Dental Stem Cells and Tooth Regeneration

2018 ◽  
pp. 41-52 ◽  
Author(s):  
Yi Shuai ◽  
Yang Ma ◽  
Tao Guo ◽  
Liqiang Zhang ◽  
Rui Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tooth Regeneration ◽  
Dental Stem Cells

Dental stem cells for tooth regeneration and repair

2009 ◽  
Vol 9 (9) ◽  
pp. 1143-1154 ◽  
Author(s):  
Andrea Mantesso ◽  
Paul Sharpe
Keyword(s):  
Stem Cells ◽  
Tooth Regeneration ◽  
Dental Stem Cells

scholarly journals Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration: A Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Yun-Jong Park ◽  
Seunghee Cha ◽  
Young-Seok Park
Keyword(s):  
Stem Cells ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Tooth Regeneration ◽  
Future Perspectives ◽  
Dental Stem Cells ◽  
Original Function ◽  
Tooth Structure ◽  
Promising Source

Tooth derived stem cells or dental stem cells are categorized according to the location from which they are isolated and represent a promising source of cells for regenerative medicine. Originally, as one kind of mesenchymal stem cells, they are considered an alternative of bone marrow stromal cells. They share many commonalties but maintain differences. Considering their original function in development and the homeostasis of tooth structures, many applications of these cells in dentistry have aimed at tooth structure regeneration; however, the application in other than tooth structures has been attempted extensively. The availability from discarded or removed teeth can be an innate benefit as a source of autologous cells. Their origin from the neural crest results in exploitation of neurological and numerous other applications. This review briefly highlights current and future perspectives of the regenerative applications of tooth derived stem cells in areas beyond tooth regeneration.

TOOTH REGENERATION WITH DENTAL STEM CELL RESEARCH IN MINIATURE PIG MODEL

2015 ◽  
Vol 41 (03) ◽  
pp. 197-203
Author(s):  
Tzong-Fu Kuo ◽  
Shi-Yuan Sheu ◽  
Ching-Chuan Jiang ◽  
Hao-Hueng Chang ◽  
Shuo-Tsung Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Type I ◽  
Tooth Regeneration ◽  
Tooth Crown ◽  
Dental Stem Cells ◽  
Posterior Teeth ◽  
Anterior Teeth ◽  
Tooth Buds ◽  
Mini Pigs

To develop a cell-based approach to tooth regeneration, we isolated dental stem cells from tooth buds of mini pigs and culture-expanded them for about three weeks. Flow cytometry revealed that the majority of the proliferating cells were positive for stem cell surface markers, including CD105, CD29, CD44, CD71. These dental stem cells were then seeded in biodegradable agarose gel for autograft in various areas of the jaw bone. Mini pigs with tooth buds removed without transplantation of dental stem cells served as control. After one year, well differentiated tooth crown and root sheath were formed in mini pigs in the experimental group. The tooth formed by dental stem cells transplanted in alveolar bone was similar in size to original tooth crown (approximately 2 cm × 2 cm × 2 cm). The teeth formed by dental stem cells transplanted under the roots of the anterior teeth and in the cortical bone area were smaller. In the control group, the space where the tooth bud was extracted without cell transplantation was seen to be closed by forward movement of the posterior teeth. Histological analysis showed the structures of enamel, dentin and pulp in the regenerated tooth crown. Immunohistochemical analysis of amelogenin, type I collagen and bone sialoprotein confirmed enamel and dentin formation. Enamel and dentin structures on the regenerated tooth were also identified using scanning electron microscopy. These findings demonstrate a successful model of tooth regeneration from dental stem cells in mini pigs. In addition, local environment and available space also significantly affect the extent of tissue regeneration. Our study demonstrates the feasibility of using dental stem cells for tooth regeneration in clinical applications.

Dental stem cells in tooth regeneration and repair in the future

2017 ◽  
Vol 18 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Christian Morsczeck ◽  
Torsten E. Reichert
Keyword(s):  
Stem Cells ◽  
Tooth Regeneration ◽  
Dental Stem Cells ◽  
The Future

scholarly journals Human Amniotic Membrane as a Matrix for Endothelial Differentiation of VEGF-Treated Dental Stem Cells

2019 ◽  
Vol 12 (6) ◽  
pp. 599-613 ◽  
Author(s):  
Siti Nurnasihah Md Hashim ◽  
Muhammad Fuad Hilmi Yusof ◽  
Wafa’ Zahari ◽  
Hamshawagini Chandra ◽  
Khairul Bariah Ahmad Amin Noordin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Membrane ◽  
Endothelial Differentiation ◽  
Human Amniotic Membrane ◽  
Dental Stem Cells

Immunomodulatory properties and in vivo osteogenesis of human dental stem cells from fresh and cryopreserved dental follicles

2015 ◽  
Vol 90 (1-3) ◽  
pp. 48-58 ◽  
Author(s):  
Young-Hoon Kang ◽  
Hye-Jin Lee ◽  
Si-Jung Jang ◽  
June-Ho Byun ◽  
Jong-Sil Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Stem Cells ◽  
Immunomodulatory Properties

scholarly journals Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Bossù ◽  
Andrea Pacifici ◽  
Daniele Carbone ◽  
Gianluca Tenore ◽  
Gaetano Ierardo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Current Knowledge ◽  
Dental Stem Cells ◽  
Therapeutic Tool ◽  
Exponential Increase ◽  
Major Interest ◽  
Adult Mesenchymal Stem Cells ◽  
Therapeutic Protocols ◽  
Near Future

In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

scholarly journals Tumorigenicity analysis of heterogeneous dental stem cells and its self-modification for chromosome instability

Cell Cycle ◽  
2015 ◽  
Vol 14 (21) ◽  
pp. 3396-3407 ◽  
Author(s):  
Zhaosong Meng ◽  
Guoqing Chen ◽  
Jinlong Chen ◽  
Bo Yang ◽  
Mei Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Chromosome Instability ◽  
Dental Stem Cells
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