Inhibitors of Histidinol Dehydrogenase

2016 ◽  
pp. 35-46
Author(s):  
Stephan Köhler ◽  
Jean Dessolin ◽  
Jean-Yves Winum
Keyword(s):  
Histidinol Dehydrogenase

scholarly journals Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

2008 ◽  
Vol 23 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Marie-Rose Abdo ◽  
Pascale Joseph ◽  
Rose-Anne Boigegrain ◽  
Jean-Louis Montero ◽  
Stephan Köhler ◽  
...  
Keyword(s):  
Brucella Suis ◽  
Histidinol Dehydrogenase ◽  
Inhibition Studies

scholarly journals Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase

2002 ◽  
Vol 99 (4) ◽  
pp. 1859-1864 ◽  
Author(s):  
J. A. R. G. Barbosa ◽  
J. Sivaraman ◽  
Y. Li ◽  
R. Larocque ◽  
A. Matte ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Mechanism Of Action ◽  
Binding Mode ◽  
Histidinol Dehydrogenase

scholarly journals Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph.

1990 ◽  
Vol 172 (7) ◽  
pp. 3898-3904 ◽  
Author(s):  
Z Altboum ◽  
S Gottlieb ◽  
G A Lebens ◽  
I Polacheck ◽  
E Segal
Keyword(s):  
Candida Albicans ◽  
Histidinol Dehydrogenase ◽  
His4 Gene ◽  
Histidine Auxotroph

113Cd Nuclear Magnetic Resonance Studies of Cabbage Histidinol Dehydrogenase

Biochemistry ◽  
1996 ◽  
Vol 35 (19) ◽  
pp. 5949-5954 ◽  
Author(s):  
Kenji Kanaori ◽  
Nobuko Uodome ◽  
Atsuko Nagai ◽  
Daisaku Ohta ◽  
Atsuko Ogawa ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Studies ◽  
Histidinol Dehydrogenase ◽  
Nuclear Magnetic

Determination by1H-NMR of the Stereospecificity of NAD-dependent PlantL-Histidinol Dehydrogenase for Nicotinamide C-4 Hydrogen Transfer

1995 ◽  
Vol 59 (7) ◽  
pp. 1370-1371
Author(s):  
Atsuko Nagai ◽  
Hiroko Shimoi-Nishiyama ◽  
Daisaku Ohta ◽  
Alfred Scheidegger ◽  
Nobuyoshi Esaki ◽  
...  
Keyword(s):  
Hydrogen Transfer ◽  
Histidinol Dehydrogenase

scholarly journals C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae.

1992 ◽  
Vol 12 (1) ◽  
pp. 276-282 ◽  
Author(s):  
N Green ◽  
P Walter
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Endoplasmic Reticulum ◽  
Fusion Proteins ◽  
Signal Sequence ◽  
Dna Encoding ◽  
Luminal Side ◽  
Internal Signal ◽  
Histidinol Dehydrogenase ◽  
Arginine Permease ◽  
Er Membrane

We have constructed three gene fusions that encode portions of a membrane protein, arginine permease, fused to a reporter domain, the cytoplasmic enzyme histidinol dehydrogenase (HD), located at the C-terminal end. These fusion proteins contain at least one of the internal signal sequences of arginine permease. When the fusion proteins were expressed in Saccharomyces cerevisiae and inserted into the endoplasmic reticulum (ER), two of the fusion proteins placed HD on the luminal side of the ER membrane, but only when a piece of DNA encoding a spacer protein segment was inserted into the fusion joint. The third fusion protein, with or without the spacer included, placed HD on the cytoplasmic side of the membrane. These results suggest that (i) sequences C-terminal to the internal signal sequence can inhibit membrane insertion and (ii) HD requires a preceding spacer segment to be translocated across the ER membrane.

Crystallization and preliminary crystallographic analysis of cabbage histidinol dehydrogenase

1996 ◽  
Vol 52 (6) ◽  
pp. 1188-1190 ◽  
Author(s):  
S. W. Cowan-Jacob ◽  
J. Rahuel ◽  
A. Nagai ◽  
G. Iwasaki ◽  
D. Ohta
Keyword(s):  
Crystallographic Analysis ◽  
Histidinol Dehydrogenase
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