Investigating Sleep Homeostasis with Extracellular Recording of Multiunit Activity from the Neocortex in Freely Behaving Rats

2011 ◽  
pp. 237-258 ◽  
Author(s):  
Vladyslav V. Vyazovskiy ◽  
Umberto Olcese ◽  
Giulio Tononi
Keyword(s):  
Extracellular Recording ◽  
Multiunit Activity ◽  
Sleep Homeostasis ◽  
Freely Behaving

scholarly journals Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Christopher W Thomas ◽  
Mathilde CC Guillaumin ◽  
Laura E McKillop ◽  
Peter Achermann ◽  
Vladyslav V Vyazovskiy
Keyword(s):  
Neuronal Activity ◽  
Wave Activity ◽  
Neuronal Firing ◽  
Daily Amount ◽  
Local Process ◽  
Sleep Homeostasis ◽  
Freely Behaving ◽  
Electroencephalogram Eeg ◽  
Activity Dependent ◽  
Wake State

Sleep homeostasis manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions define ‘Process S’, a variable with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG) slow wave activity (SWA, 0.5–4 Hz) during sleep. The notion of sleep as a local, activity-dependent process suggests that activity history must be integrated to determine the dynamics of global Process S. Here, we developed novel mathematical models of Process S based on cortical activity recorded in freely behaving mice, describing local Process S as a function of the deviation of neuronal firing rates from a locally defined set-point, independent of global sleep-wake state. Averaging locally derived Processes S and their rate parameters yielded values resembling those obtained from EEG SWA and global vigilance states. We conclude that local Process S dynamics reflects neuronal activity integrated over time, and global Process S reflects local processes integrated over space.

Melatonin modifies the spontaneous multiunit activity recorded in several brain nuclei of freely behaving rats

1991 ◽  
Vol 27 (5) ◽  
pp. 595-600 ◽  
Author(s):  
E.B. Naranjo-Rodríguez ◽  
B. Prieto-Gómez ◽  
C. Reyes-Vázquez
Keyword(s):  
Brain Nuclei ◽  
Multiunit Activity ◽  
Freely Behaving

scholarly journals Cortical zeta-inhibitory peptide injection reduces local sleep need

SLEEP ◽  
2019 ◽  
Vol 42 (5) ◽  
Author(s):  
Caitlin M Carroll ◽  
Harrison Hsiang ◽  
Sam Snyder ◽  
Jade Forsberg ◽  
Michael B Dash
Keyword(s):  
Motor Cortex ◽  
Synaptic Strength ◽  
Saline Control ◽  
Inhibitory Peptide ◽  
Local Reduction ◽  
Sleep Homeostasis ◽  
Freely Behaving ◽  
Protein Kinase Mζ ◽  
The Right ◽  
Local Sleep

Abstract Local sleep need within cortical circuits exhibits extensive interregional variability and appears to increase following learning during preceding waking. Although the biological mechanisms responsible for generating sleep need are unclear, this local variability could arise as a consequence of wake-dependent synaptic plasticity. To test whether cortical synaptic strength is a proximate driver of sleep homeostasis, we developed a novel experimental approach to alter local sleep need. One hour prior to light onset, we injected zeta-inhibitory peptide (ZIP), a pharmacological antagonist of protein kinase Mζ, which can produce pronounced synaptic depotentiation, into the right motor cortex of freely behaving rats. When compared with saline control, ZIP selectively reduced slow-wave activity (SWA; the best electrophysiological marker of sleep need) within the injected motor cortex without affecting SWA in a distal cortical site. This local reduction in SWA was associated with a significant reduction in the slope and amplitude of individual slow waves. Local ZIP injection did not significantly alter the amount of time spent in each behavioral state, locomotor activity, or EEG/LFP power during waking or REM sleep. Thus, local ZIP injection selectively produced a local reduction in sleep need; synaptic strength, therefore, may play a causal role in generating local homeostatic sleep need within the cortex.

Homeostatic Response to Sleep Restriction in Adolescents

SLEEP ◽  
2021 ◽  
Author(s):  
Jelena Skorucak ◽  
Nathan Weber ◽  
Mary A Carskadon ◽  
Chelsea Reynolds ◽  
Scott Coussens ◽  
...  
Keyword(s):  
Slow Wave ◽  
Process Model ◽  
Animal Studies ◽  
Sleep Restriction ◽  
Sleep Regulation ◽  
Homeostatic Process ◽  
Sleep Homeostasis ◽  
High Prevalence ◽  
Homeostatic Response ◽  
Chronic Sleep

Abstract The high prevalence of chronic sleep restriction in adolescents underscores the importance of understanding how adolescent sleep is regulated under such conditions. One component of sleep regulation is a homeostatic process: if sleep is restricted, then sleep intensity increases. Our knowledge of this process is primarily informed by total sleep deprivation studies and has been incorporated in mathematical models of human sleep regulation. Several animal studies, however, suggest that adaptation occurs in chronic sleep restriction conditions, showing an attenuated or even decreased homeostatic response. We investigated the homeostatic response of adolescents to different sleep opportunities. Thirty-four participants were allocated to one of three groups with 5, 7.5 or 10 h of sleep opportunity per night for 5 nights. Each group underwent a protocol of 9 nights designed to mimic a school week between 2 weekends: 2 baseline nights (10 h sleep opportunity), 5 condition nights (5, 7.5 or 10 h), and two recovery nights (10 h). Measures of sleep homeostasis (slow-wave activity and slow-wave energy) were calculated from frontal and central EEG derivations and compared to predictions derived from simulations of the homeostatic process of the two-process model of sleep regulation. Only minor differences were found between empirical data and model predictions, indicating that sleep homeostasis is preserved under chronic sleep restriction in adolescents. These findings improve our understanding of effects of repetitive short sleep in adolescents.

Simulation of sleep in a mouse: quantitative analysis of the region-specific and wake behaviour-dependent dynamics of sleep homeostasis

2017 ◽  
Vol 40 ◽  
pp. e120-e121
Author(s):  
M.C.C. Guillaumin ◽  
L.E. McKillop ◽  
N. Cui ◽  
S.P. Fisher ◽  
M. de Vos ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Sleep Homeostasis
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