Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

2018 ◽  
pp. 73-89 ◽  
Author(s):  
Maryam Rahmati ◽  
Cristian Pablo Pennisi ◽  
Ali Mobasheri ◽  
Masoud Mozafari
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Regenerative Medicine

scholarly journals Stem Cell Based Tissue Engineering and Regenerative Medicine: A Review Focusing on Adult Stem Cells

2012 ◽  
Vol 1 (1) ◽  
pp. 75-82
Author(s):  
Jordan Greenberg ◽  
Veronica Fortino ◽  
Daniel Pelaez ◽  
Herman S. Cheung
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Adult Stem Cells

Exploring and Exploiting Tissue Engineering Through the Design of Multifunctional Therapeutic Systems

2019 ◽  
Vol 14 (2) ◽  
pp. 80-82 ◽  
Author(s):  
Masoud Mozafari
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Research ◽  
Therapeutic Strategies ◽  
Common Theme ◽  
Special Issue ◽  
The Common ◽  
Lead Article

This article presents a special issue of "Current Stem Cell Research & Therapy" devoted to exploring and exploiting tissue engineering through the design of multifunctional therapeutic systems. This lead article draws from twelve contributed articles to discuss the most recent advancements in this emerging field. The common theme in the contributed articles is the emerging therapeutic strategies, and a special appeal is made for collaboration between engineers and biologists for the development of multifunctional therapeutic systems for tissue engineering and regenerative medicine.

scholarly journals Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Muhammad Shafiq ◽  
Onaza Ali ◽  
Seong-Beom Han ◽  
Dong-Hwee Kim
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Tissue Repair ◽  
Cell Function ◽  
Target Site ◽  
Inflammatory Microenvironment ◽  
Cell Functionality ◽  
Cell Cell

Stem cells have been extensively used in regenerative medicine and tissue engineering; however, they often lose their functionality because of the inflammatory microenvironment. This leads to their poor survival, retention, and engraftment at transplantation sites. Considering the rapid loss of transplanted cells due to poor cell-cell and cell-extracellular matrix (ECM) interactions during transplantation, it has been reasoned that stem cells mainly mediate reparative responses via paracrine mechanisms, including the secretion of extracellular vesicles (EVs). Ameliorating poor cell-cell and cell-ECM interactions may obviate the limitations associated with the poor retention and engraftment of transplanted cells and enable them to mediate tissue repair through the sustained and localized presentation of secreted bioactive cues. Biomaterial-mediated strategies may be leveraged to confer stem cells enhanced immunomodulatory properties, as well as better engraftment and retention at the target site. In these approaches, biomaterials have been exploited to spatiotemporally present bioactive cues to stem cell-laden platforms (e.g., aggregates, microtissues, and tissue-engineered constructs). An array of biomaterials, such as nanoparticles, hydrogels, and scaffolds, has been exploited to facilitate stem cells function at the target site. Additionally, biomaterials can be harnessed to suppress the inflammatory microenvironment to induce enhanced tissue repair. In this review, we summarize biomaterial-based platforms that impact stem cell function for better tissue repair that may have broader implications for the treatment of various diseases as well as tissue regeneration.

Tissue Engineering for Stem Cell Mediated Regenerative Medicine

2010 ◽  
pp. 377-399
Author(s):  
Janet Zoldan ◽  
Thomas P. Kraehenbuehl ◽  
Abigail K. R. Lytton-Jean ◽  
Robert S. Langer ◽  
Daniel G. Anderson
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Regenerative Medicine

scholarly journals Regenerative medicine in China: demands, capacity, and regulation

2016 ◽  
Vol 4 ◽  
pp. 1-7 ◽  
Author(s):  
Biao Cheng ◽  
Shuliang Lu ◽  
Xiaobing Fu
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Transplantation ◽  
Local Governments ◽  
Management Practices ◽  
Strong Support ◽  
Cell Reprogramming ◽  
Healthy Development ◽  
Interdisciplinary Field

Abstract Regenerative medicine (RM) is an emerging interdisciplinary field of research. Its clinical application focuses on the repair, replacement, and regeneration of cells, tissues, and organs by approaches including cell reprogramming, stem cell transplantation, tissue engineering, activating factors, and clone treatment. RM has become a hot point of research in China and other countries. China’s main and local governments have attached great importance to RM and given strong support in relevant policies and funding. About 3.5 billion RMB has been invested in this field. Since 1999, China has established about 30 RM centers and cooperates with many advanced countries in RM research and benefits from their cooperation. However, China needs to develop standards, regulations, and management practices suitable for the healthy development of RM. In this review, we focus on its great demand, capacity, and relative regulations.

Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn’s Disease

2021 ◽  
Author(s):  
Hojjatollah Nazari ◽  
Vahid Yaghoubi Naei ◽  
Asieh Heirani Tabasi ◽  
Abolfazl Badripour ◽  
Reza Akbari Asbagh ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Regenerative Medicine ◽  
Surgical Techniques ◽  
Perianal Fistula ◽  
In Vivo Studies ◽  
Separation And Purification

Abstract Regenerative medicine is an emerging therapeutic method that aims to reconstruct tissues and organs. This advanced therapeutic approach has demonstrated great potential in addressing the limitations of medical and surgical procedures for treating perineal fistula in patients with Crohn’s disease. Recent developments in stem cell technology have led to a massive good manufacturing practices (GMPs) production of various stem cells, including mesenchymal and embryonic cells, along with induction of pluripotent stem cells to repair damaged tissues in the fistula. The recent advances in separation and purification of exosomes, as biologic nanovesicles carrying anti-inflammatory and regenerative agents, have made them powerful tools to treat this inflammatory disease. Further, tremendous advances in nanotechnology, biomaterials, and scaffold fabrication methods enable tissue engineering methods to synthesize tissue-like structures to assist surgical techniques. This review focuses on advanced regenerative-based methods including stem cell therapy, exosome therapy, and tissue engineering used in the treatment of perianal fistula. Relevant in vitro and in vivo studies and the latest innovations in implementation of regenerative medicine for this disease are also separately reviewed. Additionally, current challenges regarding implementation of g stem cells, exosomes, and tissue engineering methods for bridging the gaps between laboratory findings and clinic application will be discussed.

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