Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints

2012 ◽  
pp. 21-36 ◽  
Author(s):  
José M. Orellana-Muriana
Keyword(s):  
Cancer Research ◽  
Animal Models ◽  
Research Assessment

scholarly journals New insights on CRISPR/Cas9-based therapy for breast Cancer

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Hussein Sabit ◽  
Shaimaa Abdel-Ghany ◽  
Huseyin Tombuloglu ◽  
Emre Cevik ◽  
Amany Alqosaibi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Animal Models ◽  
Human Cancer ◽  
Step Process ◽  
Cancer Initiation ◽  
Malignant State ◽  
Treat Breast Cancer

AbstractCRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result in the hallmark of the malignant state. The goal of cancer research is to identify these mutations and correlate them with the underlying tumorigenic process. Using CRISPR/Cas9 tool, specific mutations responsible for cancer initiation and/or progression could be corrected at least in animal models as a first step towards translational applications. In the present article, we review various novel strategies that employed CRISPR/Cas9 to treat breast cancer in both in vitro and in vivo systems.

scholarly journals Spontaneous and Induced Animal Models for Cancer Research

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 660
Author(s):  
Anca Onaciu ◽  
Raluca Munteanu ◽  
Vlad Cristian Munteanu ◽  
Diana Gulei ◽  
Lajos Raduly ◽  
...  
Keyword(s):  
Cancer Research ◽  
Animal Models ◽  
Mouse Models ◽  
Behavioral Science ◽  
Laboratory Mouse ◽  
Human Tumor ◽  
Large Animal ◽  
Large Animal Models ◽  
Oncology Research ◽  
Genetically Engineered Mice

Considering the complexity of the current framework in oncology, the relevance of animal models in biomedical research is critical in light of the capacity to produce valuable data with clinical translation. The laboratory mouse is the most common animal model used in cancer research due to its high adaptation to different environments, genetic variability, and physiological similarities with humans. Beginning with spontaneous mutations arising in mice colonies that allow for pursuing studies of specific pathological conditions, this area of in vivo research has significantly evolved, now capable of generating humanized mice models encompassing the human immune system in biological correlation with human tumor xenografts. Moreover, the era of genetic engineering, especially of the hijacking CRISPR/Cas9 technique, offers powerful tools in designing and developing various mouse strains. Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar mouse models for personalized cancer therapy. Moreover, the area of spontaneous large animal models for cancer research will be briefly presented.

scholarly journals Translational Animal Models for Liver Cancer

2018 ◽  
Vol 2 ◽  
pp. 2 ◽  
Author(s):  
Michele Obeid ◽  
Ramzy C. Khabbaz ◽  
Kelly D. Garcia ◽  
Kyle M. Schachtschneider ◽  
Ron C. Gaba
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Research ◽  
Animal Models ◽  
Liver Cancer ◽  
Small Animal ◽  
Large Animal ◽  
Starting Point ◽  
Perfect Model ◽  
Small Animal Models ◽  
Human Primate

Animal models have become increasingly important in the study of hepatocellular carcinoma (HCC), as they serve as a critical bridge between laboratory-based discoveries and human clinical trials. Developing an ideal animal model for translational use is challenging, as the perfect model must be able to reproduce human disease genetically, anatomically, physiologically, and pathologically. This brief review provides an overview of the animal models currently available for translational liver cancer research, including rodent, rabbit, non-human primate, and pig models, with a focus on their respective benefits and shortcomings. While small animal models offer a solid starting point for investigation, large animal HCC models are becoming increasingly important for translation of preclinical results to clinical practice.

Animal models in oral cancer research

Oral Oncology ◽  
2006 ◽  
Vol 42 (5) ◽  
pp. 448-460 ◽  
Author(s):  
B. Mognetti ◽  
F. Di Carlo ◽  
G.N. Berta
Keyword(s):  
Cancer Research ◽  
Oral Cancer ◽  
Animal Models

Utility of Animal Models in Pancreatic Cancer Research

2008 ◽  
pp. 577-599 ◽  
Author(s):  
Asfar S. Azmi ◽  
Mussop Mohammad ◽  
Ahmed O. Kaseb ◽  
Fazlul H. Sarkar ◽  
Ramzi M. Mohammad
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Research ◽  
Animal Models

scholarly journals Animal Models for Radiolabeled Monoclonal Antibodies in Cancer Research

1993 ◽  
Vol 32 (7-8) ◽  
pp. 819-824 ◽  
Author(s):  
Magne Aas ◽  
Jan G. Fjeld
Keyword(s):  
Cancer Research ◽  
Monoclonal Antibodies ◽  
Animal Models

scholarly journals Advances in colon cancer research: in vitro and animal models

2021 ◽  
Vol 66 ◽  
pp. 50-56
Author(s):  
Tamsin RM Lannagan ◽  
Rene Jackstadt ◽  
Simon J Leedham ◽  
Owen J Sansom
Keyword(s):  
Colon Cancer ◽  
Cancer Research ◽  
Animal Models
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