Recent Advances in the Generation of β-Cells from Induced Pluripotent Stem Cells as a Potential Cure for Diabetes Mellitus

2021 ◽  
pp. 1-27
Author(s):  
Akriti Agrawal ◽  
Gloria Narayan ◽  
Ranadeep Gogoi ◽  
Rajkumar P. Thummer
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Β Cells ◽  
Recent Advances ◽  
Induced Pluripotent

scholarly journals Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells

2016 ◽  
Vol 17 (2) ◽  
pp. 256 ◽  
Author(s):  
Mohammed Kawser Hossain ◽  
Ahmed Abdal Dayem ◽  
Jihae Han ◽  
Subbroto Kumar Saha ◽  
Gwang-Mo Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Drug Discovery ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
Recent Advances ◽  
Induced Pluripotent

Advances in the Generation of Functional β-cells from Induced Pluripotent Stem Cells As a Cure for Diabetes Mellitus

2018 ◽  
Vol 19 (13) ◽  
pp. 1463-1477 ◽  
Author(s):  
Kunal Kalra ◽  
Srijaya Thekkeparambil Chandrabose ◽  
Thamil Selvee Ramasamy ◽  
Noor Hayaty Binti Abu Kasim
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Β Cells ◽  
Induced Pluripotent

scholarly journals Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2465
Author(s):  
Sevda Gheibi ◽  
Tania Singh ◽  
Joao Paulo M. C. M. da Cunha ◽  
Malin Fex ◽  
Hindrik Mulder
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
Research Area ◽  
New Drugs ◽  
Β Cells ◽  
Treatment Of Diabetes ◽  
Induced Pluripotent

Type 2 diabetes, characterized by dysfunction of pancreatic β-cells and insulin resistance in peripheral organs, accounts for more than 90% of all diabetes. Despite current developments of new drugs and strategies to prevent/treat diabetes, there is no ideal therapy targeting all aspects of the disease. Restoration, however, of insulin-producing β-cells, as well as insulin-responsive cells, would be a logical strategy for the treatment of diabetes. In recent years, generation of transplantable cells derived from stem cells in vitro has emerged as an important research area. Pluripotent stem cells, either embryonic or induced, are alternative and feasible sources of insulin-secreting and glucose-responsive cells. This notwithstanding, consistent generation of robust glucose/insulin-responsive cells remains challenging. In this review, we describe basic concepts of the generation of induced pluripotent stem cells and subsequent differentiation of these into pancreatic β-like cells, myotubes, as well as adipocyte- and hepatocyte-like cells. Use of these for modeling of human disease is now feasible, while development of replacement therapies requires continued efforts.

Recent Advances in Therapeutic Applications of Induced Pluripotent Stem Cells

2017 ◽  
Vol 19 (2) ◽  
pp. 65-74 ◽  
Author(s):  
Farzaneh Rami ◽  
Shamsi Naderi Beni ◽  
Mahboobeh Mojaver Kahnamooi ◽  
Ilnaz Rahimmanesh ◽  
Ahmad Reza Salehi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Therapeutic Applications ◽  
Recent Advances ◽  
Induced Pluripotent

scholarly journals Inducing pluripotencyin vitro: recent advances and highlights in induced pluripotent stem cells generation and pluripotency reprogramming

2015 ◽  
Vol 48 (2) ◽  
pp. 140-156 ◽  
Author(s):  
I. K. Rony ◽  
A. Baten ◽  
J. A Bloomfield ◽  
M. E. Islam ◽  
M. M. Billah ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Recent Advances ◽  
Induced Pluripotent

Efficient generation of functional pancreatic β-cells from human induced pluripotent stem cells

2016 ◽  
Vol 9 (2) ◽  
pp. 168-179 ◽  
Author(s):  
Shigeharu G. Yabe ◽  
Satsuki Fukuda ◽  
Fujie Takeda ◽  
Kiyoko Nashiro ◽  
Masayuki Shimoda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Efficient Generation ◽  
Induced Pluripotent
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