the other regions of the brain still retain a certain degree of plasticity after birth, they no longer can integrate new neurons. In rodents, thousands of adult-born neurons integrate into the bulb each day, and this process has been found to contribute not only to sensory function, but also to olfactory memory. This was a surprising finding, since historically the adult-brain has been viewed as a static organ. Understanding the process of regeneration of mature neurons in the brain has great potential for therapeutic applications. Consequently, this process of adult-neurogenesis has received widespread attention from clinicians and scientists. Neuroblasts bound for the olfactory bulb are produced in the subventricular zone of the lateral ventricle. Once they reach the olfactory bulb, they mostly develop into inhibitory interneurons called granule cells. Just after one month, about half of the adult-born neurons are eliminated, and the other half fully integrate and function in the olfactory bulb. These cells not only process information from the sensory neurons in the bulb, but also receive massive innervation from various regions of the brain, including the olfactory cortex, locus coeruleus, the horizontal limb of diagonal band of Broca, and the dorsal raphe nucleus. The sensory (bottom-up) and cortical (top-down) activity has been found to play a vital role in the adult-born granule cell survival. Though the exact purpose of these newborn neurons has not been identified, some emerging functions include maintenance of olfactory bulb circuitry, modulating sensory information, modulating olfactory learning, and memory.

scholarly journals Olfactory Discrimination Learning Increases the Survival of Adult-Born Neurons in the Olfactory Bulb

2006 ◽  
Vol 26 (41) ◽  
pp. 10508-10513 ◽  
Author(s):  
M. Alonso ◽  
C. Viollet ◽  
M.-M. Gabellec ◽  
V. Meas-Yedid ◽  
J.-C. Olivo-Marin ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Discrimination Learning ◽  
Olfactory Discrimination ◽  
Adult Born Neurons
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