Evaluation of Immune Indices and Serum Vitamin D Content in Children with Atopic Dermatitis

2017 ◽  
pp. 81-89 ◽  
Author(s):  
Agnieszka Lipińska-Opałka ◽  
Agata Wawrzyniak ◽  
Sławomir Lewicki ◽  
Robert Zdanowski ◽  
Bolesław Kalicki
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels

2020 ◽  
Author(s):  
Daniel R Drodge ◽  
Ashley Budu-Aggrey ◽  
Lavinia Paternoster
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Serum Vitamin ◽  
Strong Relationship ◽  
Reverse Direction ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Standard Deviations ◽  
The Relationship ◽  
Gwa Studies

AbstractAtopic dermatitis (AD) patients have been observed to have lower vitamin D levels. Previous studies have found little evidence that vitamin D levels causally influence the risk of AD, but the reverse direction has not yet been investigated.Here we used Mendelian Randomization to assess the causal relationship between AD and serum vitamin D levels, using genetic data from the most recent GWA studies of vitamin D and AD.There was little evidence for vitamin D levels causally influencing AD risk (odds per standard deviations increase in log-transformed vitamin D levels =1.233, 95% CI 0.927 to 1.639, P-value =0.150). However, genetic liability for AD raises serum vitamin D levels by 0.043 (95% CI 0.017 to 0.069) standard deviations per doubling of odds of disease (P-value =0.001). The AD-associated filaggrin (FLG) mutation R501X appears to show a particularly strong relationship with vitamin D. However, the relationship between AD and vitamin D holds when R501X is omitted (0.018, 95% CI 0.004 to 0.031, P-value =0.008).We found evidence that AD is causally associated with an increase in serum vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.

scholarly journals PECULIARITIES OF CLINICAL PASSING OF ATOPIC DERMATITIS AND VITAMIN D EXCHANGE IN EARLY CHILDREN

2020 ◽  
pp. 27-35
Author(s):  
N. V. Kamut ◽  
M. M. Kiselova
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Young Children ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Scientific Data ◽  
Main Group ◽  
Severe Atopic Dermatitis ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The article is devoted to the study of features of clinical course of atopic dermatitis and vitamin D exchange in young children conducted by us by estimation of severity of atopic dermatitis depending on the value of SCORAD index, determination of 25(OH)D concentration in serum of children by immunochemical method with chemocentric analysis according to the classification approved by experts of the international endocrinological society. In the examination of 188 young children, two groups were formed on the basis of the Lviv City Children's Clinical Hospital. Children from 1 month to 1 year of age with manifestations of atopic dermatitis (n = 120), who were born full-term and had no birth defects, metabolic disorders, severe perinatal CNS lesions formed the main group. The comparison group consisted of 68 healthy young children without chronic diseases. All children had atopic dermatitis in the main group and were classified by severity (depending on the SCORAD index): children with mild severity – 31 (26 %), moderate 47 (39 %), and severe 42 (35 %). As a result of the study, we found a association between the severity of clinical manifestations of atopic dermatitis and the level of vitamin D in the serum. Comparative analysis of the severity of atopic dermatitis, depending on the level of vitamin D in the serum, showed that with severe atopic dermatitis in children of the main group, the level of 25(OH)D was significantly lower compared to its indicators in children with moderate to severe (P < 0.05). Serum vitamin D levels are significantly lower in all forms of atopic dermatitis severity and correlate significantly with the overall SCORAD severity score, erythema intensity, excoriation, itching, and sleep disturbances. The scientific data on the presence of feedback correlation (r = –0,48; P < 0,05) between the development of atopic dermatitis in children and their level of 25(OH)D in serum were added. Our findings suggest that there is a need for a differentiated approach to treating early-stage atopic dermatitis of varying severity, a personalized therapeutic approach to choosing a vitamin D supplementation, given the level of 25(OH)D in the serum.

scholarly journals Alfacalcidol use in complex therapy of atopic dermatitis

2015 ◽  
Vol 96 (6) ◽  
pp. 952-958
Author(s):  
V Yu Pestova
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Vitamin D Deficiency ◽  
Active Form ◽  
Serum Vitamin ◽  
Clinical Results ◽  
Severe Atopic Dermatitis ◽  
Open Label ◽  
Serum Vitamin D ◽  
Complex Therapy

Aim. To study clinical course of atopic dermatitis and improve dermatosis therapeutic tactics in vitamin D deficiency. Study design - comparative observational open-label study. Methods. 67 patients with a verified «atopic dermatitis» diagnosis were selected to study. Serum calcidol level below 75 nmol/l was observed in 32 patients what was the basis to division of the observed patients into two groups. Conventional therapy (local glucocorticoids and moistening agents, systemic administration of non-specific anti-inflammatory and desensitizing agents) was administered to all patients. Vitamin D active form - alfacalcidol (Alpha D3-Teva) was administered to patients of the second group as a part of complex therapy. Results. Good clinical results have been achieved amid the treatment, in 21 days SCORAD index decreased by 86.56% in the first group, in the second - by 93.63%, with the clinical remission achievement in over 75% of patients in both groups. Atopic dermatitis complex therapy using alfacalcidol contributed to the normalization of the vitamin D concentration (from 42.92±2.87 to 79.26±4.92 nmol/l) and total calcium level (from 1.97±0.4 to 2, 21±0,8 mmol/l), reduced TEWL measurement and increased corneometry results. The therapy did not contribute to the sebometry data change in both groups. Conclusion. Vitamin D deficiency leads to more severe atopic dermatitis course; complex treatment of this disease with alfacalcidol facilitated normalization of serum vitamin D level and tendency to the epidermal barrier recovery, what opens new possibilities in the treatment of atopic dermatitis.

scholarly journals Correlation Between Serum Vitamin D Level and the Severity of Atopic Dermatitis Associated With Food Sensitization

2013 ◽  
Vol 5 (4) ◽  
pp. 207 ◽  
Author(s):  
Seon Ah Lee ◽  
Soyoung Hong ◽  
Hyun Jung Kim ◽  
Soo Hyung Lee ◽  
Hye Yung Yum
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Food Sensitization

Serum Vitamin D Levels Not Associated with Atopic Dermatitis Severity

2016 ◽  
Vol 33 (3) ◽  
pp. 283-288 ◽  
Author(s):  
Renata Robl ◽  
Marjorie Uber ◽  
Kerstin Taniguchi Abagge ◽  
Monica Nunes Lima ◽  
Vânia Oliveira Carvalho
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Atopic Dermatitis Severity ◽  
Vitamin D Levels

Nutritional status and vitamin D intake in children with severe AD

2021 ◽  
pp. 41-45
Author(s):  
S. G. Makarova ◽  
E. E. Emeliashenkov ◽  
A. P. Fisenko ◽  
N. N. Murashkin ◽  
A. A. Galimova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Nutritional Status ◽  
Negative Correlation ◽  
Serum Vitamin ◽  
Elimination Diet ◽  
Severe Atopic Dermatitis ◽  
Serum Vitamin D ◽  
Vitamin D Intake ◽  
Moderate Negative Correlation

Relevance of topic. Atopic dermatitis is a wide-spread skin disease that can significantly reduce patient’s quality of life. Many authors around the globe conduct research to find correlation between atopic detmatitis in children, their growth, development of allergic comorbidities (food allergy in particular) and elimination diet prescription.Aim of the study. To estimate growth indices and nutritional status in children with severe atopic dermatitis and allergic comorbidities on the elimination diet.Methods. This study included children of age 0-17 years 11 months, hospitalized in Dermatology with the Laser Surgery department in the National Medical Research Centre of Children’s Health from September 2020 to May 2021. Anthropometric indices, levels of serum vitamin D, albumin, hemoglobin and total IgE were estimated in all children.Results. This study included 80 children. There was a moderate negative correlation between the number of excluded food groups, the disease longitude (p = 0.003; r = -0.333) and HAZ (p = 0.010; r = -0.351). There was a moderate negative correlation between the age of children and serum vitamin D (p = 0.040; r = -0.317) and a moderate positive - between BAZ and serum vitamin D (p = 0.030; r = 0.332). There was a weak negative correlation between serum vitamin D and total serum IgE (p = 0.033; r = -0.239) and between BAZ and serum hemoglobin (p = 0.028; r = 0.246).Conclusions. The results of this study demonstrate a low intake of vitamin D in children with severe atopic dermatitis, worsening with age. Vitamin D level correlated with BAZ, also the results showed lower vitamin D intake in children with high levels of total Ig E.

scholarly journals Vitamin D Level and Supplementation in Pediatric Atopic Dermatitis: A Randomized Controlled Trial

2018 ◽  
Vol 23 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Irene Lara-Corrales ◽  
Christina M. Huang ◽  
Patricia C. Parkin ◽  
Gustavo A. Rubio-Gomez ◽  
Claudia J. Posso-De Los Rios ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Disease Severity ◽  
Controlled Trial ◽  
Phase 1 ◽  
Serum Vitamin ◽  
Skin Condition ◽  
Phase 2 ◽  
Cross Sectional ◽  
Serum Vitamin D

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a pruritic eczematous rash. Evidence surrounding the role of serum vitamin D (VD) in modifying disease severity is inconsistent. Objectives: To determine whether VD levels are correlated with AD severity and the effects of VD supplementation on disease modification. Methods: This was a 2-phase study, using a cross-sectional design to evaluate the relationship between VD level and severity, as well as a double-blinded, randomized control trial to elucidate the effects of VD supplementation. Patients aged 0 to 18 years with AD were included in phase 1, and disease severity and serum VD levels were determined. Those with renal, liver, or other dermatologic conditions were excluded. Patients with abnormal (<72.7 nmol/L) VD levels were eligible for phase 2 and to be randomized to either VD supplementation of 2000 IU/d or placebo. VD level and severity were assessed at baseline and 3 months. Results: The 77 patients included in phase 1 had a mean (SD) age of 7.4 (4.5) years, and 45.5% (33/77) were female. Increased severity was significantly correlated with lower VD levels ( P = .015). Of the 45 patients included in phase 2, 21 and 24 were assigned to the supplementation and placebo arm, respectively. The mean (SD) change in severity did not differ significantly between the supplementation (15.35 [9.71]) and placebo (15.13 [8.97]) groups after 3 months of intervention ( P = .7). Conclusion: Although VD levels correlated with AD severity, VD supplementation did not significantly improve disease severity.

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