Computer-Based Assessment of Alzheimer’s Disease Employing fMRI and/or EEG: A Comprehensive Review

2014 ◽  
pp. 351-383
Author(s):  
Evanthia E. Tripoliti ◽  
Michalis Zervakis ◽  
Dimitrios I. Fotiadis
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Comprehensive Review ◽  
Computer Based

Comprehensive review on Alzheimer's Disease: Pathophysiology and its Treatment

2021 ◽  
Vol 4 (3) ◽  
pp. 3-12
Author(s):  
Prativa Sadhu ◽  
◽  
Srijani Sen ◽  
Catherine Vanlalhriatpuii ◽  
◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Signs ◽  
Acetylcholinesterase Inhibitors ◽  
Neuron Activity ◽  
Aβ Peptides ◽  
Comprehensive Review ◽  
Thinking Ability ◽  
The Cost ◽  
Amyloid Cascade

Neurodegenerative disorders are marked by the loss of brain neuron activity, resulting in gradual cognitive impairment. The effects of neurodegenerative diseases are severe in terms of pathology and the cost of patient care. The aged, in general, are the most vulnerable. Alzheimer's disease (AD) is a brain ailment that causes cell degradation and is the leading cause of dementia, identified by a loss of thinking ability and independence in daily tasks. The amyloid cascade hypothesis, which attributes clinical signs/symptoms to an abundance of amyloid-beta (Aβ) peptides, enhanced deposition into amyloid plaques, and eventually neuronal destruction, is one theory for pathogenesis AD. The use of acetylcholinesterase inhibitors in AD treatment is based on their favorable effects on the disease's functional, cognitive and behavioral symptoms. However, their involvement in AD pathogenesis is uncertain. This comprehensive review will provide an overview of AD, including the pathophysiology, causes, treatments, and future treatment.

Using second life to teach health professions students about Alzheimer’s Disease: A comprehensive review

2022 ◽  
pp. 1-11
Author(s):  
Liliana Barros Una ◽  
Sharon Brangman ◽  
Alyssa Indelicato ◽  
Alice Krueger ◽  
Ann Ludwig ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Second Life ◽  
Health Professions ◽  
Comprehensive Review

Implementing Cognitive Exercises in Electronic Form for Supporting Patients with Alzheimer's Disease

2015 ◽  
pp. 130-146
Author(s):  
Agisilaos Chaldogeridis ◽  
Kleopatra Kyropoulou ◽  
Amaryllis-Chryssi Malegiannaki ◽  
Evdokia Nikolaidou ◽  
Thrasyvoulos Tsiatsos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intervention Programs ◽  
Electronic Form ◽  
Computer Based ◽  
Paper And Pencil

Main goal of this chapter is the development of computerized cognitive exercises for rehabilitation of patients with Alzheimer's disease. More specifically, in traditional rehabilitation settings cognitive exercises are administered by using the paper-and-pencil procedure. This chapter is focused on the transferring of these interventions to an electronic form, enriched with multimedia and interactions that cannot be achieved in the printed form. The presented work tries to automate the procedure and facilitate the psychologist's work. Computer-based intervention programs can exploit all the possibilities of adjusting the difficulty levels of exercise, the speed, the images, using audible signals, accelerating the processing of results for psychologists and much more that add value to creation of such programs. This chapter explores whether and how this kind of exercises can be successfully transferred in an electronic form.

scholarly journals Vascular Contribution to Cognition in Stroke and Alzheimer's Disease

2018 ◽  
Vol 4 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Yuanhan Yang ◽  
Jongling Fuh ◽  
Vincent C. T. Mok
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Degenerative Diseases ◽  
Comprehensive Review ◽  
Risks Factors ◽  
Vascular Contribution

Vascular factors to cognitive impairment in degenerative on non-degenerative diseases have been reported, examined, and debated for several decades. The various definitions of cognitive impairment due to vascular origins will make these results diverse. During this review, we are going to report currently update information of vascular contributions to cognitive function, in clinical or neuroimaging findings. Risks factors and their managements also will be discussed and reported to have a comprehensive review.

scholarly journals Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease

2021 ◽  
Vol 22 (24) ◽  
pp. 13618
Author(s):  
Lernik Hunanyan ◽  
Viktor Ghamaryan ◽  
Ani Makichyan ◽  
Elena Popugaeva
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
Dendritic Spines ◽  
Structural Features ◽  
Fine Tuning ◽  
3D Structures ◽  
Drug Candidates ◽  
Store Operated Calcium Entry ◽  
Computer Based

Store-operated calcium entry (SOCE) constitutes a fine-tuning mechanism responsible for the replenishment of intracellular stores. Hippocampal SOCE is regulated by store-operated channels (SOC) organized in tripartite complex TRPC6/ORAI2/STIM2. It is suggested that in neurons, SOCE maintains intracellular homeostatic Ca2+ concentration at resting conditions and is needed to support the structure of dendritic spines. Recent evidence suggests that positive modulators of SOC are prospective drug candidates to treat Alzheimer’s disease (AD) at early stages. Although STIM2 and ORAI2 are definitely involved in the regulation of nSOC amplitude and a play major role in AD pathogenesis, growing evidence suggest that it is not easy to target these proteins pharmacologically. Existing positive modulators of TRPC6 are unsuitable for drug development due to either bad pharmacokinetics or side effects. Thus, we concentrate the review on perspectives to develop specific nSOC modulators based on available 3D structures of TRPC6, ORAI2, and STIM2. We shortly describe the structural features of existing models and the methods used to prepare them. We provide commonly used steps applied for drug design based on 3D structures of target proteins that might be used to develop novel AD preventing therapy.

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