Aminolactam, N-Aminoimidazolone, and N-Aminoimdazolidinone Peptide Mimics

2017 ◽  
pp. 125-175 ◽  
Author(s):  
Daniel J. St-Cyr ◽  
Yésica García-Ramos ◽  
Ngoc-Duc Doan ◽  
William D. Lubell
Keyword(s):  
Peptide Mimics

scholarly journals Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial in vitro

Glycobiology ◽  
2016 ◽  
Vol 26 (5) ◽  
pp. 540-540 ◽  
Author(s):  
Robert K Yu ◽  
Seigo Usuki ◽  
Yutaka Itokazu ◽  
Han-Chung Wu
Keyword(s):  
Cholera Toxin ◽  
Gm1 Ganglioside ◽  
Intestinal Epithelial ◽  
Peptide Mimics

Synthesis of dendrimeric N-glyoxylamide peptide mimics

2011 ◽  
Vol 52 (28) ◽  
pp. 3645-3647 ◽  
Author(s):  
Thanh Le ◽  
Wai Ching Cheah ◽  
Kasey Wood ◽  
David St.C. Black ◽  
Mark D. Willcox ◽  
...  
Keyword(s):  
Peptide Mimics

scholarly journals Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Brian Hall ◽  
Carley Squires ◽  
Keith K. Parker
Keyword(s):  
G Protein ◽  
Pharmacological Intervention ◽  
Intracellular Camp ◽  
Intracellular Loop ◽  
Peptide Mimics ◽  
G Protein Coupling ◽  
5Ht1a Receptor ◽  
Protein Coupling ◽  
Loop Region ◽  
Loop 2

Peptide mimics of intracellular loop 2 (ic2) of the human 5HT1a receptor have been studied with respect to their ability to inhibit agonist binding via interference with receptor-G-protein coupling. These peptides give shallow concentration-effect relationships. Additionally, these peptides have been studied with respect to their ability to trigger the signal transduction system of this Gi-coupled receptor. Two signaling parameters have been quantified: concentration of intracellular cAMP and changes in incorporation into the G protein of a stable analog of GTP. In both cases, peptide mimics near midloop of ic2 actually show agonist activity with efficacy falling off toward both loop termini near TM 3 and TM 4. Previous results have suggested that the loop region near the TM3/ic2 interface is primarily responsible for receptor-G-protein coupling, while the current result emphasizes the mid-ic2 loop region's ability to activate the G protein following initial coupling. A limited number of peptides from the receptor's TM5/ic3 loop vicinity were also studied regarding agonist inhibition and G-protein activation. These peptides provide additional evidence that the human 5HT1a receptor, TM5/ic3 loop region, is involved in both coupling and activation actions. Overall, these results provide further information about potential pharmacological intervention and drug development with respect to the human 5HT1a receptor/G-protein system. Finally, the structural evidence generated here provides testable models pending crystallization and X-ray analysis of the receptor.

scholarly journals A Small Cyclic β‐Hairpin Peptide Mimics the Rbfox2 RNA Recognition Motif and Binds to the Precursor miRNA 20b

ChemBioChem ◽  
2019 ◽  
Vol 20 (7) ◽  
pp. 931-939 ◽  
Author(s):  
Yi‐Ting Sun ◽  
Matthew D. Shortridge ◽  
Gabriele Varani
Keyword(s):  
Rna Recognition Motif ◽  
Rna Recognition ◽  
Peptide Mimics ◽  
Recognition Motif

Synthesis of methyl 3-amino-2-hydroxy-4-phenylbutanoates, important core intermediates for peptide mimics possessing biological activities

2001 ◽  
Vol 42 (11) ◽  
pp. 2145-2147 ◽  
Author(s):  
Hisao Nemoto ◽  
Rujian Ma ◽  
Xinming Li ◽  
Ichiro Suzuki ◽  
Masayuki Shibuya
Keyword(s):  
Biological Activities ◽  
Peptide Mimics

Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics

ACS Catalysis ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 8276-8284 ◽  
Author(s):  
Zheliang Yuan ◽  
Hua Yang ◽  
Noeen Malik ◽  
Milena Čolović ◽  
David S. Weber ◽  
...  
Keyword(s):  
Small Molecules ◽  
Electrostatic Effects ◽  
Peptide Mimics
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