Coupling of Blood Pressure and Subarachnoid Space Oscillations at Cardiac Frequency Evoked by Handgrip and Cold Tests: A Bispectral Analysis

Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency

PLoS ONE ◽

10.1371/journal.pone.0172842 ◽

2017 ◽

Vol 12 (2) ◽

pp. e0172842 ◽

Cited By ~ 4

Author(s):

Magdalena Wszedybyl-Winklewska ◽

Jacek Wolf ◽

Ewa Swierblewska ◽

Katarzyna Kunicka ◽

Agnieszka Gruszecka ◽

...

Keyword(s):

Blood Pressure ◽

Subarachnoid Space ◽

Acute Hypoxia ◽

Cardiac Frequency ◽

The Relationship ◽

Space Width

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Intracranial pressure waves: characterization of a pulsation absorber with notch filter properties using systems analysis

Journal of Neurosurgery Pediatrics ◽

10.3171/ped/2008/2/7/083 ◽

2008 ◽

Vol 2 (1) ◽

pp. 83-94 ◽

Cited By ~ 28

Author(s):

Rui Zou ◽

Eun-Hyoung Park ◽

Erin McCormack Kelly ◽

Michael Egnor ◽

Mark E. Wagshul ◽

...

Keyword(s):

Blood Pressure ◽

Cerebrospinal Fluid ◽

Intracranial Pressure ◽

Transfer Function ◽

Input Signal ◽

Systems Analysis ◽

Notch Filter ◽

Time Varying ◽

Cardiac Frequency ◽

Arterial Blood

Object The relationship between the waveform of intracranial pressure (ICP) and arterial blood pressure can be quantitatively characterized using a newly developed technique in systems analysis, the time-varying transfer function. This technique considers the arterial blood pressure as an input signal composed of multiple frequencies represented in the output ICP according to the transfer function imposed by the intracranial system on the input signal. The transfer function can change with time and with physiological manipulations. The authors examined data obtained from canine experiments involving manipulations of ICP. Methods The authors analyzed 11 experiments from 3 normal mongrel dogs under conditions of normal ICP and with changes in ICP made by bolus injection, infusion, or withdrawal of cerebrospinal fluid by using time-varying transfer function. Results During normal ICP periods, the gain of the transfer function displayed a deep notch (≥ 1 log unit) centered at or near the cardiac frequency. In systems terms, the intracranial compartment under normal conditions appears to act as a notch filter attenuating the cardiac frequency input relative to other frequencies. Epochs of ICP elevation showed suppression of the notch, and the notch was restored when ICP returned to normal. Conclusions The intracranial system in these animals could be considered to include a pulsation absorber for which the target frequency appears to be close to the cardiac frequency. One possible source for such an absorber mechanism might be the free movement of cerebrospinal fluid, implying that impairment of this motion may have important clinical implications in various neurological conditions such as hydrocephalus.

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247 Effects of effort intensity in aerobic training on cardiac frequency, blood pressure, VO2max and 5000m running performance

Journal of Science and Medicine in Sport ◽

10.1016/s1440-2440(07)70254-2 ◽

2007 ◽

Vol 10 ◽

pp. 85

Keyword(s):

Blood Pressure ◽

Aerobic Training ◽

Running Performance ◽

Cardiac Frequency

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Unilateral Spinal Anaesthesia in Calves

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.22239 ◽

2020 ◽

Vol 70 (4) ◽

pp. 1883

Author(s):

S. YAYLA ◽

E. KILIC ◽

U. AYDIN ◽

I. OZAYDIN ◽

V. BARAN ◽

...

Keyword(s):

Blood Pressure ◽

Arterial Blood Pressure ◽

Spinal Anaesthesia ◽

Subarachnoid Space ◽

Femoral Fractures ◽

Lateral Position ◽

Depth Of Anaesthesia ◽

Hyperbaric Bupivacaine ◽

Arterial Blood ◽

Systolic Arterial Blood Pressure

In this study, we aimed to evaluate the effects of unilateral anaesthesia by the administration of hyperbaric bupivacaine through the lumbosacral space into the subarachnoid space in calves. A total of 10 calves with unilateral femoral fractures were included in the study. After each calf was placed in a lateral position on the side intended for surgery, 15 mg of hyperbaric bupivacaine was slowly injected into the subarachnoid space. The onset, duration and depth of anaesthesia were determined by the pinprick test (scale 1–4). In addition, heart rate, diastolic arterial blood pressure, systolic arterial blood pressure, mean arterial blood pressure, respiratory rate and body temperature of the calves were monitored and recorded from the onset to 120 min after anaesthesia. The onset of unilateral spinal anaesthesia was within 20 s and the mean duration of anaesthesia was 155.40 min. Although there were statistical differences between hemodynamic values in the study, they were within the reference values. As a result, we believe that unilateral spinal anaesthesia in calves provides adequate anaesthesia for use in orthopaedic procedures; thus, it can be used in practice.

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Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans

Scientific Reports ◽

10.1038/s41598-019-42552-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 5

Author(s):

Magdalena K. Nuckowska ◽

Marcin Gruszecki ◽

Jacek Kot ◽

Jacek Wolf ◽

Wojciech Guminski ◽

...

Keyword(s):

Blood Pressure ◽

Subarachnoid Space ◽

Slow Breathing ◽

Space Width

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Coupling between Blood Pressure and Subarachnoid Space Width Oscillations during Slow Breathing

Entropy ◽

10.3390/e23010113 ◽

2021 ◽

Vol 23 (1) ◽

pp. 113

Author(s):

Agnieszka Gruszecka ◽

Magdalena K. Nuckowska ◽

Monika Waskow ◽

Jacek Kot ◽

Pawel J. Winklewski ◽

...

Keyword(s):

Blood Pressure ◽

Subarachnoid Space ◽

Brain Hemispheres ◽

New Findings ◽

Inspiratory Resistance ◽

Cardiac Component ◽

Slow Breathing ◽

Effective Phase ◽

Space Width ◽

The Brain

The precise mechanisms connecting the cardiovascular system and the cerebrospinal fluid (CSF) are not well understood in detail. This paper investigates the couplings between the cardiac and respiratory components, as extracted from blood pressure (BP) signals and oscillations of the subarachnoid space width (SAS), collected during slow ventilation and ventilation against inspiration resistance. The experiment was performed on a group of 20 healthy volunteers (12 females and 8 males; BMI =22.1±3.2 kg/m2; age 25.3±7.9 years). We analysed the recorded signals with a wavelet transform. For the first time, a method based on dynamical Bayesian inference was used to detect the effective phase connectivity and the underlying coupling functions between the SAS and BP signals. There are several new findings. Slow breathing with or without resistance increases the strength of the coupling between the respiratory and cardiac components of both measured signals. We also observed increases in the strength of the coupling between the respiratory component of the BP and the cardiac component of the SAS and vice versa. Slow breathing synchronises the SAS oscillations, between the brain hemispheres. It also diminishes the similarity of the coupling between all analysed pairs of oscillators, while inspiratory resistance partially reverses this phenomenon. BP–SAS and SAS–BP interactions may reflect changes in the overall biomechanical characteristics of the brain.

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Objective Assessment of the Sympatholytic Action of Nei-Kuan Acupoint

The American Journal of Chinese Medicine ◽

10.1142/s0192415x0100023x ◽

2001 ◽

Vol 29 (02) ◽

pp. 201-210 ◽

Cited By ~ 16

Author(s):

Francisco Abad-Alegrìa ◽

Carlos Pomaròn ◽

Cristina Aznar ◽

Cristina Muñoz ◽

Sonia Adelantado

Keyword(s):

Blood Pressure ◽

Median Nerve ◽

Nerve Stimulation ◽

Electrical Response ◽

Objective Assessment ◽

Animal Experiments ◽

Electrical Stimulus ◽

Cardiac Frequency ◽

Specific Effects ◽

Median Nerve Stimulation

From animal experiments and clinical trials, we can think that acupuncture of Nei-Kuan (EH-6) is effective in the control of some vegetative functions. We have tried to determine the real reach of these assumptions by means of simple quantitative measurement methods, such as detection of cardiac frequency and systolic and diastolic blood pressure, and the sympathetic electrical response. The experiments were performed on 29 healthy volunteers. Basal values of these parameters were recorded, and also after orthodox Nei-Kuan acupuncture, non-acupunctural point puncture, supine lying by 15 min, Chü-Tze (EH-3) acupuncture and bipolar electrical stimulus of the median nerve at the Nei-Kuan level in the wrist. Such conditions were designed to evaluate non-specific puncture, repose and direct median nerve stimulation influences in the effects of Nei-Kuan acupuncture. We conclude that Nei-Kuan acupuncture strongly inhibits sympathetic tone, with reduction of cardiac frequency, systolic blood pressure and an important reduction of the amplitude of the sympathetic electrical response; the latency of the electrical response was also prolonged. Some weak effects on blood pressure and cardiac frequency were observed also, as non-specific effects of puncture and median nerve stimulation. From previous anatomical data, we hypothesize that the level of such actions is suprametameric, with strong implication of the diencephalon and cerebral cortex.

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Orthopaedic Timing in Polytrauma in a Second Level Emergency Hospital. An Overrated Problem?

The Open Orthopaedics Journal ◽

10.2174/1874325001509010296 ◽

2015 ◽

Vol 9 (1) ◽

pp. 296-302

Author(s):

Dei Giudici V ◽

Giampaolini N ◽

Panfighi A ◽

Marinelli M ◽

Procaccini R ◽

...

Keyword(s):

Blood Pressure ◽

Clinical Presentation ◽

Laboratory Data ◽

Main Concern ◽

Surgical Timing ◽

Cardiac Frequency ◽

Level Ii ◽

Interesting Correlation ◽

Patient’S Outcome ◽

Surgical Condition

The main concern for orthopaedic treatment in polytrauma has always been the same for almost forty years, which also regards “where” and “when” to proceed; correct surgical timing and correct interpretation of the DCO concept are still being debated. In the last few years, several attempts have been made to classify patients based on their clinical presentation and by trying to figure out which vital parameters are able to predict the patient’s outcome. This study evaluated all patients who presented with code red at the Emergency Department of our Hospital, a level II trauma center. For every patient, the following characteristics were noted: sex, age, day of hospitalization, orthopaedic trauma, time to surgery, presence of an associated surgical condition in the fields of general surgery, thoracic surgery, neurosurgery and vascular surgery, cardiac frequency, blood pressure, oxygen saturation, Glasgow Coma Scale and laboratory data. All patients included were divided into subgroups based on orthopaedic surgical timing. Two other subgroups were also identified and analyzed in detail: deceased and weekend traumas. A total of 208 patients were included. Our primary goal was to identify a correlation between the mortality and surgical timing of the orthopaedic procedures; our secondary goal was to recognize, if present, a statistically relevant association between historical, clinical and laboratory data, and mortality rate, defining any possible risk factor. A correlation between mortality and orthopaedic surgical timing was not found. Analyzing laboratory data revealed an interesting correlation between mortality and: blood pressure, platelet count, cardiac frequency, hematocrit, hemoglobin and age.

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