scholarly journals Gene × Environment Interaction Models in Psychiatric Genetics

2011 ◽  
pp. 441-462 ◽  
Author(s):  
Katja Karg ◽  
Srijan Sen
Keyword(s):  
Environment Interaction ◽  
Psychiatric Genetics ◽  
Interaction Models ◽  
Gene Environment Interaction ◽  
Gene Environment

scholarly journals Encode and a new landscape for psychiatric genetics

2013 ◽  
Vol 203 (2) ◽  
pp. 84-85 ◽  
Author(s):  
Akshay Nair ◽  
Robert Howard
Keyword(s):  
Gene Regulation ◽  
Environment Interaction ◽  
Psychiatric Genetics ◽  
Encode Project ◽  
Polygenic Risk ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Rigorous Research ◽  
Dna Elements ◽  
Insight Into

SummaryDespite rigorous research into the genetics of neuropsychiatric disorders, the mechanism by which polygenic risk leads to complex clinical phenotypes remains unclear. The Encyclopedia of DNA Elements (ENCODE) project gives us new insight into gene regulation, and gene–gene and gene–environment interaction.Better understanding of these key genomic mechanisms may provide the answers we have been searching for.

Gene-Environment Interaction in the Determination of Levels of Haemostatic Variables Involved in Thrombosis and Fibrinolysis

1997 ◽  
Vol 78 (01) ◽  
pp. 457-461 ◽  
Author(s):  
S E Humphries ◽  
A Panahloo ◽  
H E Montgomery ◽  
F Green ◽  
J Yudkin
Keyword(s):  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment

Gene-environment Interaction on the Risk of Type 2 Diabetes Among Ethnic Minority Populations Living in Europe and North America: A Systematic Review

2020 ◽  
Vol 16 (5) ◽  
pp. 457-470 ◽  
Author(s):  
Mohammad H. Zafarmand ◽  
Parvin Tajik ◽  
René Spijker ◽  
Charles Agyemang
Keyword(s):  
Type 2 Diabetes ◽  
North America ◽  
Ethnic Minority ◽  
Ethnic Minorities ◽  
Minority Groups ◽  
Environment Interaction ◽  
Ethnic Minority Groups ◽  
Gene Environment Interaction ◽  
Gene Environment

Background: The body of evidence on gene-environment interaction (GEI) related to type 2 diabetes (T2D) has grown in the recent years. However, most studies on GEI have sought to explain variation within individuals of European ancestry and results among ethnic minority groups are inconclusive. Objective: To investigate any interaction between a gene and an environmental factor in relation to T2D among ethnic minority groups living in Europe and North America. Methods: We systematically searched Medline and EMBASE databases for the published literature in English up to 25th March 2019. The screening, data extraction and quality assessment were performed by reviewers independently. Results: 1068 studies identified through our search, of which nine cohorts of six studies evaluating several different GEIs were included. The mean follow-up time in the included studies ranged from 5 to 25.7 years. Most studies were relatively small scale and few provided replication data. All studies included in the review included ethnic minorities from North America (Native-Americans, African- Americans, and Aboriginal Canadian), none of the studies in Europe assessed GEI in relation to T2D incident in ethnic minorities. The only significant GEI among ethnic minorities was HNF1A rs137853240 and smoking on T2D incident among Native-Canadians (Pinteraction = 0.006). Conclusion: There is a need for more studies on GEI among ethnicities, broadening the spectrum of ethnic minority groups being investigated, performing more discovery using genome-wide approaches, larger sample sizes for these studies by collaborating efforts such as the InterConnect approach, and developing a more standardized method of reporting GEI studies are discussed.

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