The Cellular and Molecular Patterns Involved in the Neural Differentiation of Adipose-Derived Stem Cells

2020 ◽  
pp. 23-41
Author(s):  
Aida Selaru ◽  
Sorina Dinescu ◽  
Marieta Costache
Keyword(s):  
Stem Cells ◽  
Neural Differentiation ◽  
Adipose Derived Stem Cells ◽  
Molecular Patterns

Neural Differentiation of Rat Adipose-Derived Stem Cells in Vitro

2012 ◽  
Vol 32 (8) ◽  
pp. 1255-1263 ◽  
Author(s):  
Chengcheng Ying ◽  
Wanli Hu ◽  
Bei Cheng ◽  
Xinmin Zheng ◽  
Shiwen Li
Keyword(s):  
Stem Cells ◽  
Neural Differentiation ◽  
Adipose Derived Stem Cells

An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells

2015 ◽  
Vol 12 (1) ◽  
pp. 26-41 ◽  
Author(s):  
Hossein Salehi ◽  
Noushin Amirpour ◽  
Ali Niapour ◽  
Shahnaz Razavi
Keyword(s):  
Stem Cells ◽  
Neural Differentiation ◽  
Adipose Derived Stem Cells ◽  
Differentiation Potential

Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice

2005 ◽  
Vol 333 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Juri Fujimura ◽  
Rei Ogawa ◽  
Hiroshi Mizuno ◽  
Yoshitaka Fukunaga ◽  
Hidenori Suzuki
Keyword(s):  
Stem Cells ◽  
Transgenic Mice ◽  
Neural Differentiation ◽  
Adipose Derived Stem Cells

Effect of T3hormone on neural differentiation of human adipose derived stem cells

2014 ◽  
Vol 32 (8) ◽  
pp. 702-710 ◽  
Author(s):  
Shahnaz Razavi ◽  
Fatemeh Sadat Mostafavi ◽  
Mohammad Mardani ◽  
Hamid Zarkesh Esfahani ◽  
Mohammad Kazemi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Differentiation ◽  
Adipose Derived Stem Cells

scholarly journals Synergistic effects of conductivity and cell-imprinted topography of chitosan-polyaniline based scaffolds for neural differentiation of adipose-derived stem cells

2020 ◽  
Author(s):  
Behnaz Sadat Eftekhari ◽  
Mahnaz Eskandari ◽  
Paul Janmey ◽  
Ali Samadikuchaksaraei ◽  
Mazaher Gholipurmalekabadi
Keyword(s):  
Stem Cells ◽  
Neural Differentiation ◽  
Cultured Cells ◽  
Synergistic Effects ◽  
Young Modulus ◽  
Adipose Derived Stem Cells ◽  
Differentiation Markers ◽  
A Cell ◽  
Cell Niche ◽  
Altered Gene

AbstractSmart nano-environments that mimic the stem cell niche can guide cell behavior to support functional repair and regeneration of tissues. The specific microenvironment of nervous tissue is composed of several physical signaling factors, including proper topography, flexibility, and electric conductance. In this study, a cell-imprinting technique was used to obtain a hierarchical topographical conductive scaffold based on chitosan-polyaniline (PANI) hydrogels for directing the neural differentiation of rat adipose-derived stem cells (rADSCs). A chitosan-polyaniline hydrogel was synthesized, followed by characterization tests, such as Fourier transform infrared spectroscopy (FTIR), electrical conductivity, Young modulus, and contact angle measurements. A chitosan-PANI scaffold with a biomimetic topography was fabricated by molding it on a chemically fixed culture of PC12 cells. This substrate was used to test the hypothesis that the PC12 cell-imprinted chitosan-PANI hydrogel provides the required hierarchical topographical surface to induce neural differentiation. To test the importance of spatial imprinting, rADSCs were seeded on these conductive patterned substrates, and the resulting cultures were compared to those of the same cells grown on flat conductive chitosan-polyaniline, and flat pure chitosan substrates for evaluation of adhesion, cell viability, and expression of neural differentiation markers. The morphology of rADSCs grown on conductive patterned scaffolds noticeably was significantly different from that of stem cells cultivated on flat scaffolds. This difference suggests that the change in cell and nuclear shape imposed by the patterned conductive substrate leads to altered gene expression and neural differentiation of cultured cells. In summary, a conductive chitosan-polyaniline scaffold with biomimetic topography demonstrates a promising method for enhancing the neural differentiation of rADSCs for the treatment of neurodegenerative diseases.

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