Next-Generation Sequencing of Hepatitis C Virus (HCV) Mixed-Genotype Infections in Anti-HCV-Negative Blood Donors

2018 ◽  
pp. 65-71 ◽  
Author(s):  
Maciej Janiak ◽  
Kamila Caraballo Cortés ◽  
Karol Perlejewski ◽  
Dorota Kubicka-Russel ◽  
Piotr Grabarczyk ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
Blood Donors ◽  
Next Generation ◽  
Mixed Genotype ◽  
Generation Sequencing

Genetic diversity of Hepatitis C Virus in Pakistan using Next Generation Sequencing

2018 ◽  
Vol 108 ◽  
pp. 26-31 ◽  
Author(s):  
Sana Saleem ◽  
Amjad Ali ◽  
Bushra Khubaib ◽  
Madiha Akram ◽  
Zareen Fatima ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Generation Sequencing

Next-generation sequencing for the clinical management of hepatitis C virus infections: does one test fits all purposes?

2019 ◽  
Vol 56 (6) ◽  
pp. 420-434 ◽  
Author(s):  
Lize Cuypers ◽  
Marijn Thijssen ◽  
Arash Shakibzadeh ◽  
Farzaneh Sabahi ◽  
Mehrdad Ravanshad ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
Clinical Management ◽  
Next Generation ◽  
Virus Infections ◽  
Generation Sequencing

scholarly journals Next-Generation Sequencing Reveals Frequent Opportunities for Exposure to Hepatitis C Virus in Ghana

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145530 ◽  
Author(s):  
Joseph C. Forbi ◽  
Jennifer E. Layden ◽  
Richard O. Phillips ◽  
Nallely Mora ◽  
Guo-liang Xia ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals A Phylogenetic Analysis of Hepatitis C Virus Transmission, Relapse, and Reinfection Among People Who Inject Drugs Receiving Opioid Agonist Therapy

2020 ◽  
Vol 222 (3) ◽  
pp. 488-498 ◽  
Author(s):  
Matthew J Akiyama ◽  
Daniel Lipsey ◽  
Lilia Ganova-Raeva ◽  
Lili T Punkova ◽  
Linda Agyemang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
People Who Inject Drugs ◽  
Next Generation ◽  
Agonist Therapy ◽  
Opioid Agonist ◽  
Opioid Agonist Therapy ◽  
Generation Sequencing

Abstract Background Understanding hepatitis C virus (HCV) transmission among people who inject drugs (PWID) is essential for HCV elimination. We aimed to differentiate reinfections from treatment failures and to identify transmission linkages and associated factors in a cohort of PWID receiving opioid agonist therapy (OAT). Methods We analyzed baseline and follow-up specimens from 150 PWID from 3 OAT clinics in the Bronx, New York. Next-generation sequencing data from the hypervariable region 1 of HCV were analyzed using Global Hepatitis Outbreak and Surveillance Technology. Results There were 3 transmission linkages between study participants. Sustained virologic response (SVR) was not achieved in 9 participants: 7 had follow-up specimens with similar sequences to baseline, and 2 died. In 4 additional participants, SVR was achieved but the participants were viremic at later follow-up: 2 were reinfected with different strains, 1 had a late treatment failure, and 1 was transiently viremic 17 months after treatment. All transmission linkages were from the same OAT clinic and involved spousal or common-law partnerships. Conclusion This study highlights the use of next-generation sequencing as an important tool for identifying viral transmission and to help distinguish relapse and reinfection among PWID. Results reinforce the need for harm reduction interventions among couples and those who report ongoing risk factors after SVR.

scholarly journals First identification of a recombinant form of hepatitis C virus in Austrian patients by full-genome next generation sequencing

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181273 ◽  
Author(s):  
Evelyn Stelzl ◽  
Bernhard Haas ◽  
Bernd Bauer ◽  
Sherry Zhang ◽  
Ellen H. Fiss ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
Recombinant Form ◽  
Full Genome ◽  
Next Generation ◽  
Generation Sequencing

Near full length hepatitis C virus genome reconstruction by next generation sequencing based on genotype-independent amplification

2015 ◽  
Vol 47 (7) ◽  
pp. 608-612 ◽  
Author(s):  
Barbara Bartolini ◽  
Emanuela Giombini ◽  
Isabella Abbate ◽  
Marina Selleri ◽  
Gabriella Rozera ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Next Generation Sequencing ◽  
Virus Genome ◽  
Full Length ◽  
Next Generation ◽  
Genome Reconstruction ◽  
Generation Sequencing
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