scholarly journals Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine

2017 ◽  
pp. 169-192 ◽  
Author(s):  
Marta Fumagalli ◽  
Davide Lecca ◽  
Giusy T. Coppolino ◽  
Chiara Parravicini ◽  
Maria P. Abbracchio
Keyword(s):  
Regenerative Medicine ◽  
Pharmacological Properties ◽  
Biological Functions ◽  
Potential Target

scholarly journals Tissue Engineering Therapies Based on Folic Acid and Other Vitamin B Derivatives. Functional Mechanisms and Current Applications in Regenerative Medicine

2018 ◽  
Vol 19 (12) ◽  
pp. 4068 ◽  
Author(s):  
Daniel Fernández-Villa ◽  
Mirta Jiménez Gómez-Lavín ◽  
Cristina Abradelo ◽  
Julio San Román ◽  
Luis Rojo
Keyword(s):  
Tissue Engineering ◽  
Folic Acid ◽  
Regenerative Medicine ◽  
Bioactive Compounds ◽  
Metabolic Pathways ◽  
B Vitamins ◽  
Vitamin B ◽  
Biological Functions ◽  
Great Stability ◽  
Functional Mechanisms

B-vitamins are a group of soluble vitamins which are cofactors of some of the enzymes involved in the metabolic pathways of carbohydrates, fats and proteins. These compounds participate in a number of functions as cardiovascular, brain or nervous systems. Folic acid is described as an accessible and multifunctional niche component that can be used safely, even combined with other compounds, which gives it high versatility. Also, due to its non-toxicity and great stability, folic acid has attracted much attention from researchers in the biomedical and bioengineering area, with an increasing number of works directed at using folic acid and its derivatives in tissue engineering therapies as well as regenerative medicine. Thus, this review provides an updated discussion about the most relevant advances achieved during the last five years, where folic acid and other vitamins B have been used as key bioactive compounds for enhancing the effectiveness of biomaterials’ performance and biological functions for the regeneration of tissues and organs.

scholarly journals RNA Editing and Drug Discovery for Cancer Therapy

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Wei-Hsuan Huang ◽  
Chao-Neng Tseng ◽  
Jen-Yang Tang ◽  
Cheng-Hong Yang ◽  
Shih-Shin Liang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Natural Products ◽  
Drug Discovery ◽  
Cancer Therapy ◽  
Rna Editing ◽  
Cell Function ◽  
Biological Functions ◽  
Potential Target ◽  
Literature Overview

RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.

scholarly journals Hyaluronic acid (hyaluronan): a review

2008 ◽  
Vol 53 (No. 8) ◽  
pp. 397-411 ◽  
Author(s):  
J. Necas ◽  
L. Bartosikova ◽  
P. Brauner ◽  
J. Kolar
Keyword(s):  
Hyaluronic Acid ◽  
Integral Membrane Proteins ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Biological Functions ◽  
Connective Tissues ◽  
Vitreous Fluid ◽  
Hyaluronan Synthases ◽  
Naturally Occurring ◽  
Umbilical Cords

Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including humans. It is found in most connective tissues and is particularly concentrated in synovial fluid, the vitreous fluid of the eye, umbilical cords and chicken combs. It is naturally synthesized by a class of integral membrane proteins called hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases. This review describes metabolisms, different physiological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid.

scholarly journals TOX as a potential target for immunotherapy in lymphocytic malignancies

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Chaofeng Liang ◽  
Shuxin Huang ◽  
Yujie Zhao ◽  
Shaohua Chen ◽  
Yangqiu Li
Keyword(s):  
T Cell ◽  
Potential Role ◽  
Hematological Malignancies ◽  
High Mobility ◽  
High Mobility Group ◽  
Biological Functions ◽  
Hmg Box ◽  
Cell Exhaustion ◽  
Potential Target

AbstractTOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies.

scholarly journals Retinal Stem Cells Reprogramming Using Omotoxicological Pharmaceuticals Blend Therapy Through Retrobulbar Injections

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Regenerative Medicine ◽  
Biological Functions ◽  
Retinal Stem Cells

The author reports his experience derived from his first Autologous Stem Cells transplant from Bone Marrow (from the hip) and reimplantation into the retrobulbar fat of the Eye. To define a new concept of Informational Therapy for Regenerative Medicine using a system of Reformatting the pathological retina through the therapeutic Regulation of affected Tissues of the inner Eye no more capable to regulate normal biological functions.

Supramolecular self-assembly codes for functional structures

2007 ◽  
Vol 365 (1855) ◽  
pp. 1417-1433 ◽  
Author(s):  
Liam C Palmer ◽  
Yuri S Velichko ◽  
Monica Olvera de la Cruz ◽  
Samuel I Stupp
Keyword(s):  
Regenerative Medicine ◽  
Small Molecule ◽  
Self Assembly ◽  
Chemical Structure ◽  
Controlled Synthesis ◽  
Biological Functions ◽  
Size Scale

Small-molecule self-assembly has proven to be a rich field for the controlled synthesis of supramolecular objects with the size scale of polymers and interesting properties. Using several recent examples from our laboratory, we discuss the development of chemical structure codes for supramolecular self-assembly objects with defined shapes. The resulting materials formed by these objects are promising for electronic functions and biological functions for regenerative medicine.

Membrane–cytoskeleton interactions in cholesterol-dependent domain formation

2015 ◽  
Vol 57 ◽  
pp. 177-187 ◽  
Author(s):  
Jennifer N. Byrum ◽  
William Rodgers
Keyword(s):  
Biological Properties ◽  
Membrane Rafts ◽  
Membrane Domains ◽  
Biological Functions ◽  
Membrane Cytoskeleton ◽  
Heterogeneous Structures ◽  
Integral Role ◽  
Model Cell ◽  
Actomyosin Cytoskeleton ◽  
Dependent Domain

Since the inception of the fluid mosaic model, cell membranes have come to be recognized as heterogeneous structures composed of discrete protein and lipid domains of various dimensions and biological functions. The structural and biological properties of membrane domains are represented by CDM (cholesterol-dependent membrane) domains, frequently referred to as membrane ‘rafts’. Biological functions attributed to CDMs include signal transduction. In T-cells, CDMs function in the regulation of the Src family kinase Lck (p56lck) by sequestering Lck from its activator CD45. Despite evidence of discrete CDM domains with specific functions, the mechanism by which they form and are maintained within a fluid and dynamic lipid bilayer is not completely understood. In the present chapter, we discuss recent advances showing that the actomyosin cytoskeleton has an integral role in the formation of CDM domains. Using Lck as a model, we also discuss recent findings regarding cytoskeleton-dependent CDM domain functions in protein regulation.

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