Age at Menarche and Risk of Respiratory Diseases

2019 ◽  
pp. 9-16
Author(s):  
Martyna Zurawiecka ◽  
Iwona Wronka
Keyword(s):  
Respiratory Diseases ◽  
Age At Menarche

Delayed age at menarche in chronic respiratory diseases

2020 ◽  
Author(s):  
Rossella Gaudino ◽  
Sarah Dal Ben ◽  
Paolo Cavarzere ◽  
Sonia Volpi ◽  
Claudia Piona ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Age At Menarche ◽  
Chronic Respiratory Diseases

Gut microbiome a promising target for management of respiratory diseases

2020 ◽  
Vol 477 (14) ◽  
pp. 2679-2696
Author(s):  
Riddhi Trivedi ◽  
Kalyani Barve
Keyword(s):  
Respiratory Diseases ◽  
New Technology ◽  
Bacterial Flora ◽  
Systemic Circulation ◽  
The Body ◽  
Lung Pathology ◽  
Promising Target ◽  
Current Therapies ◽  
Intestinal Microbial Flora ◽  
On Chip

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.

Father absence, age at menarche, and sexual behaviors in women: Evaluating the genetic confounding hypothesis using the androgen receptor gene.

2019 ◽  
Vol 13 (3) ◽  
pp. 205-222 ◽  
Author(s):  
Gabriel L. Schlomer ◽  
Jessica Murray ◽  
Brianna Yates ◽  
Kerry Hair ◽  
David J. Vandenbergh
Keyword(s):  
Androgen Receptor ◽  
Sexual Behaviors ◽  
Receptor Gene ◽  
Father Absence ◽  
Androgen Receptor Gene ◽  
Age At Menarche

Association between reproductive factors and postmenopausal osteoporosis

2011 ◽  
Vol 20 (03) ◽  
pp. 248-251
Author(s):  
H. R. Meybodi ◽  
N. Khalili ◽  
P. Khashayar ◽  
R. Heshmat ◽  
A. Hossein-nezhad ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Reproductive Factors ◽  
Population Based ◽  
Age At Menarche ◽  
Mineral Density ◽  
Cross Sectional ◽  
Number Of Children ◽  
Menstrual History ◽  
Duration Of Breastfeeding

SummaryThe present cross-sectional research was designed to study possible correlations between clinical reproductive factors and bone mineral density (BMD) values.Using the data gathered by the population-based Iranian Multicenter Osteoporosis Study (IMOS), we investigated the correlation found between reproductive factors and osteoporosis. Subjects were recruited from five major cities of Iran. Bone mineral density was measured using Dual-Energy X-ray Absorptiometry and the results were analyzed against the age at menarche and at menopause, number of pregnancies, children and abortions, and the history (and duration) of breastfeeding.Data was available for 2528 women. Gravidity and number of children were reversely correlated with BMD. Younger age at menarche was associated with higher BMD values, whereas there was no significant correlation between age at menopause and menstrual history and BMD.Our study suggests that clinical reproductive factors, particularly number of children and breastfeeding, could be incorporated as predictors of BMD levels in women. Given the controversial results obtained in different studies, longitudinal studies should be carried out to enlighten the importance of these factors and the rationale of their use to predict BMD values in different settings.

Clinical features and outcome of acquired haemophilia A

2010 ◽  
Vol 30 (03) ◽  
pp. 156-161 ◽  
Author(s):  
R. Gheisari ◽  
B. Bomke ◽  
T. Hoffmann ◽  
R. E. Scharf
Keyword(s):  
Respiratory Diseases ◽  
Care Center ◽  
Treatment Algorithm ◽  
Early Death ◽  
Underlying Disease ◽  
Pulmonary Sarcoidosis ◽  
Relative Increase ◽  
Laboratory Evaluation ◽  
Haemophilia A ◽  
Acquired Haemophilia

SummaryWe have performed a monocenter study on 29 consecutive patients with acquired haemophilia A who were referred for diagnosis and treatment to the Düsseldorf Haemophilia Comprehensive Care Center between March 2001 and February 2010. Patients, methods: 18 men (age: 44–86 years) and 11 women (age: 20–83 years). For laboratory evaluation, a standardized staged protocol of aPTT, FVIII : C activity and concentration, mixing studies with patient and normal plasma, and quantification of inhibitor titers (Bethesda assay) was used. Diagnostic work-up included elaborate examinations for any underlying disease. Results: In 18 (62%) of the 29 patients with acquired haemophilia A, an underlying disorder was identified, including 9 patients with respiratory diseases (31%), 7 patients with autoimmune disorders (24%), one with malignancy, and one with postpartum state, while in 11 patients (38%) acquired haemophilia A remained idiopathic. Haemotherapy of bleeding, suppression or elimination of the inhibitor, and induction of immunotolerance to endogenous FVIII:C were performed according to a treatment algorithm. Predefined clinical endpoints were control of bleeding, eradication of the inhibitor, complete or partial remission (CR, PR), relapse, or early death (≤30 days). Of the 29 patients in total, 22 individuals achieved CR (76%), three had PR, one relapsed, and three died within 30 days (one of acute myocardial infarction while on anti-haemorrhagic treatment, one of sepsis while on immunosuppression due to active acquired haemophilia A, one of lung bleeding in association with pre-existing pulmonary sarcoidosis). Conclusion: This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in the proportion of patients with respiratory diseases is present.

Evaluation of the concentration of particulate material and its impact on the respiratory diseases of the workers of an artesanal smelting huarochirí. Lima

2018 ◽  
Vol 2 (1) ◽  
pp. 13
Author(s):  
Walter Manuel Vicharra ◽  
Carlos Cabrera
Keyword(s):  
Respiratory Diseases ◽  
San Antonio ◽  
Particulate Material ◽  
Quality Monitoring ◽  
Gravimetric Analysis ◽  
Air Quality Monitoring ◽  
Analysis Method ◽  
Particulate Materials ◽  
Health Assessments ◽  
Medical Examinations

The main objective of esta research is to determine the level of concentration of particulate materials of the size of 10 microns and 2.5 microns of an artisanal foundry, and to Evaluate the health in workers' respiratory diseases, as well as to find a relationship Between the particulate materials and the respiratory diseases, Which the project is located in the district of San Antonio, Department of Huarochiri, Department of Lima, Peru - 2017. The gravimetric analysis method approved by the General Directorate of Environmental Health DIGESA was used, with the Protocol for air quality monitoring and data management, to determine the level of concentration of particulate material and on the other hand Health Assessments in respiratory diseases Were used a survey made by a doctor in pulmonology, Which was Then backed by medical examinations performed on workers. It was Determined That the particulate materials of 10 microns and 2.5 microns Were above environmental quality standards, Which is Considered as risky for the health of people, and in respiratory diseases it was Concluded That some of the subjects of the population of study are With occupational diseases.

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