Arsenic Metabolism in Prokaryotic and Eukaryotic Microbes

2007 ◽  
pp. 371-406 ◽  
Author(s):  
Hiranmoy Bhattacharjee ◽  
Barry P. Rosen
Keyword(s):  
Arsenic Metabolism ◽  
Eukaryotic Microbes

Physical activity, body mass index and arsenic metabolism among Mexican women

2021 ◽  
Vol 195 ◽  
pp. 110869
Author(s):  
Brenda Gamboa-Loira ◽  
Mariano E. Cebrián ◽  
Lizbeth López-Carrillo
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Mexican Women ◽  
Arsenic Metabolism

scholarly journals Mendelian randomization analysis of arsenic metabolism and pulmonary function within the Hispanic Community Health Study/Study of Latinos

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Molly Scannell Bryan ◽  
Tamar Sofer ◽  
Majid Afshar ◽  
Yasmin Mossavar-Rahmani ◽  
H. Dean Hosgood ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Mendelian Randomization ◽  
Smoking History ◽  
Health Study ◽  
Arsenic Metabolism ◽  
Percentage Point Increase ◽  
Point Increase ◽  
Increased Risk ◽  
Genotype Information ◽  
Rice Consumption

AbstractArsenic exposure has been linked to poor pulmonary function, and inefficient arsenic metabolizers may be at increased risk. Dietary rice has recently been identified as a possible substantial route of exposure to arsenic, and it remains unknown whether it can provide a sufficient level of exposure to affect pulmonary function in inefficient metabolizers. Within 12,609 participants of HCHS/SOL, asthma diagnoses and spirometry-based measures of pulmonary function were assessed, and rice consumption was inferred from grain intake via a food frequency questionnaire. After stratifying by smoking history, the relationship between arsenic metabolism efficiency [percentages of inorganic arsenic (%iAs), monomethylarsenate (%MMA), and dimethylarsinate (%DMA) species in urine] and the measures of pulmonary function were estimated in a two-sample Mendelian randomization approach (genotype information from an Illumina HumanOmni2.5-8v1-1 array), focusing on participants with high inferred rice consumption. Among never-smoking high inferred consumers of rice (n = 1395), inefficient metabolism was associated with past asthma diagnosis and forced vital capacity below the lower limit of normal (LLN) (OR 1.40, p = 0.0212 and OR 1.42, p = 0.0072, respectively, for each percentage-point increase in %iAs; OR 1.26, p = 0.0240 and OR 1.24, p = 0.0193 for %MMA; OR 0.87, p = 0.0209 and OR 0.87, p = 0.0123 for the marker of efficient metabolism, %DMA). Among ever-smoking high inferred consumers of rice (n = 1127), inefficient metabolism was associated with peak expiratory flow below LLN (OR 1.54, p = 0.0108/percentage-point increase in %iAs, OR 1.37, p = 0.0097 for %MMA, and OR 0.83, p = 0.0093 for %DMA). Less efficient arsenic metabolism was associated with indicators of pulmonary dysfunction among those with high inferred rice consumption, suggesting that reductions in dietary arsenic could improve respiratory health.

scholarly journals Factors Affecting Arsenic Methylation in Contaminated Italian Areas

2020 ◽  
Vol 17 (14) ◽  
pp. 5226
Author(s):  
Elisa Bustaffa ◽  
Francesca Gorini ◽  
Fabrizio Bianchi ◽  
Fabrizio Minichilli
Keyword(s):  
Dietary Habits ◽  
Public Health Issue ◽  
Contaminated Water ◽  
Metabolic Capacity ◽  
Genetic Characteristics ◽  
Arsenic Metabolism ◽  
Factors Affecting ◽  
Arsenic Methylation ◽  
Methylation Capacity ◽  
Critical Public Health

Chronic arsenic (As) exposure is a critical public health issue. The As metabolism can be influenced by many factors. The objective of this study is to verify if these factors influence As metabolism in four Italian areas affected by As pollution. Descriptive analyses were conducted on 271 subjects aged 20–49 in order to assess the effect of each factor considered on As methylation. Percentages of metabolites of As in urine, primary and secondary methylation indexes were calculated as indicators for metabolic capacity. The results indicate that women have a better methylation capacity (MC) than men, and drinking As-contaminated water from public aqueducts is associated with poorer MC, especially in areas with natural As pollution. In areas with anthropogenic As pollution occupational exposure is associated with a higher MC while smoking with a poorer MC. Dietary habits and genetic characteristics are probably implicated in As metabolism. BMI, alcohol consumption and polymorphism of the AS3MT gene seem not to influence As MC. Arsenic metabolism may be affected by various factors and in order to achieve a comprehensive risk assessment of As-associated disease, it is crucial to understand how these factors contribute to differences in As metabolism.

scholarly journals Dynamics and Innovations within Oomycete Genomes: Insights into Biology, Pathology, and Evolution

2012 ◽  
Vol 11 (11) ◽  
pp. 1304-1312 ◽  
Author(s):  
Howard S. Judelson
Keyword(s):  
Protein Sequence ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Life Cycles ◽  
Aquatic Environments ◽  
Gene Fusions ◽  
Additional Species ◽  
Functional Studies ◽  
Eukaryotic Microbes ◽  
Genome Projects

ABSTRACT The eukaryotic microbes known as oomycetes are common inhabitants of terrestrial and aquatic environments and include saprophytes and pathogens. Lifestyles of the pathogens extend from biotrophy to necrotrophy, obligate to facultative pathogenesis, and narrow to broad host ranges on plants or animals. Sequencing of several pathogens has revealed striking variation in genome size and content, a plastic set of genes related to pathogenesis, and adaptations associated with obligate biotrophy. Features of genome evolution include repeat-driven expansions, deletions, gene fusions, and horizontal gene transfer in a landscape organized into gene-dense and gene-sparse sectors and influenced by transposable elements. Gene expression profiles are also highly dynamic throughout oomycete life cycles, with transcriptional polymorphisms as well as differences in protein sequence contributing to variation. The genome projects have set the foundation for functional studies and should spur the sequencing of additional species, including more diverse pathogens and nonpathogens.

scholarly journals A pilot study: The importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome

2013 ◽  
Vol 36 (3) ◽  
pp. 1266-1275 ◽  
Author(s):  
Elyssa R. Gelmann ◽  
Eugen Gurzau ◽  
Anca Gurzau ◽  
Walter Goessler ◽  
Julie Kunrath ◽  
...  
Keyword(s):  
Individual Differences ◽  
Birth Weight ◽  
Pilot Study ◽  
Inorganic Arsenic ◽  
Arsenic Metabolism
Sign in / Sign up

Export Citation Format

Share Document